Anti-Orexin A 抗体 (ab35337)
Key features and details
- Sheep polyclonal to Orexin A
- Suitable for: IHC-FoFr
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Orexin A antibody
Orexin A 一次抗体 製品一覧 -
製品の詳細
Sheep polyclonal to Orexin A -
由来種
Sheep -
アプリケーション
適用あり: IHC-FoFrmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat
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免疫原
Synthetic peptide corresponding to Human Orexin A aa 35-47 conjugated to Keyhole Limpet Haemocyanin (KLH). corresponding to amino acids 2-14 of human orexin A peptide
Sequence:NLPSTKVSWAAVT
Database link: O43612 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
IgG fraction -
特記事項（精製）
Ammonium Sulfate fractionation. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab35337の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-FoFr |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
IHC-FoFr
Use at an assay dependent concentration. |
ターゲット情報
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関連性
Orexin A (hypocretin 1) a 33 amino acid peptide and orexin B (hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro orexin. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behaviour. Orexin A and orexin B bind to and activate two closely related G protein coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Dysfunction of the orexin peptide system has been linked to narcolepsy. -
細胞内局在
Rough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. -
参照データベース
- Entrez Gene: 3060 Human
- Entrez Gene: 25723 Rat
- Omim: 602358 Human
- SwissProt: O43612 Human
- SwissProt: O55232 Rat
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別名
- HCRT antibody
- HCRT1 antibody
- HCRT2 antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab35337 は 1 報の論文で使用されています。
- Silva JP et al. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature 462:646-50 (2009). IHC-FoFr ; Mouse . PubMed: 19956259