Anti-OXCT1/SCOT 抗体 (ab105320)
Key features and details
- Rabbit polyclonal to OXCT1/SCOT
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-OXCT1/SCOT antibody
OXCT1/SCOT 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to OXCT1/SCOT -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat
-
免疫原
Recombinant fragment corresponding to Human OXCT1/SCOT aa 171-434. (BC009001)
-
ポジティブ･コントロール
- Human fetal heart and brain lysates; Human fetal kidney tissue.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Lyophilized:Reconstitute in 200ul sterile water -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituent: 0.1% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab105320の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 56 kDa.
|
| IHC-P |
1/100 - 1/500.
|
| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 56 kDa. |
|
IHC-P
1/100 - 1/500. |
ターゲット情報
-
機能
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. -
組織特異性
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts. -
パスウェイ
Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. -
関連疾患
Succinyl-CoA:3-oxoacid CoA transferase deficiency -
配列類似性
Belongs to the 3-oxoacid CoA-transferase family. -
細胞内局在
Mitochondrion matrix. - Information by UniProt
-
参照データベース
- Entrez Gene: 5019 Human
- Entrez Gene: 67041 Mouse
- Entrez Gene: 690163 Rat
- Omim: 601424 Human
- SwissProt: P55809 Human
- SwissProt: Q9D0K2 Mouse
- SwissProt: B2GV06 Rat
- Unigene: 278277 Human
see all -
別名
- 3 oxoacid CoA transferase 1 antibody
- 3-oxoacid CoA-transferase 1 antibody
- EC 2.8.3.5 antibody
see all
画像
-
Western blot - Anti-OXCT1/SCOT antibody (ab105320)All lanes : Anti-OXCT1/SCOT antibody (ab105320) at 1/500 dilution
Lane 1 : Human fetal heart lysate
Lane 2 : Human fetal brain lysate
Predicted band size: 56 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OXCT1/SCOT antibody (ab105320)ab105320 at 1/100 dilution staining OXCT1/SCOT in Human fetal kidney tissue
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (7)
ab105320 は 7 報の論文で使用されています。
- Jiang L et al. Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer. Bioengineered 12:6559-6571 (2021). PubMed: 34559577
- Thai PN et al. Ketone Ester D-β-Hydroxybutyrate-(R)-1,3 Butanediol Prevents Decline in Cardiac Function in Type 2 Diabetic Mice. J Am Heart Assoc 10:e020729 (2021). PubMed: 34583524
- Assalin HB et al. miRNAs, target genes expression and morphological analysis on the heart in gestational protein-restricted offspring. PLoS One 14:e0210454 (2019). PubMed: 31034522
- Aghajani Nargesi A et al. Metabolic Syndrome Modulates Protein Import into the Mitochondria of Porcine Mesenchymal Stem Cells. Stem Cell Rev Rep 15:427-438 (2019). PubMed: 30338499
- Schnyder S et al. Muscle PGC-1a is required for long-term systemic and local adaptations to a ketogenic diet in mice. Am J Physiol Endocrinol Metab 312:E437-E446 (2017). PubMed: 28223292
- Svensson K et al. Skeletal muscle PGC-1a modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. FASEB J 30:1976-86 (2016). PubMed: 26849960
- Cong W et al. Metallothionein prevents diabetes-induced cardiac pathological changes, likely via the inhibition of succinyl-CoA:3-ketoacid coenzyme A transferase-1 nitration at Trp(374). Am J Physiol Endocrinol Metab 304:E826-35 (2013). PubMed: 23423173