AB140703

Anti-PACAP receptor/ADCYAP1R1 抗体

Name: Anti-PACAP receptor/ADCYAP1R1 抗体 (ab140703) | Abcam
Brand: Abcam Limited
SKU: AB140703
Price: 90000 JPY
Availability: InStock

Anti-PACAP receptor/ADCYAP1R1 antibody

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(2 Publications)

Rabbit Polyclonal PACAP receptor/ADCYAP1R1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Pituitary adenylate cyclase-activating polypeptide type I receptor.

別名を表示する

Pituitary adenylate cyclase-activating polypeptide type I receptor, PAC1 receptor, PAC1R, PACAP type I receptor, PACAP-R-1, PACAP-R1, ADCYAP1R1

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB140703)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB140703)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain pituitary tissue labelling PACAP receptor/ADCYAP1R1 with ab140703 after heat-induced antigen retrieval.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human Pituitary adenylate cyclase-activating polypeptide type I receptor. The exact immunogen used to generate this antibody is proprietary information.

P41586

特異性

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "7 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-80°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The PACAP receptor also known as ADCYAP1R1 is a G-protein-coupled receptor that interacts with the neuropeptide PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide). This receptor plays a role in transmitting extracellular signals into cellular responses. It is comprised of approximately 525 amino acids with a considerable molecular mass of around 59 kDa. The PACAP receptors are widely expressed in the central nervous system including regions like the hypothalamus hippocampus and cerebellum. It also appears in peripheral tissues such as the adrenal glands and testis.

Biological function summary

PACAP receptor plays significant roles in both neuronal and endocrine systems. It modulates neurotransmitter release and affects neurotrophic activities. The receptor often operates in a receptor-ligand complex with PACAP which enables it to participate in neuroprotective and neurite outgrowth functions. This receptor actively regulates activities within the hypothalamic-pituitary-adrenal axis impacting stress responses and circadian rhythms.

Pathways

Many processes involve the PACAP receptor through essential signaling pathways like the cAMP-PKA and MAPK pathways. These pathways integrate signals from multiple receptor types including glucocorticoid receptors. The PACAP receptor often interacts with other adenylyl cyclase-activating proteins enhancing its involvement in neural cAMP synthesis and related functions. This places the receptor within key pathways regulating brain development and neuroplasticity.

The PACAP receptor holds connections to both mental health and neurological conditions. Its abnormal function has associations with disorders such as anxiety-related disorders and migraine. The receptor's relationship with proteins like the CRH (Corticotropin-Releasing Hormone) receptor further implicates its role in the pathophysiology of stress-induced disorders. Targeting PACAP receptors can thereby offer therapeutic potential in the management of these conditions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed : 32047270, PubMed : 33715378, PubMed : 35477937, PubMed : 36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed : 32047270, PubMed : 35477937, PubMed : 36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed : 32047270, PubMed : 33715378, PubMed : 35477937, PubMed : 36385145). May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (PubMed : 32047270, PubMed : 33715378).

See full target information Pituitary adenylate cyclase-activating polypeptide type I receptor

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 23: PubMed36430275

2022

PAC, VPAC, and VPAC Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Zoe Tasma,Andrew Siow,Paul W R Harris,Margaret A Brimble,Simon J O'Carroll,Debbie L Hay,Christopher S Walker

Proceedings of the National Academy of Sciences of 112:E1659-68 PubMed25775528

2015

Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.

Applications

Unspecified application

Species

Unspecified reactive species

Abhishek Tripathi,P Geoff Vana,Tanmay S Chavan,Lioubov I Brueggemann,Kenneth L Byron,Nadya I Tarasova,Brian F Volkman,Vadim Gaponenko,Matthias Majetschak

View all publications

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Abcam product promise

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Anti-PACAP receptor/ADCYAP1R1 抗体

Anti-PACAP receptor/ADCYAP1R1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PACAP receptor/ADCYAP1R1 antibody (AB140703)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (2)

Abcam product promise