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PE Anti-Integrin alpha 6 抗体 [450-30A] (ab30497)

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Flow Cytometry - PE Anti-Integrin alpha 6 antibody [450-30A] (ab30497)

    Key features and details

    • PE Mouse monoclonal [450-30A] to Integrin alpha 6
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Conjugation: PE. Ex: 488nm, Em: 575nm
    • Isotype: IgG1

    製品の概要

    • 製品名

      PE Anti-Integrin alpha 6 antibody [450-30A]
      Integrin alpha 6 一次抗体 製品一覧

    • 製品の詳細

      PE Mouse monoclonal [450-30A] to Integrin alpha 6

    • 由来種

      Mouse

    • 標識

      PE. Ex: 488nm, Em: 575nm

    • アプリケーション

      適用あり: Flow Cytmore details

    • 種交差性

      交差種: Human

    • 免疫原

      Full length native protein (Human): Alpha 6 beta 4 integrin purified from A431 cells

    • ポジティブ･コントロール

      • human peripheral blood monocytes.

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab30497の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    Flow Cyt
    Use 10µl for 106 cells.

    ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. 
    特記事項
    Flow Cyt
    Use 10µl for 106 cells.

    ab91357 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. 

    ターゲット情報

    • 機能

      Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).

    • 組織特異性

      Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney).

    • 関連疾患

      Epidermolysis bullosa letalis, with pyloric atresia

    • 配列類似性

      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.

    • 翻訳後修飾

      Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
      In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner enhancing cell invasion and migration in vitro.
      Palmitoylation by DHHC3 enhances stability and cell surface expression.

    • 細胞内局在

      Cell membrane. Cell membrane.
    • Information by UniProt

    • 参照データベース

      • 別名

        • Alpha6p antibody
        • CD49 antigen-like family member F antibody
        • CD49f antibody
        • Integrin alpha6B antibody
        • Integrin, alpha 6 antibody
        • ITA6_HUMAN antibody
        • ITGA6 antibody
        • ITGA6B antibody
        • Processed integrin alpha-6 antibody
        • VLA 6 antibody
        • VLA-6 antibody
        see all

      画像

      • Flow Cytometry - PE Anti-Integrin alpha 6 antibody [450-30A] (ab30497)
        Flow Cytometry - PE Anti-Integrin alpha 6 antibody [450-30A] (ab30497)
        Flow cytometric analysis of peripheral blood monocytes with 10µl for 106 cells of anti human Integrin alpha 6 Phycoerythrin conjugated (ab30497).

      参考文献 (3)

      ab30497 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab30497 は 3 報の論文で使用されています。

      • Djidrovski I  et al. SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells. Stem Cells 39:1310-1321 (2021). PubMed: 34152044
      • Zhou H  et al. Feasibility of repairing full-thickness skin defects by iPSC-derived epithelial stem cells seeded on a human acellular amniotic membrane. Stem Cell Res Ther 10:155 (2019). PubMed: 31151466
      • Warstat K  et al. Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis. Ann Rheum Dis 69:270-5 (2010). PubMed: 19279017

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