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AB9704

Anti-PDGF BB 抗体

Anti-PDGF BB antibody

4

(2 Reviews)

|

(9 Publications)

Rabbit Polyclonal PDGF B antibody. Suitable for WB and reacts with Human samples. Cited in 9 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PDGFB.

別名を表示する

PDGF2, SIS, PDGFB, Platelet-derived growth factor subunit B, PDGF subunit B, PDGF-2, Platelet-derived growth factor B chain, Platelet-derived growth factor beta polypeptide, Proto-oncogene c-Sis

1 Images
Western blot - Anti-PDGF BB antibody (AB9704)
  • WB

Unknown

Western blot - Anti-PDGF BB antibody (AB9704)

The 29kDa form is the propeptide.

All lanes:

Western blot - Anti-PDGF BB antibody (ab9704) at 0.2 µg/mL

All lanes:

A-431 (Human) Whole Cell Lysate (ab52255) at 10 µg

Secondary

All lanes:

Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Predicted band size: 27 kDa

Observed band size: 18 kDa,29 kDa,45 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

Unknown

軽鎖のタイプ

unknown

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human PDGFB.

P01127

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p>To detect hPDGF-BB by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 µg/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hPDGF-BB is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.</p>" } } }
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下記製品もご検討ください

AB178409

Anti-PDGF B antibody [EPR6834]

0
0 Reviews
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こちらの製品も推奨する理由

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製品の詳細

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出荷温度及び保存条件

製品の状態
Lyophilized
再構成
reconstitute with water at 200µL
精製方法
Affinity purification Immunogen
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PDGF-B also known as platelet-derived growth factor subunit B or PDGF-BB is a critical protein involved in various cellular processes. Composed of 241 amino acids PDGF-B exhibits a molecular mass of approximately 27 kDa. Scientists recognize this protein for its expression primarily in platelets but it also appears in a range of other tissues including smooth muscle cells and fibroblasts. The PDGF-B protein plays a substantial role in the regulation of growth and division inducing pathways important for cellular proliferation.
Biological function summary

PDGF-B influences cellular signaling processes and facilitates interactions that are a part of the PDGF receptor system. PDGF-B can form a homo-dimerization commonly known as the PDGF-BB dimer which is an active form. When PDGF-B binds to its receptor specifically the PDGF receptor β (PDGFR-β) it triggers pathways that control various cellular activities including growth and survival. The interaction of PDGF-B with the receptor is an important step that modulates several downstream signaling pathways.

Pathways

PDGF-B activates significant pathways such as the MAPK/ERK and PI3K/AKT pathways. These pathways play a major role in the regulation of cell proliferation and differentiation. Through these pathways PDGF-B exhibits interactions with proteins like Ras and Akt which are integral in transmitting signals within the cell. These cascades result in the promotion of processes such as angiogenesis and wound healing highlighting the importance of PDGF-B in cellular function.

Researchers have linked PDGF-B to pathologies such as cancer and atherosclerosis. For instance overexpression of PDGF-B can lead to abnormal vascular growth contributing to tumor development in cancers. It also plays a role in the progression of atherosclerosis by promoting the migration and proliferation of smooth muscle cells leading to plaque formation. In these contexts PDGF-B shows interaction with other proteins such as VEGF in tumor angiogenesis and LDL in atherosclerotic developments reinforcing its involvement in these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed : 26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
See full target information PDGFB
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文献 (9)

Recent publications for all applications. Explore the full list and refine your search

Cell death discovery 8:160 PubMed35379779

2022

Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Bojie Lin,Dan Huang,Guanyu Lin,Yong Miao,Jin Wang,Zhexiang Fan,Zhiqi Hu

PloS one 16:e0260130 PubMed34965258

2021

The involvement of TGF-β1 /FAK/α-SMA pathway in the antifibrotic impact of rice bran oil on thioacetamide-induced liver fibrosis in rats.

Applications

Unspecified application

Species

Unspecified reactive species

Rehab F Abdel-Rahman,Hany M Fayed,Gihan F Asaad,Hanan A Ogaly,Alyaa F Hessin,Abeer A A Salama,Sahar S Abd El-Rahman,Mahmoud S Arbid,Marawan Abd Elbaset Mohamed

Stem cell research & therapy 11:444 PubMed33076979

2020

DNMT1-mediated methylation inhibits microRNA-214-3p and promotes hair follicle stem cell differentiate into adipogenic lineages.

Applications

Unspecified application

Species

Unspecified reactive species

Fangcao Jin,Min Li,Xuyang Li,Yunpeng Zheng,Kun Zhang,Xiaojun Liu,Bingjie Cai,Guangwen Yin

Molecular medicine reports 22:886-894 PubMed32467985

2020

TIM‑3 inhibits PDGF‑BB‑induced atherogenic responses in human artery vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Lian,Zhecun Wang,Jiacong Qiu,Baohong Jiang,Junbing Lv,Rongzhou He,Ruiming Liu,Wen Li,Jinsong Wang,Shenming Wang

Scientific reports 6:19404 PubMed26762853

2016

Endothelial Cords Promote Tumor Initial Growth prior to Vascular Function through a Paracrine Mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Chengjian Zhao,Wei Zhang,Yuwei Zhao,Yun Yang,Hui Luo,Gaili Ji,E Dong,Hongxing Deng,Shuo Lin,Yuquan Wei,Hanshuo Yang

Electrophoresis 36:2017-26 PubMed26010067

2015

Exosome enrichment of human serum using multiple cycles of centrifugation.

Applications

Unspecified application

Species

Unspecified reactive species

Jeongkwon Kim,Zhijing Tan,David M Lubman

The European respiratory journal 37:968-70 PubMed21454902

2011

An autopsy case of pulmonary veno-occlusive disease refractory to imatinib.

Applications

Unspecified application

Species

Unspecified reactive species

H Koiwa,I Tsujino,D Ikeda,H Ohira,M Tanino,M Nishimura

Biosensors & bioelectronics 25:1717-22 PubMed20047825

2010

Electrochemical detection of vascular endothelial growth factors (VEGFs) using VEGF antibody fragments modified Au NPs/ITO electrode.

Applications

Unspecified application

Species

Unspecified reactive species

Gang-Il Kim,Kyung-Woo Kim,Min-Kyu Oh,Yun-Mo Sung

Blood 115:51-60 PubMed19880494

2009

Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.

Applications

Neut

Species

Human

Jun Yang,Xin Liu,Susan B Nyland,Ranran Zhang,Lindsay K Ryland,Kathleen Broeg,Kendall Thomas Baab,Nancy Ruth Jarbadan,Rosalyn Irby,Thomas P Loughran
View all publications
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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