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AB16754

Anti-Peroxiredoxin 4 抗体 [1A1]

Anti-Peroxiredoxin 4 antibody [1A1]

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Mouse Monoclonal Peroxiredoxin 4 antibody. Suitable for IP and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PRDX4.

別名を表示する

Peroxiredoxin-4, Antioxidant enzyme AOE372, Peroxiredoxin IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372, Thioredoxin-dependent peroxiredoxin 4, AOE37-2, Prx-IV, PRDX4

2 Images
Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)
  • IP

Unknown

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)

ab16754 at 1.5μg/ml immunoprecipitating Peroxiredoxin 4 from HeLa cell lysate

Lane 1 : Input

Lane 2 : Precipitates

All lanes:

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (ab16754)

Predicted band size: 31 kDa

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Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)
  • IP

Supplier Data

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (AB16754)

Ladder M.W(kDa) : 7, 17, 25, 30, 46, 58, 80, 175

All lanes:

Immunoprecipitation - Anti-Peroxiredoxin 4 antibody [1A1] (ab16754) at 1/2000 dilution

Lane 1:

HeLa Cell Lysate

Lane 2:

Precipitated from HeLa Cell Lysate 200ug using ab16754 2ug

Lane 3:

Precipitated from HeLa Cell Lysate 200ug using ab16754 5ug

Lane 4:

Precipitated from PBS using ab16754 5ug

Predicted band size: 31 kDa

false

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

1A1

アイソタイプ

IgG3

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

IP

applications

免疫原

Recombinant Fragment Protein within Human PRDX4. The exact immunogen used to generate this antibody is proprietary information.

Q13162

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1-2 µg/mL", "IP-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1-2 µg/mL", "IP-species-notes": "<p></p>" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "1-2 µg/mL", "IP-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Precipitation Ammonium Sulphate
精製に関する特記事項
Purified from TCS
バッファー組成
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Peroxiredoxin 4 also known as Prdx4 is a protein that acts as an antioxidant enzyme and belongs to the peroxiredoxin family. It influences the reduction of hydrogen peroxide and organic hydroperoxides. The molecular mass of Prdx4 is approximately 31 kDa. It is expressed mainly in the endoplasmic reticulum but you can find some expression in the cytosol as well.
Biological function summary

Prdx4 plays a list of roles in cellular defense against oxidative stress. It not only reduces peroxides but also contributes to the maintenance of protein folding by modifying disulfide bonds in the endoplasmic reticulum. Prdx4 does not function as part of a larger complex but acts independently within its compartments. The protective functions of Prdx4 are important for cell survival and proper cellular function.

Pathways

Prdx4 interacts with oxidative stress response pathways. Specifically it participates in the redox signaling pathways that regulate cellular reactive oxygen species levels. Peroxiredoxin 4 is closely associated with proteins such as thioredoxin in these pathways. Together they regulate the cellular redox environment which is important for maintaining cellular homeostasis.

Oxidative stress imbalance implicates Prdx4 in conditions like diabetes and cancer. For example in diabetes altered Prdx4 levels disturb normal cell function due to increased oxidative stress. In cancer Prdx4 can influence tumor progression by modulating the antioxidant capacity within cells. Prdx4 also shows a functional connection to proteins like glutathione peroxidase in regulating oxidative stress-related pathologies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
See full target information PRDX4
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