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AB27269

Anti-PPP2R2C 抗体

Anti-PPP2R2C antibody

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(2 Publications)

Rabbit Polyclonal PPP2R2C antibody. Suitable for WB and reacts with Mouse, Rat, Human, Cow samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PPP2R2C aa 50-100 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, IMYPNO1, PP2A subunit B isoform B55-gamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma, PPP2R2C

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat, Cow, Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human PPP2R2C aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2T4

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代替製品

Primary Antibodies

AB172086

Anti-PPP2R2C antibody

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組合せ製品

Primary Antibodies

AB272692

Anti-MUC2 antibody [EPR23479-47]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|Trial Size

Immunohistochemistry (Frozen sections) - Anti-MUC2 antibody [EPR23479-47] (AB272692)

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Primary Antibodies

AB281583

Anti-CD31 antibody [RM1006]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [RM1006] (AB281583)

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  • 5
Primary Antibodies

AB108508

Anti-Lysozyme antibody [EPR2994(2)]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lysozyme antibody [EPR2994(2)] (AB108508)

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  • 4
Primary Antibodies

AB133263

Anti-Cytokeratin 18 antibody [EPR1626]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 18 antibody [EPR1626] (AB133263)

  • 3
  • 3
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Precipitation Ammonium Sulphate
バッファー組成
Preservative: 0.08% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Protein phosphatase 2 regulatory subunit B gamma also known as PPP2R2C or B55-gamma is a regulatory subunit of protein phosphatase 2A (PP2A). It exhibits a molecular mass of approximately 55 kDa. PPP2R2C is expressed in various tissues with higher levels found in the brain and testis. By associating with the core PP2A enzyme it modulates substrate specificity catalytic activity and subcellular localization playing a significant role in PP2A function.
Biological function summary

The protein serves as a regulatory component of the PP2A holoenzyme which consists of a structural A subunit catalytic C subunit and regulatory B subunit like PPP2R2C. This complex performs dephosphorylation functions essential for cell cycle regulation and signal transduction. By coupling with PP2A PPP2R2C influences key cellular processes such as cell growth and differentiation by modulating phosphorylation states of critical proteins.

Pathways

This regulatory subunit PPP2R2C integrates into the PI3K/AKT and MAPK signaling pathways. It serves as a modulatory bridge affecting specific protein interactions and phosphorylation events. Through these pathways PPP2R2C connects with proteins like AKT and ERK coordinating signals that regulate cell survival and proliferation while maintaining balanced phosphatase activity.

PPP2R2C associates with neurodegenerative disorders and certain cancers. Aberrations in PP2A activity regulated by PPP2R2C can lead to Alzheimer's disease where abnormal phosphorylation plays a role in tau protein aggregation. In oncology disruptions in PPP2R2C function may contribute to glioblastoma progression due to altered signaling pathways. These conditions highlight the connection of PPP2R2C with key proteins involved in disease underpinning its relevance in therapeutic research.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.
See full target information PPP2R2C
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 21:793 PubMed37940996

2023

Muc2 mucin O-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Wei,Chunyan Chen,Jing Feng,Shuping Zhou,Xiaoyue Feng,Zhao Yang,Heng Lu,Hui Tao,Liuying Li,Huabing Xv,Ji Xuan,Fangyu Wang

Investigative ophthalmology & visual science 61:10 PubMed33049058

2020

Protein Phosphatase 2A and Clathrin-Mediated Endocytosis Facilitate Robust Melanopsin Light Responses and Resensitization.

Applications

Unspecified application

Species

Unspecified reactive species

Juan C Valdez-Lopez,Meheret Gebreegziabher,Robin J Bailey,Jair Flores,Olanike Awotunde,Thomas Burnett,Phyllis R Robinson
View all publications
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Abcam product promise

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