AB319372

PE Anti-Claudin18.2 + Claudin18.1 抗体 [EPR19203]

PE Anti-Claudin18.2 + Claudin18.1 antibody [EPR19203]

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal Claudin 18 antibody - conjugated to PE.

別名を表示する

UNQ778/PRO1572, CLDN18, Claudin-18

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR19203

アイソタイプ

IgG

標識

励起波長/蛍光波長

Ex: 480;565nm, Em: 578nm

キャリアフリー

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle|Store in the dark

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Claudin18.2 and Claudin18.1 are integral membrane proteins part of the claudin family which are tight junction proteins. Claudin18.2 has a molecular weight of approximately 27 kDa. These proteins are primarily expressed in epithelial cells particularly within the gastric mucosa and lung tissue. They serve as essential components of cell-cell adhesion influencing paracellular transport and maintaining cell polarity.

Biological function summary

These proteins are vital in forming tight junction strands contributing to cellular barrier functions. Claudin18.2 and Claudin18.1 belong to a multi-protein complex vital for establishing cell permeability limits. Through their integration in tight junctions they regulate ion passage minimize fluid loss and maintain tissue homeostasis. Their dynamic nature allows adaptation in response to physiological stimuli making them central to epithelial barrier integrity.

Pathways

Claudins including Claudin18.2 and Claudin18.1 play roles in signaling pathways like Wnt and MAPK which are pivotal for cellular processes like proliferation and differentiation. These pathways involve interactions with proteins like ZO-1 and occludin contributing to the signaling processes across the epithelial cells. This involvement with important signaling proteins highlights their importance in maintaining cell function and signaling responses.

These claudins have strong associations with gastric cancer and asthma pathophysiology. Overexpression of Claudin18.2 has been shown in gastric cancer indicating its potential as a therapeutic target. In asthma altered expression of Claudin18.1 affects lung epithelial integrity linking these proteins to airway inflammation and remodeling. The connection with proteins like E-cadherin and beta-catenin further highlights their role in tumor progression and epithelial transformation making them relevant in clinical research.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

The protein expressed by the gene CLDN18 plays a major role in the tight junction-specific obliteration of the intercellular space through calcium-independent cell-adhesion activity. This supplementary information is collated from multiple sources and compiled automatically.

See full target information CLDN18

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-Claudin18.2 + Claudin18.1 抗体 [EPR19203]

PE Anti-Claudin18.2 + Claudin18.1 antibody [EPR19203]

関連する標識済み抗体及び組成の異なる製品 (8)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

アプリケーション

免疫原

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

組合せ製品

Proteins & Peptides

Proteins & Peptides

Primary Antibodies

Primary Antibodies

Abcam product promise