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AB228894

Anti-PIP5K2 gamma 抗体 - N-terminal

Anti-PIP5K2 gamma antibody - N-terminal

  • JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal PIP5K2 gamma antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PIP4K2C.

別名を表示する

PIP5K2C, PIP4K2C, Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, Phosphatidylinositol 5-phosphate 4-kinase type II gamma, PI(5)P 4-kinase type II gamma, PIP4KII-gamma

1 Images
Western blot - Anti-PIP5K2 gamma antibody - N-terminal (AB228894)
  • WB

Supplier Data

Western blot - Anti-PIP5K2 gamma antibody - N-terminal (AB228894)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-PIP5K2 gamma antibody - N-terminal (ab228894) at 1/1000 dilution

All lanes:

MCF7 (human breast adenocarcinoma cell line) whole cell lysate at 30 µg

Predicted band size: 47 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human PIP4K2C. The exact immunogen used to generate this antibody is proprietary information.

Q8TBX8

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PIP5K2 gamma also known as phosphatidylinositol-5-phosphate 4-kinase type-2 gamma is an enzyme encoded by the PIP4K2C gene. It plays an important role in cellular processes by phosphorylating phosphatidylinositol-5-phosphate to generate phosphatidylinositol-45-bisphosphate. The molecular mass of PIP5K2 gamma is approximately 51 kDa. This protein is mostly expressed in brain tissue but researchers have also found it in other tissues including the pancreas and spleen.
Biological function summary

The protein's primary role involves the regulation of phosphoinositide signaling pathways. PIP5K2 gamma participates in membrane trafficking cytoskeletal organization and signal transduction processes. It associates with different protein complexes that modulate these cellular activities. By controlling the levels of phosphatidylinositol-45-bisphosphate PIP5K2 gamma indirectly regulates several downstream signaling events.

Pathways

Scientists have shown that PIP5K2 gamma is a part of the phosphatidylinositol signaling system which is important for signal transduction and cellular communication. It interacts closely with proteins such as phospholipase C and AKT. PIP5K2 gamma also contributes to the insulin signaling pathway impacting glucose metabolism and cell proliferation.

Studies link PIP5K2 gamma to several medical conditions. Its dysregulation associates with neurological disorders including bipolar disorder. Variations in this protein are also connected to cancer. For example in cancer alterations in the PIP5K2 gamma activity may affect pathways involving the AKT protein leading to uncontrolled cell growth and survival.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed : 31091439).
See full target information PIP4K2C
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cardiovascular medicine 9:1062695 PubMed36568562

2022

Large-conductance Ca-activated K channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Meili Wang,Shuanglei Li,Hongshan Liu,Mingyuan Liu,Jin Zhang,Yang Wu,Cangsong Xiao,Haixia Huang
View all publications
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代替製品

Primary Antibodies

AB169572

Anti-PIP5K2 gamma antibody

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組合せ製品

Secondary Antibodies

AB150077

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Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Cell Lines & Lysates

AB265390

Human PIP4K2C (PIP5K2 gamma) knockout HeLa cell line

Sanger Sequencing - Human PIP4K2C (PIP5K2 gamma) knockout HeLa cell line (AB265390)

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Primary Antibodies

AB170115

Anti-PAWP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PAWP antibody (AB170115)

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Primary Antibodies

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Abcam product promise

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