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AB15555

Anti-Placental lactogen 抗体, prediluted

Anti-Placental lactogen antibody, prediluted

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(1 Publication)

Rabbit Polyclonal CSH2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication.

別名を表示する

Chorionic somatomammotropin hormone 2, Choriomammotropin, Lactogen, Placental lactogen, PL, CSH2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental lactogen antibody, prediluted (AB15555)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental lactogen antibody, prediluted (AB15555)

ab15554 staining Human placenta by Immunohistochemistry (FFPE-sections).

This data was developed using the undiluted version of this antibody (ab15554).

Western blot - Anti-Placental lactogen antibody, prediluted (AB15555)
  • WB

Unknown

Western blot - Anti-Placental lactogen antibody, prediluted (AB15555)

This data was developed using the undiluted version of this antibody (ab15554).

Lane 1:

Western blot - Anti-Placental lactogen antibody (<a href='/products/primary-antibodies/placental-lactogen-antibody-ab15554'>ab15554</a>) at 1/25 dilution

Lane 1:

Western blot - Anti-Placental lactogen antibody, prediluted (ab15555) at 1/25 dilution

All lanes:

Human placenta lysate

Predicted band size: 25 kDa

Observed band size: 23 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/25", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1", "IHCP-species-notes": "<p>10 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at RT for 20 minutes. ab15555 shows cytoplasmic staining.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.6 Preservative: 0.1% Sodium azide Constituents: Tris buffered saline, 1% BSA
出荷温度
Blue Ice
長期保存温度
+4°C
保管に関する情報
Do Not Freeze
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Placental lactogen also known as chorionic somatomammotropin hormone is a glycoprotein hormone with a molecular mass of approximately 22 kDa. The hormone is primarily expressed in the syncytiotrophoblasts of the placenta during pregnancy. It shares structural similarities with other hormones like growth hormone and prolactin due to its polypeptide nature. Placental lactogen influences various physiological processes related to maternal and fetal development.
Biological function summary

Placental lactogen functions to modulate maternal metabolism to support fetal growth and development. It promotes changes in the maternal glucose metabolism ensuring an adequate energy supply to the fetus. This protein also stimulates mammary gland development preparing the mother for lactation. It does not form part of a larger protein complex acting independently in the biological processes it regulates.

Pathways

Researchers have found that placental lactogen plays a role in both the insulin-like growth factor (IGF) pathway and the JAK-STAT signaling pathway. It interacts with the IGF pathway to enhance nutrient uptake and fetal growth. Additionally its role in the JAK-STAT pathway ties it to immune modulation and cell proliferation. Placental lactogen is related to proteins such as the growth hormone and prolactin within these pathways due to their shared structural properties and similar mechanisms of action.

Studies have linked abnormal levels of placental lactogen to gestational diabetes mellitus and pre-eclampsia. Gestational diabetes arises when placental lactogen induces higher insulin resistance impacting maternal glucose regulation. Pre-eclampsia may involve imbalance in placental lactogen expression affecting placental vascular function. Researchers have noted interactions with proteins like leptin and insulin as these relate to glucose metabolism and vascular changes in pregnancy.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
See full target information CSH2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 24: PubMed37834175

2023

Derivation of Arbas Cashmere Goat Induced Pluripotent Stem Cells in LCDM with Trophectoderm Lineage Differentiation and Interspecies Chimeric Abilities.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Liu,Jing Wang,Yongli Yue,Chen Li,Xuemin Zhang,Jinzhu Xiang,Hanning Wang,Xueling Li
View all publications
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代替製品

Primary Antibodies

AB248818

Anti-Placental lactogen antibody [EPR8265] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental lactogen antibody [EPR8265] - BSA and Azide free (AB248818)

  • 0
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Primary Antibodies

AB137099

Anti-Placental lactogen antibody [EPR8265]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Placental lactogen antibody [EPR8265] (AB137099)

  • 0
  • 0

組合せ製品

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Secondary Antibodies

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Primary Antibodies

AB74324

Anti-Human Growth Hormone antibody

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Primary Antibodies

AB134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - Late Endosome Marker (AB134045)

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