Anti-NUR77 抗体 (ab153914)
Key features and details
- Rabbit polyclonal to NUR77
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-NUR77 antibody
NUR77 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to NUR77 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: ICC/IF -
種交差性
交差種: Mouse, Human
交差が予測される動物種: Rat, Cow, Dog
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免疫原
Recombinant fragment, corresponding to a region within amino acids 361-589 of Human NUR77 (UniProt ID: P22736).
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ポジティブ･コントロール
- 293T and mouse liver lysates; HeLa cells.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab153914の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 64 kDa.
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| 特記事項 |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 64 kDa. |
追加情報
Is unsuitable for ICC/IF.
ターゲット情報
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機能
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. -
組織特異性
Fetal muscle and adult liver, brain and thyroid. -
配列類似性
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 403897 Dog
- Entrez Gene: 3164 Human
- Entrez Gene: 15370 Mouse
- Entrez Gene: 79240 Rat
- Omim: 139139 Human
- SwissProt: P51666 Dog
- SwissProt: P22736 Human
- SwissProt: P12813 Mouse
see all -
別名
- Early response protein NAK1 antibody
- GFRP 1 antibody
- GFRP antibody
see all
画像
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Western blot - Anti-NUR77 antibody (ab153914)All lanes : Anti-NUR77 antibody (ab153914) at 1/500 dilution
Lane 1 : Non-transfected 293T cell lysate
Lane 2 : NR4A1-transfected 293T cell lysate
Predicted band size: 64 kDa
12% SDS PAGE -
Western blot - Anti-NUR77 antibody (ab153914)Anti-NUR77 antibody (ab153914) at 1/1000 dilution + mouse liver whole cell lysate
at 50 µg
Predicted band size: 64 kDa
7.5% SDS PAGE
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab153914 は 5 報の論文で使用されています。
- Schäffner I et al. Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1. Mol Psychiatry 28:497-514 (2023). PubMed: 35318461
- Sheng M et al. Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver. Cell Death Discov 9:106 (2023). PubMed: 36977670
- Chen L et al. Emodin promotes hepatic stellate cell senescence and alleviates liver fibrosis via a nuclear receptor (Nur77)-mediated epigenetic regulation of glutaminase 1. Br J Pharmacol 180:2577-2598 (2023). PubMed: 37263753
- Yuan R et al. Nur77 Deficiency Exacerbates Macrophage NLRP3 Inflammasome-Mediated Inflammation and Accelerates Atherosclerosis. Oxid Med Cell Longev 2022:2017815 (2022). PubMed: 35464766
- Shi W et al. NR4A1 silencing protects against renal ischemia-reperfusion injury through activation of the ß-catenin signaling pathway in old mice. Exp Mol Pathol 111:104303 (2019). PubMed: 31465766