AB108323

Rabbit monoclonal [EPR3713] to Perilipin-2

Name: Anti-Perilipin 2 抗体 [EPR3713] (ab108323) | Abcam
Brand: Abcam Limited
SKU: AB108323
Rating: 4 (3 reviews)

Anti-Perilipin 2 antibody [EPR3713]

RabMAb
Recombinant
詳細を見る

(3 Reviews)

(41 Publications)

Anti-Perilipin 2 antibody [EPR3713] (ab108323) is a rabbit monoclonal antibody detecting Perilipin-2 in Western Blot. Suitable for Human, Mouse, Rat.

- Biophysical QC for unrivalled batch-batch consistency
- Over 40 publications

別名を表示する

ADFP, PLIN2, Perilipin-2, Adipophilin, Adipose differentiation-related protein, ADRP

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Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

Lanes 1 - 4:

Western blot - Anti-Perilipin 2 antibody [EPR3713] (ab108323) at 1/1000 dilution

Lanes 1 - 4:

Western blot - Anti-Perilipin 2 antibody [EPR3713] - BSA and Azide free (<a href='/products/primary-antibodies/perilipin-2-antibody-epr3713-bsa-and-azide-free-ab232483'>ab232483</a>) at 1/1000 dilution

Lane 1:

Human fetal liver lysate at 10 µg

Lane 2:

HepG2 lysate at 10 µg

Lane 3:

JAR lysate at 10 µg

Lane 4:

Human milk lysate at 10 µg

Predicted band size: 48 kDa

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Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

All lanes:

Western blot - Anti-Perilipin 2 antibody [EPR3713] (ab108323) at 1/1000 dilution

Lane 1:

Mouse brain lysate at 10 µg

Lane 2:

Rat brain lysate at 10 µg

Predicted band size: 48 kDa

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Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR3713

アイソタイプ

IgG

キャリアフリー

交差種

Mouse, Rat, Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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下記製品にもご興味をお持ちいただけるかもしれません:

AB185433

Lipolysis Assay Kit (Colorimetric)

1 Reviews

製品ページを見る

こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

お客様の実験に適するかご確認いただくため、必ず製品データシートをご確認いただくことをお勧めいたします。ご不明点等ございましたら、テクニカルサポートチームまでお問い合わせください。

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製品の詳細

What is this antibody validated in?
Anti-Perilipin 2 antibody [EPR3713] (ab108323) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB) in Human, Mouse, Rat samples.

What is the molecular weight of Perilipin-2?
Anti-Perilipin 2 [EPR3713] (ab108323) specifically detects a band for Perilipin-2 (UniProt: Q99541) at a molecular weight of 48kDa.

Trusted by the scientific community
Anti-Perilipin 2 [EPR3713] (ab108323) was first used in a scientific publication in 2011 and has been cited over 40 times in peer-reviewed journals.

Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies.

Other related products
We have a range of other formats of antibody clone [EPR3713] also available for your convenience: ab108323, HRP - ab201721, Carrier free - ab232483

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein Perilipin-2 also known as PLIN2 ADFP or adipophilin has an approximate molecular weight of 48 kDa. It is primarily expressed in tissues involved in lipid metabolism like adipose tissue liver and muscle. The main role of Perilipin-2 is to coat lipid droplets in cells thereby regulating lipid storage and breakdown. This protein serves as a critical component of the lipid droplet surface providing structure and protecting the lipid core from excessive unregulated lipolysis.

Biological function summary

Perilipin-2 is a member of the PAT family proteins involved in lipid droplet formation and maintenance. It does not typically form part of larger complexes but it plays a significant role in cellular energy regulation by controlling lipid reserves. This regulation ensures an efficient balance between energy storage and mobilization. The presence and levels of Perilipin-2 can influence how cells respond to nutrients particularly during periods of energy surplus or fasting.

Pathways

Perilipin-2 is heavily involved in the regulation of lipid metabolic pathways and the storage-related signaling cascades. It interacts with key metabolic proteins including hormone-sensitive lipase (HSL) to modulate lipolysis. By doing so Perilipin-2 influences processes like fatty acid mobilization and glycerol release integrating perfectly into the cellular energy balance system. The protein is also related to perilipin another member of the lipid droplet-associated proteins emphasizing its participation in lipid metabolism.

