JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB233759

Anti-PRDM4/PFM1 抗体 [4B6G1]

Anti-PRDM4/PFM1 antibody [4B6G1]

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Monoclonal PRDM4/PFM1 antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PRDM4 aa 450-600.

別名を表示する

PFM1, PRDM4, PR domain zinc finger protein 4, PR domain-containing protein 4

3 Images
Flow Cytometry - Anti-PRDM4/PFM1 antibody [4B6G1] (AB233759)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-PRDM4/PFM1 antibody [4B6G1] (AB233759)

Flow cytometric analysis of HeLa (human epithelial cell line from cervix adenocarcinoma) cell line labeling PRDM4/PFM1 with ab233759 at 1/200 dilution (green) compared with a negative control (red).

Western blot - Anti-PRDM4/PFM1 antibody [4B6G1] (AB233759)
  • WB

Supplier Data

Western blot - Anti-PRDM4/PFM1 antibody [4B6G1] (AB233759)

All lanes:

Western blot - Anti-PRDM4/PFM1 antibody [4B6G1] (ab233759) at 1/500 dilution

Lane 1:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Lane 2:

PRDM4/PFM1 (AA: 476-575)-hIgGFc transfected HEK-293T whole cell lysate

Predicted band size: 88 kDa

true

Western blot - Anti-PRDM4/PFM1 antibody [4B6G1] (AB233759)
  • WB

Supplier Data

Western blot - Anti-PRDM4/PFM1 antibody [4B6G1] (AB233759)

All lanes:

Western blot - Anti-PRDM4/PFM1 antibody [4B6G1] (ab233759) at 1/500 dilution

All lanes:

Recombinant human PRDM4/PFM1 (AA: 476-575) protein

Predicted band size: 88 kDa

true

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

4B6G1

アイソタイプ

IgG1

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt, WB

applications

免疫原

Recombinant Fragment Protein within Human PRDM4 aa 450-600. The exact immunogen used to generate this antibody is proprietary information.

Q9UKN5

style
left-column

代替製品

Primary Antibodies

AB126939

Anti-PRDM4/PFM1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRDM4/PFM1 antibody (AB126939)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB315009

Anti-ATG14 antibody [EPR26188-66]

20ul selling size|RabMAb|KO Validated|Recombinant

Flow Cytometry (Intracellular) - Anti-ATG14 antibody [EPR26188-66] (AB315009)

  • 0
  • 0
Primary Antibodies

AB81887

Anti-CGRP antibody [4901]

Immunocytochemistry/ Immunofluorescence - Anti-CGRP antibody [4901] (AB81887)

  • 5
  • 9
Primary Antibodies

AB137869

Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosine Hydroxylase antibody [EP1532Y] - Neuronal Marker (AB137869)

  • 5
  • 9
Primary Antibodies

AB201457

Anti-FANCA/FAA antibody [EPR16519]

RabMAb|Recombinant|KO Validated|Trial Size

Immunoprecipitation - Anti-FANCA/FAA antibody [EPR16519] (AB201457)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
Preservative: 0.05% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PRDM4 also known as PFM1 or PFM-1 is a member of the PR domain-containing protein family. It possesses an approximate molecular weight of 75 kDa. This protein functions primarily as a transcription factor with roles in the regulation of gene expression. PRDM4 localizes mainly in the nucleus where it influences transcriptional control. Expression of PRDM4/PFM1 has been observed in various tissues but shows significant levels in the brain and reproductive organs indicating its involvement in important biological processes in these regions.
Biological function summary

PRDM4/PFM1 acts in cell differentiation and development. It is part of the KRAB-ZnF silencing complex which connects to other components to modify chromatin structure and regulate gene expression. This activity is important to maintaining cellular functions and contributes to cellular differentiation states. Understanding PRDM4/PFM1’s role within this complex can provide insights into its broader biological actions and its influence on cellular dynamics.

Pathways

PRDM4/PFM1 plays a significant role in the TGF-beta and Hedgehog signaling pathways. These pathways are major determinants of cellular growth differentiation and apoptosis. Within these pathways PRDM4/PFM1 can associate with other proteins like SMAD family members and GLI transcription factors which are important in mediating cellular responses to external signals.

PRDM4/PFM1 links to neurodegenerative conditions and certain cancers. Its dysregulation has been noted in glioblastoma where an altered expression pattern suggests its involvement in tumor progression. PRDM4/PFM1 interacts with proteins involved in these disorders such as PTEN—a known tumor suppressor gene—highlighting its potential role in the development and progression of these diseases. Understanding these connections is key for developing therapeutic strategies targeting PRDM4/PFM1-related pathways.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

May function as a transcription factor involved in cell differentiation.
See full target information PRDM4
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

BMC musculoskeletal disorders 25:1081 PubMed39736635

2024

The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sen Wang,Zhengwei Duan,Zihua Li,Dong Yang,Hengli Lu,Yiwei Zhang,Yuesong Fu,Yonghao Guan,Guodong Li,Feng Qian,Tianyang Xu
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com