Anti-Osteoprotegerin 抗体 (ab183910)
Key features and details
- Rabbit polyclonal to Osteoprotegerin
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
-
製品名
Anti-Osteoprotegerin antibody
Osteoprotegerin 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Osteoprotegerin -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide within Human Osteoprotegerin aa 1-67. The exact sequence is proprietary.
Database link: O00300 -
ポジティブ･コントロール
- Raji whole cell lysate; Mouse heart lysate; Cal27 xenograft.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.025% Proclin 300
Constituents: 79% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab183910の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 46 kDa.
|
|
| IHC-P |
1/100 - 1/1000.
|
| 特記事項 |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 46 kDa. |
|
IHC-P
1/100 - 1/1000. |
ターゲット情報
-
機能
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. -
組織特異性
Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung. -
関連疾患
Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast-mediated skeletal resorption, the disease can be fatal. -
配列類似性
Contains 2 death domains.
Contains 4 TNFR-Cys repeats. -
翻訳後修飾
N-glycosylated. Contains sialic acid residues.
The N-terminus is blocked. -
細胞内局在
Secreted. - Information by UniProt
-
参照データベース
- Entrez Gene: 4982 Human
- Entrez Gene: 18383 Mouse
- Omim: 602643 Human
- SwissProt: O00300 Human
- SwissProt: O08712 Mouse
- Unigene: 81791 Human
- Unigene: 15383 Mouse
-
別名
- MGC29565 antibody
- OCIF antibody
- OPG antibody
see all
画像
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Osteoprotegerin antibody (ab183910)
Immunohistochemical analysis of paraffin-embedded Cal27 xenograft labeling OPG with ab183910 at 1/500 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0 for 15 min.
-
Western blot - Anti-Osteoprotegerin antibody (ab183910)Anti-Osteoprotegerin antibody (ab183910) at 1/1000 dilution + Mouse heart lysate at 50 µg
Predicted band size: 46 kDa10% SDS-PAGE
-
Western blot - Anti-Osteoprotegerin antibody (ab183910)Anti-Osteoprotegerin antibody (ab183910) at 1/1000 dilution + Raji whole cell lysate at 30 µg
Predicted band size: 46 kDa10% SDS-PAGE
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (31)
ab183910 は 31 報の論文で使用されています。
- Kisielowski K et al. Prognostic relevance of clinicopathological factors in sporadic and syndromic odontogenic keratocysts: A comparative study. Adv Clin Exp Med 32:245-259 (2023). PubMed: 36226690
- Tang LD et al. Iridoid from Eucommia ulmoides Oliv. Exerts Antiarthritis Effects by Inhibiting the JAK2/STAT3 Signaling Pathway In Vivo and In Vitro. Evid Based Complement Alternat Med 2023:4167906 (2023). PubMed: 37123081
- Lv H et al. A static magnetic field improves bone quality and balances the function of bone cells with regulation on iron metabolism and redox status in type 1 diabetes. FASEB J 37:e22985 (2023). PubMed: 37249350
- de Kort WWB et al. Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids. J Clin Med 12:N/A (2023). PubMed: 37762975
- Yu X et al. LncRNA SNHG1 modulates adipogenic differentiation of BMSCs by promoting DNMT1 mediated Opg hypermethylation via interacting with PTBP1. J Cell Mol Med 26:60-74 (2022). PubMed: 34854215