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AB137193

Anti-NRL 抗体

Anti-NRL antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal NRL antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NRL.

別名を表示する

D14S46E, NRL, Neural retina-specific leucine zipper protein

1 Images
Western blot - Anti-NRL antibody (AB137193)
  • WB

Unknown

Western blot - Anti-NRL antibody (AB137193)

All lanes:

Western blot - Anti-NRL antibody (ab137193) at 1/500 dilution

All lanes:

HUVEC cell lysate at 30 µg

Predicted band size: 26 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human NRL. The exact immunogen used to generate this antibody is proprietary information.

P54845

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500.00000 - 1/1000.00000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NRL also known as Neural Retina Leucine zipper is a transcription factor weighing approximately 27 kDa. It plays a mechanical role in the regulation of gene expression specific to the retina. Predominantly expressed in the photoreceptor cells of the retina NRL is important for the development and maintenance of these cells. Its expression is tightly controlled during retinal differentiation particularly in rod photoreceptors where it dictates cellular development.
Biological function summary

NRL acts as an important regulator in photoreceptor cell differentiation and function. It forms complexes with other transcription factors such as CRX and NR2E3 to activate transcription of rod-specific genes. These complexes are important for the expression of genes necessary for phototransduction the process by which light is converted into electrical signals in the eyes. NRL's interactions target important retinal genes establishing its role as a determinant for rod versus cone cell fates.

Pathways

The activity of NRL is integrated into the phototransduction and retinoid metabolism pathways. Within these pathways NRL cooperates with other proteins like CRX and NR2E3 to control the expression of genes needed for rod photoreceptor function. NRL's orchestration of gene expression in these pathways assures the successful transduction of light signals and vitamin A recycling which are reactions critical for vision.

Mutations or dysfunctions in NRL are connected to retinal degenerative diseases like retinitis pigmentosa and Leber congenital amaurosis. In these conditions NRL's aberrant activity disrupts proper photoreceptor development leading to visual impairment. NRL's interactions with proteins such as CRX in these diseases are pivotal as mutations affecting these proteins also contribute to the pathogenesis highlighting the tight regulation required for correct retinal function.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed : 21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed : 17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed : 17335001).
See full target information NRL
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Genetics in medicine : official journal of the American College of Medical Genetics 21:694-704 PubMed30072743

2018

Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Farzad Jamshidi,Emily M Place,Sudeep Mehrotra,Daniel Navarro-Gomez,Mathew Maher,Kari E Branham,Elise Valkanas,Timothy J Cherry,Monkol Lek,Daniel MacArthur,Eric A Pierce,Kinga M Bujakowska
View all publications
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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