AB93567

PE Anti-CD105 抗体 [MJ7/18]

Name: PE Anti-CD105 抗体 [MJ7/18] (ab93567) | Abcam
Brand: Abcam Limited
SKU: AB93567
Price: 35000 JPY
Availability: InStock

PE Anti-CD105 antibody [MJ7/18]

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(8 Publications)

Anti-CD105 antibody [MJ7/18] conjugated to PE - suitable for flow cytometry, and reacts with mouse samples. Clone [MJ7/18] is a rat monoclonal antibody and one of the most commonly used clones for flow cytometry.

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別名を表示する

CD105, Edg, Eng, Endoglin, Cell surface MJ7/18 antigen

1 Images

Flow Cytometry - PE Anti-CD105 antibody [MJ7/18] (AB93567)

Flow Cyt

Unknown

Flow Cytometry - PE Anti-CD105 antibody [MJ7/18] (AB93567)

Staining of bEnd.3 (Mouse brain endothelioma cell line) whole cell lysate with 0.25 μg of PE Rat IgG2a Isotype Control (open histogram) or 0.25 μg of ab93567 (colored histogram). Total viable cells were used for analysis.

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

MJ7/18

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

標識

励起波長/蛍光波長

Ex: 480;565nm, Em: 578nm

キャリアフリー

交差種

Mouse

アプリケーション

Flow Cyt

applications

免疫原

Tissue preparation containing Eng protein. The exact immunogen used to generate this antibody is proprietary information.

Q63961

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.25-0.5 µg for 10^5-10^8 Cells", "FlowCyt-species-notes": "<p><a href='/products/unavailable/rat-igg2a-kappa-monoclonal-klhg2a-1-1-pe-isotype-control-ab134674'>ab134674</a> - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.2 Preservative: 0.09% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD105 also known as endoglin or the CD105 marker is a transmembrane glycoprotein with a molecular weight of approximately 180 kDa. It is a component of the TGF-beta receptor complex and exists in endothelial cells where it is abundantly expressed. Expression of CD105 is higher in proliferating cells particularly in the vasculature. You can also find it in tissues involved in the formation and remodeling of blood vessels such as during angiogenesis.

Biological function summary

Endoglin functions in the regulation of angiogenesis and vascular remodeling. It plays a significant role in mediating cellular responses to TGF-beta signaling influencing endothelial cell proliferation and migration. While not part of a larger structural complex endoglin interacts with receptors and signaling molecules important for vascular development and repair processes. This involvement aids in maintaining endothelial integrity and function under various physiological conditions.

Pathways

CD105 participates in the TGF-beta signaling and angiogenesis pathways. In these pathways it acts in conjunction with other proteins like TGF-beta receptors which play roles in cell differentiation proliferation and apoptosis. The interaction between CD105 and TGF-beta signaling regulates numerous cellular mechanisms impacting angiogenesis and cellular responses to environmental changes.

CD105 has links to hereditary hemorrhagic telangiectasia (HHT) and certain cancers. In HHT mutations in the endoglin gene alter vascular structure leading to the formation of abnormal blood vessels. Oncologically overexpression of CD105 is present in tumor angiogenesis aiding in the progression of certain cancers. Other proteins like VEGF and TGF-beta closely interact with endoglin influencing disease progression and presenting potential targets for therapeutic intervention.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed : 10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PubMed : 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PubMed : 10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PubMed : 28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed : 23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).

See full target information Eng

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文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular biochemistry 122:1791-1804 PubMed34397115

2021

Mesenchymal stem cell and endothelial progenitor cells coinjection improves LPS-induced lung injury via Tie2 activation and downregulation of the TLR4/MyD88 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sadaf Hoseinnia,Maryam Ghane,Jamile Norouzi,Farzaneh Hosseini

Nature communications 8:16074 PubMed28719575

2017

Non-canonical NOTCH3 signalling limits tumour angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Shuheng Lin,Ana Negulescu,Sirisha Bulusu,Benjamin Gibert,Jean-Guy Delcros,Benjamin Ducarouge,Nicolas Rama,Nicolas Gadot,Isabelle Treilleux,Pierre Saintigny,Olivier Meurette,Patrick Mehlen

Stem cells international 2014:576358 PubMed25302065

2014

Osteogenic Potential of Mouse Adipose-Derived Stem Cells Sorted for CD90 and CD105 In Vitro.

Applications

Flow Cyt

Species

Mouse

Maiko Yamamoto,Hidemi Nakata,Jia Hao,Joshua Chou,Shohei Kasugai,Shinji Kuroda

PloS one 8:e75383 PubMed24040409

2013

Amniotic fluid stem cells from EGFP transgenic mice attenuate hyperoxia-induced acute lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Shih-Tao Wen,Wei Chen,Hsiao-Ling Chen,Cheng-Wei Lai,Chih-Ching Yen,Kun-Hsiung Lee,Shinn-Chih Wu,Chuan-Mu Chen

Cancer research 67:10268-77 PubMed17974968

2007

A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis.

Applications

Species

Unspecified reactive species

Eduardo Pérez-Gómez,María Villa-Morales,Javier Santos,José Fernández-Piqueras,Carlos Gamallo,Javier Dotor,Carmelo Bernabéu,Miguel Quintanilla

Clinical cancer research : an official journal of the American Association for Cancer Research 13:323-30 PubMed17200371

2007

Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature.

Applications

IHC-Fr

Species

Unspecified reactive species

Grzegorz Korpanty,Juliet G Carbon,Paul A Grayburn,Jason B Fleming,Rolf A Brekken

Journal of immunology (Baltimore, Md. : 1950) 175:139-46 PubMed15972640

2005

Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.

Applications

IHC-Fr

Species

Unspecified reactive species

Takashi Onoe,Hideki Ohdan,Daisuke Tokita,Masayuki Shishida,Yuka Tanaka,Hidetaka Hara,Wendy Zhou,Kohei Ishiyama,Hiroshi Mitsuta,Kentaro Ide,Toshimasa Asahara

Oncogene 22:5976-85 PubMed12955076

2003

Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.

Applications

IHC-Fr, WB

Species

Unspecified reactive species, Unspecified reactive species

Miguel Quintanilla,Jose Ramón Ramirez,Eduardo Pérez-Gómez,Diana Romero,Beatriz Velasco,Michelle Letarte,Jose Miguel López-Novoa,Carmelo Bernabéu

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

PE Anti-CD105 抗体 [MJ7/18]

PE Anti-CD105 antibody [MJ7/18]

Flow Cytometry - PE Anti-CD105 antibody [MJ7/18] (AB93567)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (8)

Abcam product promise