Altered expression of Perilipin-2 can have implications in obesity and fatty liver disease. The protein is involved in the accumulation of lipid droplets which is a common feature in these conditions. Obesity and associated disorders often show elevated levels of Perilipin-2 which mirrors increased lipid storage capacity. The protein's interplay with adipose tissue composition highlights its connection to obesity-related factors including other lipid droplet-associated proteins like adipose triglyceride lipase (ATGL) which influence the progression of metabolic diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets.

See full target information PLIN2

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文献 (41)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Endocrinology and metabolism 326:E842-E855 PubMed38656127

2024

Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice.

Applications

Species

Mouse

Andries Van Woerkom,Dylan J Harney,Shilpa R Nagarajan,Mariam F Hakeem-Sanni,Jinfeng Lin,Matthew Hooke,Tamara Pulpitel,Gregory J Cooney,Mark Larance,Darren N Saunders,Amanda E Brandon,Andrew J Hoy

Frontiers in immunology 14:1324205 PubMed38090559

2023

Lipid metabolism-related gene expression in the immune microenvironment predicts prognostic outcomes in renal cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhang,Bingbiao Lin,Huikun Chen,Yinyan Ye,Yijie Huang,Zhen Chen,Jun Li

Scientific reports 13:19425 PubMed37940675

2023

Low extracellular magnesium induces phenotypic and metabolic alterations in C2C12-derived myotubes.

Applications

Unspecified application

Species

Unspecified reactive species

Monica Zocchi,Marco Bartolini,Jeanette A Maier,Sara Castiglioni

Frontiers in cardiovascular medicine 10:1264901 PubMed37900572

2023

PACAP regulates VPAC1 expression, inflammatory processes and lipid homeostasis in M1- and M2-macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Roman Witzel,Annika Block,Solvey Pollmann,Leandra Oetzel,Fenja Fleck,Gabriel A Bonaterra,Ralf Kinscherf,Anja Schwarz

Heliyon 9:e20384 PubMed37780758

2023

RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Wu,Fang Wang,Carole L Moncman,Mritunjay Pandey,Harrison A Clarke,Hilaree N Frazier,Lyndsay E A Young,Matthew S Gentry,Weikang Cai,Olivier Thibault,Ramon C Sun,Douglas A Andres

iScience 26:107837 PubMed37736048

2023

Nuclear miR-150 enhances hepatic lipid accumulation by targeting RNA transcripts overlapping the promoter.

Applications

Unspecified application

Species

Unspecified reactive species

Jiao Luo,Yanan Ji,Ningning Chen,Ge Song,Shuyue Zhou,Xuan Niu,Dianke Yu

Journal of cachexia, sarcopenia and muscle 14:1454-1467 PubMed37057345

2023

Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Wanni Zhao,Yansong Zhang,Siyuan Lin,Yajuan Li,Alan Jian Zhu,Hanping Shi,Min Liu

Nature communications 14:766 PubMed36765117

2023

Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats.

Applications

Unspecified application

Species

Unspecified reactive species

Noble Kumar Talari,Ushodaya Mattam,Niroj Kumar Meher,Arun Kumar Paripati,Kalyankar Mahadev,Thanuja Krishnamoorthy,Naresh Babu V Sepuri

Cell reports 42:112091 PubMed36763501

2023

PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Miwa Hara,Wenjing Wu,Volha V Malechka,Yusuke Takahashi,Jian-Xing Ma,Gennadiy Moiseyev

Human molecular genetics 32:1466-1482 PubMed36519761

2022

Parkin regulates neuronal lipid homeostasis through SREBP2-lipoprotein lipase pathway-implications for Parkinson's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Willcyn Tang,John Thundyil,Grace Gui Yin Lim,Teddy J W Tng,Sean Qing Zhang Yeow,Aditya Nair,Chou Chai,Tso-Pang Yao,Kah-Leong Lim

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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Rabbit monoclonal [EPR3713] to Perilipin-2

Anti-Perilipin 2 antibody [EPR3713]

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

関連する標識済み抗体及び組成の異なる製品 (2)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

下記製品にもご興味をお持ちいただけるかもしれません:

Lipolysis Assay Kit (Colorimetric)

こちらの製品も推奨する理由

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (41)

Abcam product promise

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