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AB197377

Anti-PCP4 抗体

Anti-PCP4 antibody

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(5 Publications)

Rabbit Polyclonal PCP4 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Fusion protein corresponding to PCP4, fused to PCP4.

別名を表示する

PEP19, PCP4, Calmodulin regulator protein PCP4, Brain-specific polypeptide PEP-19, Purkinje cell protein 4

1 Images
Western blot - Anti-PCP4 antibody (AB197377)
  • WB

Supplier Data

Western blot - Anti-PCP4 antibody (AB197377)

12% SDS-PAGE

All lanes:

Western blot - Anti-PCP4 antibody (ab197377) at 1/1000 dilution

All lanes:

mouse brain lysate at 40 µg

Predicted band size: 7 kDa

false

Exposure time: 2min

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

WB

applications

免疫原

Fusion protein corresponding to PCP4, fused to PCP4. The exact immunogen used to generate this antibody is proprietary information.

P48539

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

PCP4 also known as Purkinje cell protein 4 functions as a calcium-binding protein predominantly involved in the regulation of calmodulin signaling. It weighs approximately 7 kDa and exhibits a high expression in the central nervous system especially in Purkinje cells of the cerebellum. PCP4 also shows expression in the hippocampus and other brain regions suggesting its role in neuronal activities and functions.
Biological function summary

PCP4 regulates calcium-dependent signaling pathways by interacting with calmodulin. It plays an important role in modulating neural signaling and plasticity impacting synaptic function and neuronal communication. PCP4 is not part of a large complex instead it works directly with calmodulin to influence calcium dynamics therefore affecting various neuronal processes.

Pathways

PCP4 participates actively in calcium-signaling pathways which impact neuronal excitability and synaptic transmission. It closely interacts through these pathways with calmodulin potentially affecting other downstream effectors like kinase enzymes. By modulating these pathways PCP4 influences neurotransmission and can alter neuronal circuit functions which is important for learning and memory processes.

PCP4 has a significant link with certain neurological conditions including schizophrenia and autism spectrum disorders. Changes in the expression or mutation of PCP4 impact neuronal signaling and excitability contributing to the pathology of these conditions. PCP4's interaction with calmodulin may also influence these diseases as altered calcium-signaling dynamics are often observed in these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed : 19106096, PubMed : 23204517, PubMed : 27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed : 21491429).
See full target information PCP4
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Bioengineered 13:2181-2193 PubMed35030971

2022

Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis.

Applications

Unspecified application

Species

Unspecified reactive species

Weifu He,Xiaoyan Shi,Zhenye Guo,Huan Wang,Mingming Kang,Zhi Lv

Human molecular genetics 29:1658-1672 PubMed32307524

2020

ALS-associated genes in SCA2 mouse spinal cord transcriptomes.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel R Scoles,Warunee Dansithong,Lance T Pflieger,Sharan Paul,Mandi Gandelman,Karla P Figueroa,Frank Rigo,C Frank Bennett,Stefan M Pulst

Molecular therapy. Nucleic acids 20:345-358 PubMed32199130

2020

miR-122 Exerts Inhibitory Effects on Osteoblast Proliferation/Differentiation in Osteoporosis by Activating the PCP4-Mediated JNK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Chen Meng,Tao Lin,Heng Jiang,Zheng Zhang,Lun Shu,Jia Yin,Xiao Ma,Ce Wang,Rui Gao,Xu-Hui Zhou

Nature communications 9:3648 PubMed30194296

2018

Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Sharan Paul,Warunee Dansithong,Karla P Figueroa,Daniel R Scoles,Stefan M Pulst

Nature 544:362-366 PubMed28405024

2017

Antisense oligonucleotide therapy for spinocerebellar ataxia type 2.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel R Scoles,Pratap Meera,Matthew D Schneider,Sharan Paul,Warunee Dansithong,Karla P Figueroa,Gene Hung,Frank Rigo,C Frank Bennett,Thomas S Otis,Stefan M Pulst
View all publications
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