Anti-Nurr1 抗体 [447C2a] (ab54366)
![Western blot - Anti-Nurr1 antibody [447C2a] (ab54366)](https://www.abcam.co.jp/ps/products/54/ab54366/Images/ab54366.gif "Western blot - Anti-Nurr1 antibody [447C2a] (ab54366)")
Key features and details
- Mouse monoclonal [447C2a] to Nurr1
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG1
製品の概要
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製品名
Anti-Nurr1 antibody [447C2a]
Nurr1 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [447C2a] to Nurr1 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Recombinant fragment -
免疫原
Nurr1 recombinant fragment (Human)
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 0.03% Potassium phosphate, 0.812% Sodium chloride, 0.1312% Sodium phosphate, 0.0225% Potassium chloride, 1% BSA, PBS -
Concentration information loading... -
精製度
Protein G purified -
特記事項（精製）
ab54366 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG depleted (approximately 95%) fetal bovine serum and filtered through a 0.22µm membrane. -
ポリ/モノ
モノクローナル -
クローン名
447C2a -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab54366の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Detects a band of approximately 37 kDa (predicted molecular weight: 66 kDa).
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| 特記事項 |
|---|
|
WB
Use at an assay dependent concentration. Detects a band of approximately 37 kDa (predicted molecular weight: 66 kDa). |
ターゲット情報
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機能
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. -
組織特異性
Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. -
配列類似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
発生段階
Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of the cell cycle. -
細胞内局在
Nucleus. - Information by UniProt
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別名
- HZF 3 antibody
- HZF3 antibody
- Immediate-early response protein NOT antibody
see all
画像
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Western blot - Anti-Nurr1 antibody [447C2a] (ab54366)Anti-Nurr1 antibody [447C2a] (ab54366) + immunised recombinant protein
Predicted band size: 66 kDa
Observed band size: 37 kDa why is the actual band size different from the predicted?
データシートおよび資料
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Datasheet download
参考文献 (2)
ab54366 は 2 報の論文で使用されています。
- Yao L et al. IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis. J Clin Transl Hepatol 11:787-799 (2023). PubMed: 37408817
- Xu Y et al. Decreased expression levels of Nurr1 are associated with chronic inflammation in patients with type 2 diabetes. Mol Med Rep 12:5487-93 (2015). PubMed: 26239742
