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AB228508

Anti-Oxytocin-neurophysin 1 抗体

Anti-Oxytocin-neurophysin 1 antibody

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(2 Publications)

Guinea pig Polyclonal Oxytocin-neurophysin 1 antibody. Suitable for IHC-Fr and reacts with Sheep samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human OXT aa 1-50.

別名を表示する

OT, OXT, Oxytocin-neurophysin 1, OT-NPI, MGC126890, MGC126892, Neurophysin 1, Neurophysin I, OT, OT NPI, OXT, Ocytocin, Oxytocin Neurophysin preproprotein, Oxytocin prepro (neurophysin I), Oxytocin prepropeptide

1 Images
Immunohistochemistry (Frozen sections) - Anti-Oxytocin-neurophysin 1 antibody (AB228508)
  • IHC-Fr

Supplier Data

Immunohistochemistry (Frozen sections) - Anti-Oxytocin-neurophysin 1 antibody (AB228508)

Frozen section of sheep hypothalamus tissue stained for Oxytocin-neurophysin 1 using ab228508 at 1/1000 dilution in immunohistochemical analysis, followed by a biotinylated secondary antibody.

Key facts

宿主種

Guinea pig

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Sheep

アプリケーション

IHC-Fr

applications

免疫原

Synthetic Peptide within Human OXT aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

P01178

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代替製品

Primary Antibodies

AB124771

Anti-Oxytocin-neurophysin 1 antibody [EPR4665]

RabMAb|Recombinant

ELISA - Anti-Oxytocin-neurophysin 1 antibody [EPR4665] (AB124771)

  • 0
  • 0

組合せ製品

Assay Kits

AB242248

Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit

Recombinant|SimpleStep

ELISA - Human Oxytocin-neurophysin 1 Prepropeptide ELISA Kit (AB242248)

  • 0
  • 0
Primary Antibodies

AB302667

Anti-c-Fos antibody [N486/32]

BOND RX™ Validated|Recombinant|Lab Essentials|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Fos antibody [N486/32] (AB302667)

  • 0
  • 0
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
Primary Antibodies

AB213708

Anti-Vasopressin antibody [EPR20602]

RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-Vasopressin antibody [EPR20602] (AB213708)

  • 0
  • 0
Primary Antibodies

AB177487

Anti-NeuN antibody [EPR12763] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Frozen sections) - Anti-NeuN antibody [EPR12763] - Neuronal Marker (AB177487)

  • 5
  • 75
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Mouse": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Horse": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Pig": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rabbit": { "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Sheep": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Lyophilized
再構成
reconstitute with water at 50µL
精製度
Whole antiserum
バッファー組成
pH: 7 - 7.4
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Oxytocin-neurophysin 1 also known as prepro-oxytocin-neurophysin I is a precursor protein with a molecular weight of approximately 20 kDa. This protein is expressed primarily in the hypothalamus and is involved in the synthesis and storage of the hormone oxytocin a peptide essential for various physiological processes. During synthesis the protein undergoes cleavage to separate oxytocin and neurophysin 1 a carrier protein that aids in the transport and stabilization of oxytocin in neurosecretory granules.
Biological function summary

Oxytocin-neurophysin 1 plays an important role in the regulation of social behaviors reproductive functions and fluid homeostasis. This precursor is not part of a larger protein complex but neurophysin 1 serves as an essential carrier that binds and transports oxytocin to its target sites in the body. Oxytocin itself functions as a neuromodulator and hormone exerting effects on the uterine muscles and mammary glands promoting childbirth and lactation.

Pathways

The biosynthesis and release of oxytocin-neurophysin 1 are closely associated with the hypothalamic neurosecretory pathways. These pathways involve the neurohypophysis where oxytocin is released into the bloodstream. Additionally oxytocin interacts with the G-protein-coupled receptor OXTR to elicit its physiological effects. V1a and V2 receptors alongside oxytocin play roles in various signaling pathways that affect metabolic and cardiovascular functions.

Dysregulation of oxytocin-neurophysin 1 has been linked to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and autism spectrum disorders. In these conditions altered levels of oxytocin affect fluid balance and social behavior. Additionally changes in oxytocin levels often in tandem with altered vasopressin regulation associate with the development and exacerbation of these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Neurophysin 1 specifically binds oxytocin.. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (PubMed : 18174156).
See full target information OXT
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Molecular metabolism 100:102220 PubMed40712884

2025

Oxytocin neurons in the paraventricular and supraoptic hypothalamic nuclei bidirectionally modulate food intake.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica J Rea,Clarissa M Liu,Anna M R Hayes,Rita Ohan,Grace M Schwartz,Alexander G Bashaw,Molly E Klug,Lea Decarie-Spain,Yedam Park,Alicia E Kao,Valery Grinevich,Scott E Kanoski

Hippocampus 35:e70003 PubMed39949067

2025

Perinatal Protein Restriction Induces Anhedonic-Like Behavior: Disturbed Hippocampal Neurotrophic Signaling and Neuronal Structural Plasticity in Adult Offspring.

Applications

Unspecified application

Species

Unspecified reactive species

María C Gutiérrez,Ramiro G Comas Mutis,María C Perondi,Gastón D Calfa,Analía Valdomero
View all publications
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