AB25272

PE/Cy5® Anti-CD90 / Thy1 抗体 [G7]

Name: PE/Cy5® Anti-CD90 / Thy1 抗体 [G7] (ab25272) | Abcam
Brand: Abcam Limited
SKU: AB25272
Rating: 5 (1 reviews)

PE/Cy5® Anti-CD90 / Thy1 antibody [G7]

(1 Review)

(8 Publications)

Rat Monoclonal CD90 / Thy1 antibody - conjugated to PE/Cy5®. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 8 publications.

別名を表示する

CD90, Thy-1 membrane glycoprotein, CDw90, Thy-1 antigen, THY1

1 Images

Flow Cytometry - PE/Cy5® Anti-CD90 / Thy1 antibody [G7] (AB25272)

Flow Cyt

Unknown

Flow Cytometry - PE/Cy5® Anti-CD90 / Thy1 antibody [G7] (AB25272)

Flow Cytometry analysis of C57BL/6 mouse splenocytes stained with Anti-CD90 / Thy1 antibody [G7] (PE/Cy5) ab25272 (1 μg/10⁶cells) and Rat Anti-Mouse CD3-epsilon-PE.

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

アイソタイプ

IgG2c

軽鎖のタイプ

kappa

標識

PE/Cy5®

励起波長/蛍光波長

Ex: 496nm, Em: 667nm

キャリアフリー

交差種

Mouse

アプリケーション

Flow Cyt

applications

特異性

ab25272 is specific for Thy-1.1 and Thy-1.2 alloantigens (Thy-1 epitope region A).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.2 µg for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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製品の詳細

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification

バッファー組成

pH: 7.1 Preservative: 0.09% Sodium azide Constituents: PBS, 16% Sucrose, 0.2% Gelatin

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

Store in the dark

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD90 also known as Thy1 is a glycoprotein with a molecular mass of approximately 25-37 kDa. It is highly conserved across species and found on the surface of various cell types including fibroblasts neurons and endothelial cells. CD90 is expressed in these cells in tissues such as the brain thymus and lungs. Researchers use anti-CD90 antibodies for detection often in combination with CD90 FITC in immunofluorescence assays. CD90 serves as a useful cell marker particularly in identifying mesenchymal stem cells (MSCs).

Biological function summary

CD90 plays a role in cell-cell and cell-matrix interactions contributing to cellular adhesion migration and signal transduction. It functions as part of a complex involving integrins which mediate its interaction with the extracellular matrix. This protein also influences T-cell activation reflecting its importance in immune response regulation. Its presence aids in modulating response to injury and promoting tissue repair due to its association with stem and progenitor cells.

Pathways

CD90 engagement affects focal adhesion and MAPK signaling pathways. It interacts with integrins like αvβ3 and α5β1 influencing cell movement and proliferation processes. CD90 involvement in these pathways allows it to regulate responses important for cell survival and communication within various tissues. These interactions highlight the protein's role in maintaining cellular homeostasis and regulating physiological processes.

CD90 has associations with fibrosis and cancer. In fibrotic conditions CD90 expression affects fibroblast activity influencing tissue scarring in organs such as the liver and lungs. In cancer CD90 modifies tumor progression and metastasis by impacting cell adhesion and migration with connections to proteins like TGF-beta which further drive these processes. Understanding CD90 in disease contexts facilitates the development of therapeutic strategies aimed at modulating its activity.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

See full target information THY1

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文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Experimental physiology 105:876-885 PubMed32052500

2020

microRNA-143-3p regulates odontogenic differentiation of human dental pulp stem cells through regulation of the osteoprotegerin-RANK ligand pathway by targeting RANK.

Applications

Unspecified application

Species

Unspecified reactive species

Changwei Yang,Ru Jia,Qiliang Zuo,Yanfen Zheng,Qianju Wu,Bizhu Luo,Pingting Lin,Lu Yin

Molecular medicine reports 19:813-820 PubMed30569163

2018

Effects of menstrual blood‑derived stem cells on endometrial injury repair.

Applications

Unspecified application

Species

Unspecified reactive species

Jia Hu,Kuangyu Song,Jing Zhang,Yiqiong Zhang,Bu-Zhen Tan

The Journal of experimental medicine 179:785-96 PubMed7906706

1994

Thy-1 triggers mouse thymocyte apoptosis through a bcl-2-resistant mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

A O Hueber,G Raposo,M Pierres,H T He

Journal of immunology (Baltimore, Md. : 1950) 149:1583-92 PubMed1380534

1992

Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.

Applications

Unspecified application

Species

Unspecified reactive species

D S Ucker,J Meyers,P S Obermiller

The Journal of experimental medicine 173:515-8 PubMed1671083

1991

Thy-1 supports adhesion of mouse thymocytes to thymic epithelial cells through a Ca2(+)-independent mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

H T He,P Naquet,D Caillol,M Pierres

Cellular immunology 130:271-80 PubMed1976441

1990

Selection of T cell receptor expression mutants through the functionally linked Ly-6A.

Applications

Unspecified application

Species

Unspecified reactive species

E Sugiyama,A Cantagrel,T Reno,F Stafford-Brady,E T Yeh,J V Bonventre

Journal of immunology (Baltimore, Md. : 1950) 140:1089-94 PubMed2893823

1988

Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

Applications

Unspecified application

Species

Unspecified reactive species

L Tentori,D M Pardoll,J C Zuñiga,J Hu-Li,W E Paul,J A Bluestone,A M Kruisbeek

The Journal of experimental medicine 159:716-30 PubMed6142077

1984

T cell-activating properties of an anti-Thy-1 monoclonal antibody. Possible analogy to OKT3/Leu-4.

Applications

Unspecified application

Species

Unspecified reactive species

K C Gunter,T R Malek,E M Shevach

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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PE/Cy5® Anti-CD90 / Thy1 抗体 [G7]

PE/Cy5® Anti-CD90 / Thy1 antibody [G7]

Flow Cytometry - PE/Cy5® Anti-CD90 / Thy1 antibody [G7] (AB25272)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

特異性

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (8)

Abcam product promise

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