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AB233653

PE/Cy7® Anti-CD163 抗体 [GHI61]

PE/Cy7® Anti-CD163 antibody [GHI61]

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(2 Publications)

Anti-CD163 antibody [GHI61] conjugated to PE/Cy7® - suitable for flow cytometry, and reacts with human samples. Clone [GHI61] is a mouse monoclonal antibody.

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別名を表示する

CD163, M130, Scavenger receptor cysteine-rich type 1 protein M130, Hemoglobin scavenger receptor

1 Images
Flow Cytometry - PE/Cy7® Anti-CD163 antibody [GHI61] (AB233653)
  • Flow Cyt

Supplier Data

Flow Cytometry - PE/Cy7® Anti-CD163 antibody [GHI61] (AB233653)

Surface staining of human peripheral blood using ab233653.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

GHI61

アイソタイプ

IgG1

標識

PE/Cy7®

励起波長/蛍光波長

Ex: 565nm, Em: 778nm

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing CD163 protein. The exact immunogen used to generate this antibody is proprietary information.

Q86VB7

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代替製品

Primary Antibodies

AB182422

Anti-CD163 antibody [EPR19518]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Anti-CD163 antibody [EPR19518] (AB182422)

  • 5
  • 17
Primary Antibodies

AB199427

Anti-CD163 antibody [EPR14336]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD163 antibody [EPR14336] (AB199427)

  • 0
  • 0
Primary Antibodies

AB218294

Alexa Fluor® 647 Anti-CD163 antibody [EPR14643-36] - C-terminal

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD163 antibody [EPR14643-36] - C-terminal (AB218294)

  • 4
  • 1
Primary Antibodies

AB215976

Anti-CD163 antibody [EPR14643-36] - Low endotoxin, Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD163 antibody [EPR14643-36] - Low endotoxin, Azide free (AB215976)

  • 1
  • 1
Primary Antibodies

AB213612

Anti-CD163 antibody [EPR19518] - BSA and Azide free

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-CD163 antibody [EPR19518] - BSA and Azide free (AB213612)

  • 0
  • 0
Primary Antibodies

AB189915

Anti-CD163 antibody [EPR14643-36] - C-terminal

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD163 antibody [EPR14643-36] - C-terminal (AB189915)

  • 4
  • 3

組合せ製品

Assay Kits

AB274394

Human CD163 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CD163 ELISA Kit (AB274394)

  • 0
  • 0
Primary Antibodies

AB270647

FITC Anti-CD206 antibody [15-2]

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

  • 0
  • 0
Primary Antibodies

AB302698

Alexa Fluor® 647 Anti-CD14 antibody [SP192]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD14 antibody [SP192] (AB302698)

  • 0
  • 0
Primary Antibodies

AB288358

Alexa Fluor® 647 Anti-CD86 antibody [EPR21962]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-CD86 antibody [EPR21962] (AB288358)

  • 0
  • 0
Primary Antibodies

AB200315

Alexa Fluor® 488 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-CD45 antibody [EP322Y] (AB200315)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Size-exclusion chromatography
バッファー組成
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD163 known also as hemoglobin scavenger receptor is a membrane glycoprotein with a molecular weight of approximately 130 kDa. It is predominantly expressed by monocytes and macrophages which are types of immune cells. Located on the cell surface CD163 functions as a receptor that aids in the clearance of hemoglobin-haptoglobin complexes playing a critical role in maintaining iron homeostasis and protecting tissues from oxidative damage. CD163 is not limited to human cells only; researchers often study its function using animal models such as chimeric rodents and chimeric rats.
Biological function summary

CD163 participates in anti-inflammatory processes and is linked to immune modulation. It plays a pivotal role in the resolution of inflammation and promotes the removal of damaged cells and tissues. Through its involvement in the endocytic pathway CD163 interacts with various ligands facilitating interactions with other proteins. In the context of research CD163 functionality can be analyzed using techniques like CD163 IHC CD163 ELISA and CD163 stain in both human and mouse models.

Pathways

CD163 is integral to the inflammation and immune response pathways. It participates in the heme-oxygenase pathway which is essential in the breakdown of heme into biliverdin free iron and carbon monoxide. This pathway involvement is tightly linked with heme oxygenase-1 (HO-1) a cytoprotective enzyme that helps to mitigate inflammatory responses. The interaction with haptoglobin and related proteins provides further insight into its regulatory roles within the immune system.

CD163 is associated with conditions like atherosclerosis and acute inflammation disorders. Its elevated levels indicate macrophage activation observed in chronic inflammations such as cardiovascular diseases. In atherosclerosis CD163 expression correlates with the uptake of oxidized LDL connecting it to progression of the disease. Additionally soluble CD163 levels serve as a biomarker in conditions like chronic liver disease where it is linked to macrophage activation and fibrosis. Within these disorders proteins like LDL and inflammatory cytokines are closely associated with CD163 function and regulation.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
See full target information CD163
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Bioactive materials 43:255-272 PubMed39386219

2024

Self-assembled PROTACs enable protein degradation to reprogram the tumor microenvironment for synergistically enhanced colorectal cancer immunotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Xinchen Lu,Jinmei Jin,Ye Wu,Jiayi Lin,Xiaokun Zhang,Shengxin Lu,Jiyuan Zhang,Chunling Zhang,Maomao Ren,Hongzhuan Chen,Weidong Zhang,Xin Luan

World journal of clinical cases 9:2181-2191 PubMed33869594

2021

Iguratimod promotes transformation of mononuclear macrophages in elderly patients with rheumatoid arthritis by nuclear factor-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sha Liu,Li-Ping Song,Rong-Bin Li,Le-Heng Feng,Hui Zhu
View all publications
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Abcam product promise

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