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AB323730

PE Anti-LY75/DEC-205 抗体 [EPR27222-93]

PE Anti-LY75/DEC-205 antibody [EPR27222-93]

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Rabbit Recombinant Monoclonal LY75 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples.

別名を表示する

CD205, Cd205, SMU_610, spaP, Lymphocyte antigen 75, Ly-75, DEC-205

1 Images
Flow Cytometry - PE Anti-LY75/DEC-205 antibody [EPR27222-93] (AB323730)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-LY75/DEC-205 antibody [EPR27222-93] (AB323730)

Flow cytometric analysis of Mouse splenocyte cells labelling LY75/DEC-205 with ab323730 at 1/50 dilution (1ug) (Red) and Blue compared with a isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody).

Cells were stained with CD11c conjugated to Brilliant Violet 421 and CD8a conjugated to Alexa Fluor® 647. Gated on viable CD11c+ CD8a neg and CD11c+ CD8a+ populations.

関連する標識済み抗体及び組成の異なる製品 (3)

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-LY75/DEC-205 antibody [EPR27222-93]

  • Unconjugated

    Anti-LY75/DEC-205 antibody [EPR27222-93]

  • Carrier free

    Anti-LY75/DEC-205 antibody [EPR27222-93] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR27222-93

アイソタイプ

IgG

標識

PE

励起波長/蛍光波長

Ex: 480;565nm, Em: 578nm

キャリアフリー

No

交差種

Mouse, Human, Mouse

アプリケーション

Flow Cyt

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

Not suitable for FC-human.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/50", "FlowCyt-species-notes": "<p></p>" } } }
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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
+4°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein LY75 also known as DEC-205 is a type I transmembrane glycoprotein belonging to the C-type lectin receptor family. It has a molecular mass of approximately 205 kDa. LY75 is expressed mainly on dendritic cells macrophages and B lymphocytes playing a critical role in antigen uptake and processing. The receptor exhibits high-affinity binding to carbohydrate structures facilitating its function in the immune response.
Biological function summary

LY75/DEC-205 functions primarily in the immune system by mediating endocytosis of antigens for processing and presentation to T cells. It operates either alone or as part of a larger protein complex guiding immune surveillance and response. In particular it influences the maturation and activation of dendritic cells critical processes for initiating adaptive immunity.

Pathways

LY75/DEC-205 is integral to the antigen processing and presentation pathway interacting significantly with proteins like the major histocompatibility complex (MHC) molecules. The receptor also engages in the Toll-like receptor signaling pathway linking innate and adaptive immunity through its collaborations with these receptor proteins.

LY75/DEC-205 associates with autoimmune diseases and certain cancers. Its expression and function in dendritic cells implicate it in autoimmune conditions such as lupus where immune regulation is disrupted. It may also relate to tumor progression in cancers with an immune evasion component like melanoma. This connection involves proteins like PD-L1 which tumor cells express to escape immune recognition.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity).
See full target information Ly75
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Abcam product promise

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