AB703

Anti-Prion protein PrP 抗体

Anti-Prion protein PrP antibody

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(5 Publications)

Rabbit Polyclonal Prion protein PrP antibody. Suitable for WB and reacts with Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Cow PRNP.

別名を表示する

CD230, Prn-p, Prp, Prnp, Major prion protein, PrP, PrP27-30, PrP33-35C

1 Images

Unknown

Western blot - Anti-Prion protein PrP antibody (AB703)

Lane 1 : MW standard
Lane 2 : wild-type mice (PrPc)
Lane 3 : CDI/PrPsc (PK-)
Lane 4 : CDI/PrPsc (PK+),
Lane 5 : PrP 0/0 mice
CDI = clinically ill CD-1 mice, PK = digested with Proteinase K.

All lanes:

Western blot - Anti-Prion protein PrP antibody (ab703)

Predicted band size: 28 kDa

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This image is courtesy of Dr. M. Glatzel, Institut of Neuropathology, University Hospital of Zürich, Switzerland

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse

アプリケーション

applications

免疫原

Recombinant Full Length Protein corresponding to Cow PRNP.

P10279

特異性

Recognises natural PrPc and conformationally changed PrPc (PrPsc). Recognises recombinant protein ,ab753, in western blot and ELISA.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Whole antiserum

バッファー組成

Preservative: 0.02% Sodium azide Constituents: Whole serum

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Prion protein also known as PrP or major prion protein plays a mechanical role in the normal functioning of brain cells. It is a glycoprotein with a flexible structure and has an approximate mass of 35-36 kDa. PrP expression is high in nervous tissue. It is present in neurons and glial cells but also surfaces in other tissues like heart and kidney. Alternate names like p-pr-p and f89 refer to specific conformations or studies related to its structure.

Biological function summary

Prion protein assists in maintaining normal cell activities. Researchers do not fully understand its exact biological role but it might be involved in copper ion uptake and protection against oxidative stress. PrP can form complexes with other cellular proteins some of which help in routing signals inside the cell. Additionally prion protein may have synaptic functions related to neurodevelopment and neuroprotection.

Pathways

Prion protein links to both neuroprotective and neurodegenerative pathways. It participates in signaling pathways that protect neurons from apoptosis. This protein associates closely with copper-dependent pathways possibly related to its capacity to bind copper ions which affects oxidative stress responses. Prion protein also interacts with proteins like synapsin to modulate synaptic transmission.

Prion protein is directly related to prion diseases such as Creutzfeldt-Jakob disease and kuru. These diseases arise from misfolded forms of PrP which aggregate and cause neurodegeneration. The misfolded form referred to as PrP^Sc can induce normal PrP to misfold propagating disease. Dopamine receptor proteins and synaptic proteins can indirectly interact or be affected in these disorders highlighting a complex network of affected neural functions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (PubMed : 12732622, PubMed : 16492732, PubMed : 19242475, PubMed : 19568430).

See full target information Prnp

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

BMC cancer 24:1539 PubMed39695426

2024

Prion protein regulates invasiveness in glioblastoma stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mariana B Prado,Bárbara P Coelho,Rebeca P Iglesia,Rodrigo N Alves,Jacqueline M Boccacino,Camila F L Fernandes,Maria Isabel Melo-Escobar,Shamini Ayyadhury,Mario C Cruz,Tiago G Santos,Flávio H Beraldo,Jue Fan,Frederico M Ferreira,Helder I Nakaya,Marco A M Prado,Vania F Prado,Martin L Duennwald,Marilene H Lopes

Cell stress & chaperones 26:443-452 PubMed33547632

2021

Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability.

Applications

Unspecified application

Species

Unspecified reactive species

Jennifer Abrams,Taylor Arhar,Sue Ann Mok,Isabelle R Taylor,Martin Kampmann,Jason E Gestwicki

Molecular biology of the cell 26:3313-28 PubMed26224313

2015

The cellular prion protein PrPc is a partner of the Wnt pathway in intestinal epithelial cells.

Applications

Species

Unspecified reactive species

Laura S Besnier,Philippe Cardot,Barbara Da Rocha,Anthony Simon,Damarys Loew,Christophe Klein,Béatrice Riveau,Michel Lacasa,Caroline Clair,Monique Rousset,Sophie Thenet

Age (Dordrecht, Netherlands) 36:151-65 PubMed23867972

2013

Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice.

Applications

Unspecified application

Species

Unspecified reactive species

Gemma Manich,Jaume del Valle,Itsaso Cabezón,Antoni Camins,Mercè Pallàs,Carme Pelegrí,Jordi Vilaplana

PloS one 3:e3000 PubMed18714380

2008

The cellular prion protein PrP(c) is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins.

Applications

IP, IP

Species

Mouse, Human

Etienne Morel,Stéphane Fouquet,Carine Strup-Perrot,Cathy Pichol Thievend,Cathy Pichol Thievend,Constance Petit,Damarys Loew,Anne-Marie Faussat,Lucile Yvernault,Martine Pinçon-Raymond,Jean Chambaz,Monique Rousset,Sophie Thenet,Caroline Clair

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prion protein PrP 抗体

Anti-Prion protein PrP antibody

Western blot - Anti-Prion protein PrP antibody (AB703)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (5)

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