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AB216664

Anti-PACAP receptor/ADCYAP1R1 抗体

Anti-PACAP receptor/ADCYAP1R1 antibody

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(1 Publication)

Rabbit Polyclonal PACAP receptor/ADCYAP1R1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Mouse Pituitary adenylate cyclase-activating polypeptide type I receptor aa 250-300 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

Pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP type I receptor, PACAP-R-1, PACAP-R1

2 Images
Western blot - Anti-PACAP receptor/ADCYAP1R1 antibody (AB216664)
  • WB

Supplier Data

Western blot - Anti-PACAP receptor/ADCYAP1R1 antibody (AB216664)

12% gel

All lanes:

Western blot - Anti-PACAP receptor/ADCYAP1R1 antibody (ab216664) at 1/200 dilution

Lane 1:

Rat brain lysate

Lane 2:

Rat heart lysate

Secondary

All lanes:

Goat anti-rabbit IgG (H+L), HRP-conjugated at 1/3000 dilution

Predicted band size: 53 kDa

Observed band size: 58 kDa

true

Western blot - Anti-PACAP receptor/ADCYAP1R1 antibody (AB216664)
  • WB

Supplier Data

Western blot - Anti-PACAP receptor/ADCYAP1R1 antibody (AB216664)

All lanes:

Western blot - Anti-PACAP receptor/ADCYAP1R1 antibody (ab216664) at 1/300 dilution

Lane 1:

Mouse brain lysate

Lane 2:

A549 cell lysate

Predicted band size: 46 kDa,53 kDa,54 kDa,58 kDa,67 kDa

Observed band size: 55 kDa,61 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat, Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Mouse Pituitary adenylate cyclase-activating polypeptide type I receptor aa 250-300 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P70205

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代替製品

Primary Antibodies

AB183103

Anti-PACAP receptor/ADCYAP1R1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB183103)

  • 0
  • 0
Primary Antibodies

AB28670

Anti-PACAP receptor/ADCYAP1R1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB28670)

  • 3
  • 1
Primary Antibodies

AB140703

Anti-PACAP receptor/ADCYAP1R1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB140703)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB216627

Anti-PACAP-38 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP-38 antibody (AB216627)

  • 0
  • 0
Primary Antibodies

AB28624

Anti-VPAC2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VPAC2 antibody (AB28624)

  • 4
  • 2
Primary Antibodies

AB123517

Anti-VPAC1 antibody

Western blot - Anti-VPAC1 antibody (AB123517)

  • 0
  • 0
Primary Antibodies

AB8556

Anti-VIP antibody

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The PACAP receptor also known as ADCYAP1R1 is a G-protein-coupled receptor that interacts with the neuropeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide). This receptor plays a role in transmitting extracellular signals into cellular responses. It is comprised of approximately 525 amino acids with a considerable molecular mass of around 59 kDa. The PACAP receptors are widely expressed in the central nervous system including regions like the hypothalamus hippocampus and cerebellum. It also appears in peripheral tissues such as the adrenal glands and testis.
Biological function summary

PACAP receptor plays significant roles in both neuronal and endocrine systems. It modulates neurotransmitter release and affects neurotrophic activities. The receptor often operates in a receptor-ligand complex with PACAP which enables it to participate in neuroprotective and neurite outgrowth functions. This receptor actively regulates activities within the hypothalamic-pituitary-adrenal axis impacting stress responses and circadian rhythms.

Pathways

Many processes involve the PACAP receptor through essential signaling pathways like the cAMP-PKA and MAPK pathways. These pathways integrate signals from multiple receptor types including glucocorticoid receptors. The PACAP receptor often interacts with other adenylyl cyclase-activating proteins enhancing its involvement in neural cAMP synthesis and related functions. This places the receptor within key pathways regulating brain development and neuroplasticity.

The PACAP receptor holds connections to both mental health and neurological conditions. Its abnormal function has associations with disorders such as anxiety-related disorders and migraine. The receptor's relationship with proteins like the CRH (Corticotropin-Releasing Hormone) receptor further implicates its role in the pathophysiology of stress-induced disorders. Targeting PACAP receptors can thereby offer therapeutic potential in the management of these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds both PACAP27 and PACAP38 bioactive peptides. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
See full target information Pituitary adenylate cyclase-activating polypeptide type I receptor
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 24:726 PubMed36340606

2022

ASPP2 promotes cell apoptosis in cervical cancer through inhibiting autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Feiyun Jiang,Ganxia Bian,Jiehua Li
View all publications
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Abcam product promise

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