AB24884

PE Anti-Ly6g 抗体 [RB6-8C5]

PE Anti-Ly6g antibody [RB6-8C5]

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(11 Publications)

Rat Monoclonal Ly6g antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 11 publications.

別名を表示する

Lymphocyte antigen 6G, Ly-6G, Ly-6G.1, Ly6g

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

RB6-8C5

アイソタイプ

IgG2b

軽鎖のタイプ

kappa

標識

励起波長/蛍光波長

Ex: 480;565nm, Em: 578nm

キャリアフリー

交差種

Mouse

アプリケーション

Flow Cyt

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製度

IgG fraction

精製に関する特記事項

Purified from TCS

バッファー組成

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 0.87% Sodium chloride, 0.142% Sodium dihydrogen phosphate, 0.1% Gelatin

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Do Not Freeze

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Ly6G also known as lymphocyte antigen 6 complex locus G6D 1A8 or 8C5 is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. The molecule has a molecular weight of about 25-30 kDa. Its expression is mainly on neutrophils and a subpopulation of eosinophils in mice. It plays a role in the innate immune system marking these immune cells for differentiation and response to infection. Researchers consider it a specific marker for detecting and isolating mouse neutrophils often using methods such as Ly6G staining or anti-Ly6G antibodies for identification.

Biological function summary

Ly6G functions in the immune response by facilitating the migration and adhesion of neutrophils to the site of infection or injury. It is part of a protein complex on the cell surface that includes other Ly6 proteins. This group of proteins helps to modulate signal transduction for immune cell functions. Ly6G serves as an anchor through its GPI linkage aiding cell-to-cell communication and signal amplification in inflammation processes.

Pathways

Ly6G is significantly integrated into the immune signaling pathways notably the toll-like receptor (TLR) signaling pathway. Through these pathways Ly6G influences neutrophil migration and activation. Closely associated proteins include CD11b and CD18 which interact with Ly6G in neutrophil functions including adhesion and transmigration. These pathways are essential for orchestrating the body's defense mechanisms against pathogens.

Ly6G plays an essential role in inflammatory conditions and autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Aberrant expression or function of Ly6G can alter neutrophil behavior which contributes to disease pathology. Researchers are investigating the relationship between Ly6G and other immune-related proteins like myeloperoxidase (MPO) and elastase as these protein interactions may impact the development and progression of inflammatory diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information Ly6g

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文献 (11)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunological methods 197:139-50 PubMed8890901

1996

Flow cytometric identification of murine neutrophils and monocytes.

Applications

Unspecified application

Species

Unspecified reactive species

E Lagasse,I L Weissman

Journal of virology 70:898-904 PubMed8551629

1996

Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea.

Applications

Unspecified application

Species

Unspecified reactive species

T M Tumpey,S H Chen,J E Oakes,R N Lausch

Journal of leukocyte biology 57:827-31 PubMed7790763

1995

Neutrophils are essential for resolution of primary and secondary infection with Listeria monocytogenes.

Applications

Unspecified application

Species

Unspecified reactive species

A L Rakhmilevich

Journal of immunology (Baltimore, Md. : 1950) 152:1836-46 PubMed8120393

1994

Administration of anti-granulocyte mAb RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection.

Applications

Unspecified application

Species

Unspecified reactive species

C J Czuprynski,J F Brown,N Maroushek,R D Wagner,H Steinberg

The Journal of experimental medicine 179:259-68 PubMed8270870

1994

Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody.

Applications

Unspecified application

Species

Unspecified reactive species

J W Conlan,R J North

Journal of immunology (Baltimore, Md. : 1950) 151:2399-408 PubMed8360469

1993

Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.

Applications

Unspecified application

Species

Unspecified reactive species

T J Fleming,M L Fleming,T R Malek

The Journal of experimental medicine 178:151-61 PubMed7686211

1993

Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.

Applications

Unspecified application

Species

Unspecified reactive species

A Stoppacciaro,C Melani,M Parenza,A Mastracchio,C Bassi,C Baroni,G Parmiani,M P Colombo

Journal of immunology (Baltimore, Md. : 1950) 147:22-8 PubMed1711076

1991

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

Applications

Unspecified application

Species

Unspecified reactive species

K Hestdal,F W Ruscetti,J N Ihle,S E Jacobsen,C M Dubois,W C Kopp,D L Longo,J R Keller

European journal of immunology 18:1819-26 PubMed2849552

1988

Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma.

Applications

Unspecified application

Species

Unspecified reactive species

M A Jutila,F G Kroese,K L Jutila,A M Stall,S Fiering,L A Herzenberg,E L Berg,E C Butcher

Journal of immunology (Baltimore, Md. : 1950) 138:4313-21 PubMed3584977

1987

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes.

Applications

Unspecified application

Species

Unspecified reactive species

D M Lewinsohn,R F Bargatze,E C Butcher

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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PE Anti-Ly6g 抗体 [RB6-8C5]

PE Anti-Ly6g antibody [RB6-8C5]

関連する標識済み抗体及び組成の異なる製品 (6)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

Reactivity data

出荷温度及び保存条件

製品の状態

精製度

精製に関する特記事項

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (11)

Abcam product promise

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