Anti-PDE4D3 抗体 (ab14614)
Key features and details
- Rabbit polyclonal to PDE4D3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-PDE4D3 antibody -
製品の詳細
Rabbit polyclonal to PDE4D3 -
由来種
Rabbit -
特異性
ab14614 does not cross react with PDE4D1, D2, D4 and D5. Does not cross react with PDE4A, PDE4B or PDE4C. -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to PDE4D3 (N terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.02% Sodium azide -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab14614の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500. Detects a band of approximately 93 kDa.
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| 特記事項 |
|---|
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WB
1/500. Detects a band of approximately 93 kDa. |
ターゲット情報
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関連性
Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype-variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype-variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short-term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein-protein interactions with cytoskeletal scaffolding proteins. -
細胞内局在
Cell Membrane and Cytoplasmic -
参照データベース
- Entrez Gene: 5144 Human
- Omim: 600129 Human
- SwissProt: Q08499 Human
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別名
- DPDE3 antibody
- hPDE4D3 antibody
- HSPDE4D antibody
see all
画像
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Western blot - Anti-PDE4D3 antibody (ab14614)
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab14614 は 3 報の論文で使用されています。
- Peng S et al. Phosphodiesterase 4 Inhibitor Roflumilast Protects Rat Hippocampal Neurons from Sevoflurane Induced Injury via Modulation of MEK/ERK Signaling Pathway. Cell Physiol Biochem 45:2329-2337 (2018). PubMed: 29550808
- Rababa'h A et al. Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol 425:3277-88 (2013). PubMed: 23806656
- Raymond DR et al. Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes. Am J Physiol Heart Circ Physiol 296:H263-71 (2009). WB ; Human . PubMed: 19060129
