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AB168432

Anti-PDE9A 抗体

Anti-PDE9A antibody

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(2 Publications)

Mouse Polyclonal PDE9A antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PDE9A.

別名を表示する

PDE9A

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-PDE9A antibody (AB168432)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PDE9A antibody (AB168432)

Immunofluorescence analysis of HeLa cells labeling PDE9A with ab168432 at 10μg/ml.

Western blot - Anti-PDE9A antibody (AB168432)
  • WB

Unknown

Western blot - Anti-PDE9A antibody (AB168432)

All lanes:

Western blot - Anti-PDE9A antibody (ab168432) at 1 µg/mL

Lane 1:

PDE9A transfected 293T lysate at 15 µL

Lane 2:

Non-transfected 293T lysate at 15 µL

Predicted band size: 68 kDa

false

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human PDE9A.

O76083

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PDE9A is a phosphodiesterase enzyme that breaks down cyclic guanosine monophosphate (cGMP) into non-cyclic GMP therefore regulating intracellular levels of cGMP. This enzyme has a molecular mass of approximately 65 kilodaltons. Researchers often refer to PDE9A also as phosphodiesterase 9A. It shows higher expression in the brain and heart with presence also noted in the kidneys and lungs.
Biological function summary

PDE9A regulates the signaling processes by controlling cGMP turnover. It functions as a part of a larger network of proteins involved in intracellular signal transduction. PDE9A does not typically form distinct complexes but interacts with signaling components to maintain balanced cGMP concentrations which is essential for signaling related to vasodilation and platelet aggregation.

Pathways

PDE9A influences both cardiovascular and central nervous system pathways. In the cardiovascular system it interacts with nitric oxide signaling which has connections to blood pressure regulation through vasodilation. Within the CNS PDE9A is involved in synaptic plasticity relating to proteins like phosphodiesterase PDE5 and PDE2 which also handle cyclic nucleotide breakdown affecting neurotransmitter signaling and learning processes.

PDE9A has connections to conditions like heart failure and Alzheimer’s disease. In heart failure PDE9A’s regulation of cGMP affects nitric oxide signaling and cardiac function. In Alzheimer’s disease its influence on synaptic plasticity through interactions with proteins like amyloid precursor protein (APP) suggests a role in cognitive decline making it a potential therapeutic target for modulating synaptic signaling and cognitive function.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific : compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed : 18757755, PubMed : 21483814, PubMed : 9624146). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed : 25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
See full target information PDE9A
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 44:1249-1273 PubMed39806097

2025

E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Hao,Zhengwei Hu,Mengjie Li,Shuo Zhang,Mibo Tang,Chenwei Hao,Shasha Qi,Yuanyuan Liang,Michael F Almeida,Kaitlan Smith,Chunyan Zuo,Yanmei Feng,Mengnan Guo,Dongrui Ma,Shuangjie Li,Zhiyun Wang,Yuemeng Sun,Zhifen Deng,Chengyuan Mao,Zongping Xia,Yong Jiang,Yanxia Gao,Yuming Xu,Jonathan C Schisler,Changhe Shi

The Journal of biological chemistry 300:107783 PubMed39303913

2024

Downregulation of the mA reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixin Yin,Lifang Ma,Xiaoting Tian,Qi Sun,Congcong Zhang,Yikun Wang,Yayou Miao,Xiangfei Xue,Yongjie Wang,Jiayi Wang,Xiao Zhang,Xumin Hou
View all publications
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