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AB205541

PE Anti-Estrogen Receptor beta 抗体 [ERb455]

PE Anti-Estrogen Receptor beta antibody [ERb455]

0

(1 Review)

|

(2 Publications)

Mouse Monoclonal ESR2 antibody - conjugated to PE. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ESR2.

別名を表示する

ESTRB, NR3A2, ESR2, Estrogen receptor beta, ER-beta, Nuclear receptor subfamily 3 group A member 2

1 Images
Flow Cytometry - PE Anti-Estrogen Receptor beta antibody [ERb455] (AB205541)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE Anti-Estrogen Receptor beta antibody [ERb455] (AB205541)

Flow cytometry analysis of MCF-7 cells labeling Estrogen Receptor beta using ab205541 at 5 μL for 106 cells (Red). Black : Cells alone; Green : Isotype control.

関連する標識済み抗体及び組成の異なる製品 (1)

  • Unconjugated

    Anti-Estrogen Receptor beta 1 antibody [ERb455] - C-terminal

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

ERb455

アイソタイプ

IgG2a

標識

PE

励起波長/蛍光波長

Ex: 480;565nm, Em: 578nm

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Recombinant Fragment Protein within Human ESR2. The exact immunogen used to generate this antibody is proprietary information.

Q92731

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>or 5 μL per 100 μL of whole blood</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
精製に関する特記事項
Purified from Bioreactor concentrate.
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.
Biological function summary

Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.

Pathways

Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.

Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed : 20074560).. Isoform 2. Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
See full target information ESR2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:112649 PubMed40502701

2025

Central role of regular firing neurons of centrolateral amygdala in affective behaviors.

Applications

Unspecified application

Species

Unspecified reactive species

Alvaro García,M Isabel Aller,Ana V Paternain,Juan Lerma

Cells 11: PubMed35011679

2021

MFUM-BrTNBC-1, a Newly Established Patient-Derived Triple-Negative Breast Cancer Cell Line: Molecular Characterisation, Genetic Stability, and Comprehensive Comparison with Commercial Breast Cancer Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Kristijan Skok,Lidija Gradišnik,Helena Čelešnik,Marko Milojević,Uroš Potočnik,Gregor Jezernik,Mario Gorenjak,Monika Sobočan,Iztok Takač,Rajko Kavalar,Uroš Maver
View all publications
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代替製品

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Primary Antibodies

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組合せ製品

Assay Kits

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Primary Antibodies

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Primary Antibodies

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Secondary Antibodies

AB150077

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Primary Antibodies

AB194195

Alexa Fluor® 647 Anti-Androgen Receptor antibody [EPR1535(2)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-Androgen Receptor antibody [EPR1535(2)] (AB194195)

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Abcam product promise

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