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AB234415

Anti-Parathyroid Hormone 抗体 [rPTH/911]

Anti-Parathyroid Hormone antibody [rPTH/911]

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(2 Publications)

Mouse Recombinant Monoclonal Parathyroid Hormone antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Parathyroid hormone.

別名を表示する

Parathyroid hormone, PTH, Parathormone, Parathyrin

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [rPTH/911] (AB234415)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [rPTH/911] (AB234415)

Formalin-fixed, paraffin-embedded human parathyroid tissue stained for Parathyroid Hormone using ab234415 at 1 μg/ml in immunohistochemical analysis.

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-Parathyroid Hormone antibody [rPTH/911] - BSA and Azide free

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

rPTH/911

アイソタイプ

IgG2b

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human Parathyroid hormone. The exact immunogen used to generate this antibody is proprietary information.

P01270

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代替製品

Primary Antibodies

AB218497

Anti-Parathyroid Hormone antibody [PTH/1717R] - N-terminal

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [PTH/1717R] - N-terminal (AB218497)

  • 0
  • 0
Primary Antibodies

AB130759

Anti-Parathyroid Hormone antibody [SP151]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [SP151] (AB130759)

  • 0
  • 0
Primary Antibodies

AB213557

Anti-Parathyroid Hormone antibody [EPR20598]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [EPR20598] (AB213557)

  • 0
  • 0
Primary Antibodies

AB166631

Anti-Parathyroid Hormone antibody [EPR8480]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [EPR8480] (AB166631)

  • 0
  • 0
Primary Antibodies

AB166632

Anti-Parathyroid Hormone antibody [EPR8481]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [EPR8481] (AB166632)

  • 0
  • 0
Primary Antibodies

AB154792

Anti-Parathyroid Hormone antibody [EPR9939]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [EPR9939] (AB154792)

  • 5
  • 1
Primary Antibodies

AB236229

Anti-Parathyroid Hormone antibody [SP151] - BSA and Azide free

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Parathyroid Hormone antibody [SP151] - BSA and Azide free (AB236229)

  • 0
  • 0

組合せ製品

Assay Kits

AB230931

Human PTH ELISA Kit

Recombinant|SimpleStep

ELISA - Human PTH ELISA Kit (AB230931)

  • 0
  • 0
Primary Antibodies

AB237709

Anti-CD8 alpha antibody [CAL66]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD8 alpha antibody [CAL66] (AB237709)

  • 5
  • 2
Primary Antibodies

AB64085

Anti-TMEM16A antibody [SP31]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-TMEM16A antibody [SP31] (AB64085)

  • 3
  • 2
Primary Antibodies

AB99889

Anti-MSH6 antibody [SP93]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-MSH6 antibody [SP93] (AB99889)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>Primary incubation for 30 minutes at room temperature.</p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Parathyroid hormone (PTH) also known as the parathyrin is a hormone protein with a molecular mass of about 9.4 kDa. It is synthesized and secreted by the chief cells of the parathyroid glands. PTH plays an important role in regulating calcium levels in the blood. Its molecular action involves binding to PTH receptors which are mainly located in bones and kidneys to increase calcium concentration by promoting its release from bones and reabsorption in the kidneys. This hormone is also present in the bloodstream as a parathyroid hormone peptide.
Biological function summary

PTH regulates calcium and phosphate metabolism in the body. It does not function as part of a larger complex but acts independently to control these important minerals. The hormone affects osteoclast activity in bones enhancing calcium and phosphate release. Additionally in the kidneys it reduces phosphate reabsorption while increasing calcium reabsorption. This balance maintained by PTH is essential for bone health and metabolic functions often associated with parathyroid hormone-related proteins in its activity.

Pathways

PTH is integral to the calcium signaling pathway and the renal phosphate reabsorption pathway. PTH works in concert with vitamin D to enhance intestinal calcium absorption. Calcitriol the active form of vitamin D depends on PTH for its synthesis in the kidneys linking the two in calcium homeostasis. Through these pathways PTH also interacts with the calcitonin hormone to moderate calcium levels creating a balance between mineral deposition and resorption in bones.

PTH is closely associated with hyperparathyroidism and hypoparathyroidism known as pan hypoparathyroidism when complete underactivity of the parathyroid glands occurs. In hyperparathyroidism an overproduction of PTH leads to high blood calcium levels and associated symptoms. Conversely hypoparathyroidism results in low calcium levels due to insufficient PTH secretion. Both conditions affect calcium metabolism and relate to proteins like calcium-sensing receptor and PTH-related peptide highlighting how critical PTH's function is in endocrine and metabolic health.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion (PubMed : 11604398, PubMed : 35932760). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (PubMed : 18375760, PubMed : 35932760). Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (PubMed : 21076856).
See full target information Parathyroid hormone
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 15:3394-3405 PubMed38817869

2024

CD52 knockdown inhibits aerobic glycolysis and malignant behavior of NSCLC cells through AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yini Cai,Jiali Zhao,Chen Luo,Ming Fang,Yanling Yi,Yu Chen,Peng Huang,Lingmin Liao,Long Huang

Medicine 101:e32009 PubMed36482540

2022

Production of parathyroid-like cells from thyroid stem cells in co-culture environment.

Applications

Unspecified application

Species

Unspecified reactive species

Özge Karabiyik Acar,Gülçin Delal Nozhatzadeh,Alperen Tuncer,Gamze Torun Köse,Ezgi Hacihasanoğlu,Fikrettin Sahin,Erhan Aysan
View all publications
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Abcam product promise

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