Anti-PDE7A/HCP1 抗体 (ab14616)
Key features and details
- Rabbit polyclonal to PDE7A/HCP1
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
製品の概要
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製品名
Anti-PDE7A/HCP1 antibody
PDE7A/HCP1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to PDE7A/HCP1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat -
免疫原
Synthetic peptide corresponding to PDE7A/HCP1.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.02% Thimerosal (merthiolate) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab14616の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500. Detects a band of approximately 53 kDa (predicted molecular weight: 55 kDa).
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特記事項 |
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WB
1/500. Detects a band of approximately 53 kDa (predicted molecular weight: 55 kDa). |
ターゲット情報
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機能
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. -
組織特異性
PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart. -
パスウェイ
Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. -
配列類似性
Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. -
発生段階
Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle. -
ドメイン
Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. -
細胞内局在
Cytoplasm > cytosol. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions and Cytoplasm. PDE7A2 (50 kDa) is located to particulate cellular fractions. - Information by UniProt
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参照データベース
- Entrez Gene: 81744 Rat
- SwissProt: O08593 Rat
- Unigene: 39142 Rat
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別名
- 5''-cyclic phosphodiesterase 7A antibody
- HCP 1 antibody
- HCP1 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab14616 は 3 報の論文で使用されています。
- Zhang X & Dong S Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis. Biosci Biotechnol Biochem N/A:N/A (2021). PubMed: 34077501
- Wang H et al. Long non-coding RNA HOTAIR knockdown alleviates lipopolysaccharide-induced acute respiratory distress syndrome and the associated inflammatory response by modulating the microRNA-30a-5p/PDE7A axis. Exp Ther Med 22:1160 (2021). PubMed: 34504605
- Riopel M et al. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Mol Metab 41:101039 (2020). PubMed: 32534258