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AB7851

Anti-Phosphoserine 抗体 [B106.1]

Anti-Phosphoserine antibody [B106.1]

3

(1 Review)

|

(3 Publications)

Mouse Monoclonal Phosphoserine antibody. Suitable for WB and reacts with Modified Amino Acid samples. Cited in 3 publications. Immunogen corresponding to Chemical / Small Molecule corresponding to Phosphoserine.

別名を表示する

PS, pSER, phospho-Ser

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

B106.1

アイソタイプ

IgG1

軽鎖のタイプ

unknown

キャリアフリー

No

アプリケーション

WB

applications

特異性

This antibody detects free and conjugated phosphoserine as well as phosphoserine in modified cellular proteins. It does not cross react with nonphosphorylated serine or with phosphotyrosine or phosphothreonine, neither does it cross react with AMP or ATP. However, due to steric hinderance, certain proteins known to contain phosphorylated serine may not be recognized by this antibody.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Modified Amino Acid": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/50", "WB-species-notes": "<p>Do not use milk as a blocking agent or in diluents, as milk casein is phosphorylated at several serine residues. BSA is recommended instead.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Phosphoserine often referred to by its common alternate name "P-Ser" represents a phosphorylated form of the amino acid serine. This small molecule under a molecular mass of near 166 Daltons plays an important role in cellular signaling. It is expressed widely across various cell types particularly in tissues with high cell turnover. Phosphoserine results from the action of kinases which transfer a phosphate group from ATP to the serine's hydroxyl group. This phosphorylation process provides a critical modulatory mechanism that impacts protein function and cellular pathways.
Biological function summary

Phosphorylated serine residues are involved in controlling a multitude of cellular processes including cell cycle regulation and apoptosis. These phosphorylated regions form parts of protein kinases phosphatases and glycoproteins acting as switches for cellular signaling. Phosphoserine is often part of multi-protein complexes binding to other proteins and influencing their activity through changes in conformation. This active participation in biological pathways signifies its significant influence in maintaining cellular homeostasis.

Pathways

Phosphoserine plays a significant role in the MAPK signaling and PI3K/AKT pathways both important for cell growth and survival. It interacts with proteins like AKT and MAPK facilitating cellular responses to extracellular stimuli. This phosphorylation state dictates the activation or inactivation of these proteins effectively regulating key steps in signal transduction and transcriptional control. Such pathways highlight the importance of phosphoserine in coordinating complex cellular activities.

Aberrations in phosphoserine activity have been linked to conditions such as cancer and neurodegenerative diseases. In cancer dysregulation in its phosphorylation status may lead to uncontrolled cellular proliferation and resistance to apoptosis. Proteins such as p53 which plays a pivotal role in DNA repair and cell cycle arrest often show altered phosphorylation patterns in the presence of disease. Similarly in neurodegenerative disorders improper phosphorylation of tau proteins is a hallmark of conditions like Alzheimer's disease pointing to the critical involvement of phosphoserine and its associated pathways in disease pathology.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Phosphoserine
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Pflugers Archiv : European journal of physiology 475:583-593 PubMed36917272

2023

Calcineurin-dependent regulation of gap junction conductance and connexin phosphorylation in guinea pig left atrium.

Applications

Unspecified application

Species

Unspecified reactive species

R I Jabr,S C Salvage,F S Hatch,C H Fry

Nature medicine 21:373-82 PubMed25799226

2015

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.

Applications

WB, IP

Species

Unspecified reactive species, Unspecified reactive species

Yue Wu,Ping Song,Wencheng Zhang,Junhui Liu,Xiaoyan Dai,Zhaoyu Liu,Qiulun Lu,Changhan Ouyang,Zhonglin Xie,Zhengxing Zhao,Xiaozhen Zhuo,Benoit Viollet,Marc Foretz,Jiliang Wu,Zuyi Yuan,Ming-Hui Zou

Small (Weinheim an der Bergstrasse, Germany) 6:1509-13 PubMed20578112

2010

Kinase-actuated immunoaggregation of Peptide-conjugated gold nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Shalini Gupta,Heiko Andresen,James E Ghadiali,Molly M Stevens
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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