AB41917

Anti-Nurr1 抗体 [N1404]

Name: Anti-Nurr1 抗体 [N1404] (ab41917) | Abcam
Brand: Abcam Limited
SKU: AB41917
Price: 49000 JPY
Availability: InStock
Rating: 4 (9 reviews)

Anti-Nurr1 antibody [N1404]

(9 Reviews)

(31 Publications)

Mouse Monoclonal Nurr1 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 31 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NR4A2 aa 1-100.

別名を表示する

NOT, NURR1, TINUR, NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody [N1404] (AB41917)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody [N1404] (AB41917)

ab41917 staining Nurr1 rat cerebral nerve cell paraffin section (10 ug/mL) by immunohistochemistry, formalin-fixed paraffin embedded sections.

This image was generated using the ascites version of the product.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

N1404

アイソタイプ

IgG2a

キャリアフリー

交差種

Rat

アプリケーション

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human NR4A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P43354

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

style

left-column

製品の詳細

This product was changed from ascites to tissue culture supernatant on 3^rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7 Preservative: 0.1% Sodium azide

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Nuclear receptor-related 1 protein (Nurr1) is a transcription factor weighing approximately 66 kDa. Scientists also know Nurr1 as NR4A2 and it belongs to the NR4A nuclear receptor family. Nurr1 is mainly expressed in the central nervous system where it plays a significant role in neuronal development and maintenance. Despite lacking a defined ligand-binding activity Nurr1 regulates gene expression directly by binding to DNA.

Biological function summary

Nurr1 functions as a critical regulator of dopaminergic neurons in the brain. It is vital for the survival and differentiation of these neurons which are important for motor control and behavioral responses. Nurr1 partners with other transcription factors often functioning in complexes that modulate brain-derived neurotrophic factor (BDNF) signaling. It influences the transcription of genes involved in inflammatory responses and neuroprotection reflecting its importance in maintaining neural health.

Pathways

Nurr1 integrates into key biological processes involving dopaminergic signaling and neuroinflammation. Nurr1 directly participates in the Wnt signaling pathway which plays a role in neuronal development and synaptic function. It also interacts with proteins such as Pitx3 and LMX1B within these pathways contributing to the regulation of dopaminergic neuron function and survival ultimately affecting broader central nervous system activity.

Nurr1 has strong associations with neurological conditions such as Parkinson’s disease and schizophrenia. Its impaired function or altered expression can lead to dopaminergic neuron degeneration a hallmark of Parkinson's disease. Research indicates Nurr1's interaction with parkin a protein implicated in the disease's pathology further emphasizes its importance. In schizophrenia altered Nurr1 activity affects synaptic regulation and cognitive function potentially relating to disrupted dopaminergic and BDNF pathways.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed : 15716272, PubMed : 17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

See full target information NR4A2

style

left-column

文献 (31)

Recent publications for all applications. Explore the full list and refine your search

Neuroscience bulletin : PubMed40921971

2025

Nr4a2, A Key Factor Controlling the Development and Functional Maintenance of Forebrain Car3 Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Chao Tao,Li Zhao,Qiong Zhang,Xi-Yue Liu,Wei-Tang Liu,Ze-Xuan Li,Ling Hu,Lei Zhang,Jia-Yin Chen,Yu-Qiang Ding,Ning-Ning Song

Cell death discovery 11:126 PubMed40164579

2025

Satb2 and Nr4a2 are required for the differentiation of cortical layer 6b.

Applications

Unspecified application

Species

Unspecified reactive species

Li Zhao,Yun-Chao Tao,Ling Hu,Xi-Yue Liu,Qiong Zhang,Lei Zhang,Yu-Qiang Ding,Ning-Ning Song

Cell reports methods 4:100845 PubMed39236715

2024

3D model for human glia conversion into subtype-specific neurons, including dopamine neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Jessica Giacomoni,Andreas Bruzelius,Mette Habekost,Janko Kajtez,Daniella Rylander Ottosson,Alessandro Fiorenzano,Petter Storm,Malin Parmar

Molecular neurobiology 60:7222-7237 PubMed37542647

2023

Anti-inflammatory Effects of Siponimod in a Mouse Model of Excitotoxicity-Induced Retinal Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Devaraj Basavarajappa,Vivek Gupta,Nitin Chitranshi,Deepa Viswanathan,Veer Gupta,Roshana Vander Wall,Viswanthram Palanivel,Mehdi Mirzaei,Yuyi You,Alexander Klistorner,Stuart L Graham

Proceedings of the National Academy of Sciences of the United States of America 120:e2220918120 PubMed37406098

2023

Origin and development of the claustrum in rhesus macaque.

Applications

Unspecified application

Species

Unspecified reactive species

Hong Li,Alvaro Duque,Pasko Rakic

Neural regeneration research 18:2037-2046 PubMed36926730

2023

Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson's disease associated with nuclear receptor-related factor 1 defect.

Applications

Unspecified application

Species

Unspecified reactive species

Piniel Alphayo Kambey,Wen-Ya Liu,Jiao Wu,Bakwatanisa Bosco,Iqra Nadeem,Kouminin Kanwore,Dian-Shuai Gao

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:4594-4604 PubMed35501151

2022

CREB Inactivation by HDAC1/PP1γ Contributes to Dopaminergic Neurodegeneration in Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyi Xu,Xin He,Zeyan Zhang,Yanyi Chen,Junyu Li,Shanshan Ma,Qiaoying Huang,Mingtao Li

Cancer research communications 1:65-78 PubMed35582016

2022

Nuclear Receptor 4A2 (NR4A2/NURR1) Regulates Autophagy and Chemoresistance in Pancreatic Ductal Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mehrdad Zarei,Rupesh Shrestha,Sneha Johnson,Zuhua Yu,Keshav Karki,Ali Vaziri-Gohar,Jessica Epps,Heng Du,Larry Suva,Mahsa Zarei,Stephen Safe

Oxidative medicine and cellular longevity 2022:4054938 PubMed35140838

2022

BMS-470539 Attenuates Oxidative Stress and Neuronal Apoptosis via MC1R/cAMP/PKA/Nurr1 Signaling Pathway in a Neonatal Hypoxic-Ischemic Rat Model.

Applications

Unspecified application

Species

Unspecified reactive species

Shufeng Yu,Desislava Met Doycheva,Marcin Gamdzyk,Yuanyuan Gao,Yong Guo,Zackary D Travis,Jiping Tang,Wen-Xiong Chen,John H Zhang

Frontiers in cellular neuroscience 15:803272 PubMed35087379

2022

Synergistic Effects of Combined Nurr1 Overexpression and Natural Inducers on the More Efficient Production of Dopaminergic Neuron-Like Cells From Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Reyhaneh Beiki,Mahsa Khaghani,Fariba Esmaeili,Fariba Dehghanian

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nurr1 抗体 [N1404]

Anti-Nurr1 antibody [N1404]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody [N1404] (AB41917)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (31)

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise