Anti-Nurr1 抗体 (ab176184)
Key features and details
- Rabbit polyclonal to Nurr1
- Suitable for: WB, IHC-P
- Reacts with: Mouse
- Isotype: IgG
製品の概要
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製品名
Anti-Nurr1 antibody
Nurr1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Nurr1 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Mouse -
免疫原
Synthetic peptide within Human Nurr1 aa 566-591. The exact sequence is proprietary. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker.
Sequence:CTQGLQRIFYLKLEDLVPPPAIIDKL
Database link: P43354 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.02% Sodium azide -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab176184の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 67 kDa).
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| IHC-P |
1/50 - 1/100.
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| 特記事項 |
|---|
|
WB
1/500. Detects a band of approximately 75 kDa (predicted molecular weight: 67 kDa). |
|
IHC-P
1/50 - 1/100. |
ターゲット情報
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機能
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. -
組織特異性
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. -
配列類似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
発生段階
Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 18227 Mouse
- SwissProt: Q06219 Mouse
- Unigene: 3507 Mouse
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別名
- HZF 3 antibody
- HZF3 antibody
- Immediate-early response protein NOT antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)
Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1:50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.
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Western blot - Anti-Nurr1 antibody (ab176184)All lanes : Anti-Nurr1 antibody (ab176184) at 1/500 dilution
Lane 1 : Mouse skeletal muscle tissue lysate
Lane 2 : Mouse heart tissue lysate
Lane 3 : Mouse liver tissue lysate
Lane 4 : Mouse kidney tissue lysate
Lane 5 : Mouse lung tissue lysate
Lane 6 : Mouse large intestine tissue lysate
Lane 7 : Mouse small intestine tissue lysate
Lane 8 : Mouse spleen tissue lysate
Lane 9 : Mouse ovary tissue lysate
Lane 10 : Mouse bladder tissue lysate
Lane 11 : Mouse cerebellum tissue lysate
Lane 12 : Mouse spinal cord tissue lysate
Lane 13 : Mouse brain tissue lysate
Predicted band size: 67 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nurr1 antibody (ab176184)Formalin-fixed, paraffin-embedded mouse kidney tissue stained for Nurr1 using ab176184 at 1:50 dilution (IHC Blocking Buffer) in immunohistochemical analysis. Hematoxylin QS (blue) was used to cunterstain.
データシートおよび資料
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Datasheet download
参考文献 (2)
ab176184 は 2 報の論文で使用されています。
- Liu J et al. The Pathology of Morphine-Inhibited Nerve Repair and Morphine-Induced Nerve Damage Is Mediated via Endoplasmic Reticulum Stress. Front Neurosci 15:618190 (2021). PubMed: 33679302
- Hu L et al. Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-?B pathway. J Neuroinflammation 18:68 (2021). PubMed: 33750404
