Anti-p40 - DeltaNp63 抗体 [BC28] (ab172731)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [BC28] (ab172731)](https://www.abcam.co.jp/ps/products/172/ab172731/Images/ab172731-250357-anti-p40-deltanp63-antibody-bc28-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [BC28] (ab172731)")
Key features and details
- Mouse monoclonal [BC28] to p40 - DeltaNp63
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-p40 - DeltaNp63 antibody [BC28]
p40 - DeltaNp63 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [BC28] to p40 - DeltaNp63 -
由来種
Mouse -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow
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免疫原
Synthetic peptide corresponding to Human p40 - DeltaNp63 aa 5-17.
Sequence:ENNAQTQFSEPQY
Database link: Q9H3D4 -
ポジティブ･コントロール
- IHC-P: Human lung squamous cell carcinoma.
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特記事項
This product was changed from ascites to tissue culture supernatant on 20/07/17. The following lots are from ascites and are still in stock as of [20/07/17] – [GR311007, GR322490]. Lot numbers higher than [GR322490] will be from tissue culture supernatant. Please note that the dilutions may need to be adjusted accordingly.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at +4°C. Do Not Freeze. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: bovine serum albumin -
Concentration information loading... -
精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
BC28 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab172731の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | (3) |
1/50 - 1/100. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.
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| 特記事項 |
|---|
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IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol. |
ターゲット情報
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関連性
Differentiating between lung adenocarcinoma and squamous cell carcinoma is an important distinction with therapeutic implications. Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types, particularly lymphomas. p40 is a relatively unknown marker that recognizes ?Np63-a p63 isoform suggested to be highly specific for squamous/basal cells. p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma. -
参照データベース
- SwissProt: Q9H3D4 Human
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別名
- 40 kDa Rab9 effector protein antibody
- 8430412M01Rik antibody
- 9530020d24rik antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody [BC28] (ab172731)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of lung squamous cell carcinoma labelling p40 - DeltaNp63 with ab172731 for 30 minutes at room temperature. Counterstained with hematoxylin.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (12)
ab172731 は 12 報の論文で使用されています。
- Kuroda N et al. Effectiveness of radiation therapy on brain invasion by human papillomavirus-related multiphenotypic sinonasal carcinoma: A case report. Neuropathology 42:45-51 (2022). PubMed: 34933397
- Kawachi H et al. Atezolizumab with bevacizumab, paclitaxel and carboplatin was effective for patients with SMARCA4-deficient thoracic sarcoma. Immunotherapy 13:799-806 (2021). PubMed: 34030451
- Hattori T et al. Elevated expression of protease-activated receptor 1 via ?Np63 down-regulation contributes to nodal metastasis in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 50:163-170 (2021). PubMed: 32536459
- Ekpo P et al. Characterization of limbal explant sites: Optimization of stem cell outgrowth in in vitro culture. PLoS One 15:e0233075 (2020). PubMed: 32407348
- Ota T et al. Validity of using immunohistochemistry to predict treatment outcome in patients with non-small cell lung cancer not otherwise specified. J Cancer Res Clin Oncol 145:2495-2506 (2019). PubMed: 31494736