AB234281

PerCP Anti-Syndecan-1 抗体 [MI15]

Name: PerCP Anti-Syndecan-1 抗体 [MI15] (ab234281) | Abcam
Brand: Abcam Limited
SKU: AB234281
Price: 46000 JPY
Availability: InStock

PerCP Anti-Syndecan-1 antibody [MI15]

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(1 Publication)

Mouse Monoclonal Syndecan-1 antibody - conjugated to PerCP. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing SDC1 protein.

別名を表示する

CD138, SDC, SDC1, Syndecan-1, SYND1

1 Images

Flow Cytometry - PerCP Anti-Syndecan-1 antibody [MI15] (AB234281)

Flow Cyt

Supplier Data

Flow Cytometry - PerCP Anti-Syndecan-1 antibody [MI15] (AB234281)

Surface staining of human peripheral blood for Syndecan-1 using ab234281 at 10 μl/10⁶ cells. Leukocyte + monocyte gate.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

MI15

アイソタイプ

IgG1

標識

PerCP

励起波長/蛍光波長

Ex: 490nm, Em: 675nm

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing SDC1 protein. The exact immunogen used to generate this antibody is proprietary information.

P18827

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" }, "Primates": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Size-exclusion chromatography

精製に関する特記事項

The purified antibody is conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

バッファー組成

pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

Do Not Freeze|Store in the dark

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Syndecan-1 also known as CD138 is a transmembrane heparan sulfate proteoglycan with a molecular weight of approximately 30 to 80 kDa. The size variation arises from differences in its glycosaminoglycan chains. This protein resides predominantly on the surface of epithelial cells and plasma cells. Researchers commonly use the CD138 marker to identify these cells in biological samples. It plays a significant role in cell-cell and cell-matrix interactions acting as a co-receptor for a variety of growth factors cytokines and extracellular matrix proteins.

Biological function summary

Syndecan-1 participates in tissue repair inflammation and cell signaling ensuring epithelial integrity and communication. Syndecan-1 influences cell behavior by interacting with other components of the extracellular matrix and different membrane receptors. It is also involved in forming and regulating proteoglycan complexes at the cell surface. These complex interactions facilitate the modulation of cell proliferation migration and differentiation which are fundamental to maintaining tissue architecture and function.

Pathways

Syndecan-1 actively contributes to both the Wnt and FGF signaling pathways. Through its interaction with proteins such as miR-15 syndecan-1 modulates cellular responses essential for developmental processes and tissue homeostasis. The connection with these pathways allows syndecan-1 to integrate and relay extracellular signals impacting gene expression and cellular behavior. Its relationship with other proteins like A38 as a co-receptor emphasizes its role in finely tuning signaling cascades within cellular environments.

Syndecan-1 shows a connection to multiple myeloma and breast cancer. The overexpression of syndecan-1 in these conditions disrupts normal cellular functions and promotes tumorigenesis by aiding in the tumor cell's adhesion migration and invasion. Its interaction with proteins such as perCP further demonstrates its role in disease progression providing potential as a therapeutic target. These relationships make syndecan-1 an important focus for research in oncology and other fields of disease study.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

The protein expressed by the SDC1 gene is a cell surface proteoglycan with heparan sulfate and chondroitin sulfate, linking the cytoskeleton to the interstitial matrix. It regulates exosome biogenesis alongside SDCBP and PDCD6IP. This supplementary information is collated from multiple sources and compiled automatically.

See full target information SDC1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e36483 PubMed39253182

2024

Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates.

Applications

Unspecified application

Species

Unspecified reactive species

Edward F Greenberg,Martin J Voorbach,Alexandra Smith,David R Reuter,Yuchuan Zhuang,Ji-Quan Wang,Dustin W Wooten,Elizabeth Asque,Min Hu,Carolin Hoft,Ryan Duggan,Matthew Townsend,Karin Orsi,Karen Dalecki,Willi Amberg,Lori Duggan,Heather Knight,Joseph S Spina,Yupeng He,Kennan Marsh,Vivian Zhao,Suzanne Ybarra,Jennifer Mollon,Yuni Fang,Aparna Vasanthakumar,Susan Westmoreland,Mathias Droescher,Sjoerd J Finnema,Hana Florian

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PerCP Anti-Syndecan-1 抗体 [MI15]

PerCP Anti-Syndecan-1 antibody [MI15]

Flow Cytometry - PerCP Anti-Syndecan-1 antibody [MI15] (AB234281)

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Key facts

宿主種

クローン性

クローン番号

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

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Abcam product promise