Anti-PKD2 抗体 (ab7281)
Key features and details
- Rabbit polyclonal to PKD2
- Suitable for: ICC/IF, IHC-P, IP, WB
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-PKD2 antibody
PKD2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PKD2 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, IHC-P, IP, WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide corresponding to Human PKD2 aa 849-864.
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特記事項
This antibody recognizes human protein kinase D2 (PKD2), a serine threonine protein kinase. PKD2 is widely expressed in human and murine tissues and exhibits strong homology to the serine threonine protein kinases PKD/PKCmicro and PKCnu. In contrast, it has a low degree of sequence homology to other members of the PKC family. PKD2 is activated by phorbol esters and a variety of growth factors.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Immunogen affinity purified -
一次抗体 備考
This antibody recognizes human protein kinase D2 (PKD2), a serine threonine protein kinase. PKD2 is widely expressed in human and murine tissues and exhibits strong homology to the serine threonine protein kinases PKD/PKCmicro and PKCnu. In contrast, it has a low degree of sequence homology to other members of the PKC family. PKD2 is activated by phorbol esters and a variety of growth factors. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab7281の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
|
|
| IHC-P | (1) |
Use at an assay dependent concentration.
|
| IP |
Use at an assay dependent concentration.
|
|
| WB | (2) |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
ICC/IF
Use at an assay dependent concentration. |
|
IHC-P
Use at an assay dependent concentration. |
|
IP
Use at an assay dependent concentration. |
|
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress. -
組織特異性
Widely expressed. -
配列類似性
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Contains 1 PH domain.
Contains 2 phorbol-ester/DAG-type zinc fingers.
Contains 1 protein kinase domain. -
翻訳後修飾
Phosphorylation of Ser-876 correlates with the activation status of the kinase.
Ser-706 is probably phosphorylated by PKC. -
細胞内局在
Cytoplasm. Membrane. Translocation to the cell membrane is required for kinase activation. - Information by UniProt
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参照データベース
- Entrez Gene: 25865 Human
- Entrez Gene: 101540 Mouse
- Omim: 607074 Human
- SwissProt: Q9BZL6 Human
- SwissProt: Q8BZ03 Mouse
- Unigene: 466987 Human
- Unigene: 1881 Mouse
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別名
- DKFZp586E0820 antibody
- HSPC187 antibody
- KPCD2_HUMAN antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (4)
ab7281 は 4 報の論文で使用されています。
- Xiao Y et al. Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders. Nat Commun 9:2015 (2018). PubMed: 29789568
- Arun SN et al. Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes. Oncogene : (2010). WB ; Mouse . PubMed: 21132013
- Li J et al. PKD1, PKD2, and Their Substrate Kidins220 Regulate Neurotensin Secretion in the BON Human Endocrine Cell Line. J Biol Chem 283:2614-21 (2008). ICC/IF ; Human . PubMed: 18048355
- Jackson LN et al. Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells. Biochem Biophys Res Commun 348:945-9 (2006). PubMed: 16899224
