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Anti-PACAP receptor/ADCYAP1R1 抗体 (ab28670)

Reviews (1)Q&A (1)References (6)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (ab28670)

    Key features and details

    • Rabbit polyclonal to PACAP receptor/ADCYAP1R1
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    製品の概要

    • 製品名

      Anti-PACAP receptor/ADCYAP1R1 antibody
      PACAP receptor/ADCYAP1R1 一次抗体 製品一覧

    • 製品の詳細

      Rabbit polyclonal to PACAP receptor/ADCYAP1R1

    • 由来種

      Rabbit

    • アプリケーション

      適用あり: IHC-Pmore details

    • 種交差性

      交差種: Human
      交差が予測される動物種: Mouse, Rat, Cow

    • 免疫原

      Synthetic peptide corresponding to Human PACAP receptor/ADCYAP1R1 aa 400-500 conjugated to keyhole limpet haemocyanin.
      Database link: P41586

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

    • ポジティブ･コントロール

      • IHC-P: Human myenteric ganglia cells of the small intestine.

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab28670の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    IHC-P
    1/500.
    特記事項
    IHC-P
    1/500.

    ターゲット情報

    • 機能

      This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

    • 組織特異性

      Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

    • 配列類似性

      Belongs to the G-protein coupled receptor 2 family.

    • 細胞内局在

      Cell membrane.
    • Information by UniProt

    • 参照データベース

      see all

    • 別名

      • ADCYAP1 R1 antibody
      • ADCYAP1R 1 antibody
      • ADCYAP1R1 antibody
      • Adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1 antibody
      • Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I antibody
      • PAC 1 antibody
      • PAC1 antibody
      • PAC1R antibody
      • PACAP receptor 1 antibody
      • PACAP type I receptor antibody
      • PACAP-R-1 antibody
      • PACAP-R1 antibody
      • PACAP1 R antibody
      • PACAPR antibody
      • PACAPRI antibody
      • PACR_HUMAN antibody
      • Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop antibody
      • Pituitary adenylate cyclase activating polypeptide receptor antibody
      • Pituitary adenylate cyclase activating polypeptide type I receptor precursor antibody
      • Pituitary adenylate cyclase-activating polypeptide 1, receptor for antibody
      • Pituitary adenylate cyclase-activating polypeptide type I receptor antibody
      • pvr1 antibody
      see all

    画像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (ab28670)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (ab28670)

      ab28670 staining Human PACAP receptor/ADCYAP1R1 in human myenteric ganglia cells of the small intestine by immunohistochemistry using paraffin embedded tissue.

    参考文献 (6)

    ab28670 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab28670 は 6 報の論文で使用されています。

    • Zhang L  et al. PACAP6-38 improves nitroglycerin-induced central sensitization by modulating synaptic plasticity at the trigeminal nucleus caudalis in a male rat model of chronic migraine. J Headache Pain 24:66 (2023). PubMed: 37271806
    • Fan G  et al. A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model. Acta Biochim Biophys Sin (Shanghai) 54:1349-1364 (2022). PubMed: 36082935
    • Frausto RF  et al. ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing. PLoS One 14:e0218279 (2019). PubMed: 31194824
    • Frederiksen SD  et al. Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans. Neuroscience 393:319-332 (2018). PubMed: 30336190
    • Rice FL  et al. Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine. Cephalalgia 37:1350-1372 (2017). PubMed: 27852962
    • Ortner A  et al. VPAC receptor mediated tumor cell targeting by protamine based nanoparticles. J Drug Target 18:457-67 (2010). ICC ; Human . PubMed: 20050817

    レビューと Q&A

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    1-2 of 2 Abreviews or Q&A

    Western blot abreview for Anti-PACAP receptor antibody

     Average
    Abreviews
    abreview image
    Application
    Western blot
    Loading amount
    25 µg
    Gel Running Conditions
    Reduced Denaturing (10% Gel)
    Sample
    Mouse Tissue lysate - whole (Dorsal Hippocampal Tissue)
    Specification
    Dorsal Hippocampal Tissue
    Blocking step
    I-Block as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 0.2% · Temperature: 20°C
    Read More
    The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

    Abcam user community

    Verified customer

    投稿 Oct 14 2013

    Question

    We have finished the RIA for an antibody ab8901 and we did the abreview for it (attached). Two things: First, there is no option to select Radio Immuno Assay when submitting an abreview on the website, so we cannot submit correctly because depending on what we select, it then asks a series of questions related to the specified application. Second, we only just realized that we did an abreview on a different antibody than the one you mentioned below.



    So we are wondering how can we submit? And whether this promo code is still good, even though we did a different antibody?

    Read More
    Answer

    Thank you for your reply.

    Because ab8901 has been validated for use in rat and RIA, it will be guaranteed for your experiments and would not qualify for the testing discount program. I would be happy to manually submit your Abreview and award you the Abpoints, if you could please send it to me? Unfortunately, I did not receive the attachment you tried to send.

    While the Abpoints will not be worth a free antibody, they can be redeemed for a value off of your next order or an Amazon.com gift card: https://www.abcam.com/index.html?pageconfig=loyalty_rewards_list

    Alternatively, if you submit an image of your results with your Abreview, I can offer you the testing discount program for submitting the image. In that case, I will issue you a different discount code that will be valid for reviewing ab8901. I look forward to processing your Abreview.

    Read More

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