Anti-PLGF 抗体 (ab11938)
Key features and details
- Rabbit polyclonal to PLGF
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PLGF antibody
PLGF 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PLGF -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment corresponding to Human PLGF aa 19-170.
Database link: P49763-3 -
ポジティブ･コントロール
- WB: Recombinant human PLGF
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
バッファー
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab11938の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 25 kDa.
Detects 25-50 ng/lane of recombinant human PlGF1 and PlGF2 under reducing and non-reducing conditions. |
| 特記事項 |
|---|
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WB
Use a concentration of 2 - 5 µg/ml. Predicted molecular weight: 25 kDa. Detects 25-50 ng/lane of recombinant human PlGF1 and PlGF2 under reducing and non-reducing conditions. |
ターゲット情報
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機能
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. -
組織特異性
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. -
配列類似性
Belongs to the PDGF/VEGF growth factor family. -
ドメイン
Isoform PlGF-2 contains a basic insert which acts as a cell retention signal. -
翻訳後修飾
N-glycosylated. -
細胞内局在
Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. - Information by UniProt
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参照データベース
- Entrez Gene: 5228 Human
- Omim: 601121 Human
- SwissProt: P49763 Human
- Unigene: 252820 Human
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別名
- D12S1900 antibody
- Pgf antibody
- PGFL antibody
see all
画像
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Western blot - Anti-PLGF antibody (ab11938)All lanes : Anti-PLGF antibody (ab11938)
Lane 1 : Recombinant human PLGF
Lane 2 : Recombinant mouse PLGF
Predicted band size: 25 kDaWestern analysis of human PlGF-2 with a polyclonal antibody directed against human PlGF-2 derived from insect cells.
データシートおよび資料
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Datasheet download
参考文献 (2)
ab11938 は 2 報の論文で使用されています。
- Xiaomeng F et al. Treatment with ß-elemene combined with paclitaxel inhibits growth, migration, and invasion and induces apoptosis of ovarian cancer cells by activation of STAT-NF-?B pathway. Braz J Med Biol Res 53:e8885 (2020). PubMed: 32401925
- Wang Z et al. ß-elemene enhances anticancer bone neoplasms efficacy of paclitaxel through regulation of GPR124 in bone neoplasms cells. Oncol Lett 16:2143-2150 (2018). PubMed: 30008912
