AB216413

Anti-Nociceptin 抗体

Name: Anti-Nociceptin 抗体 (ab216413) | Abcam
Brand: Abcam Limited
SKU: AB216413
Price: 75000 JPY
Availability: InStock

Anti-Nociceptin antibody

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(3 Publications)

Rabbit Polyclonal Nociceptin antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PNOC aa 100-150 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

OFQ, PNOC, Prepronociceptin

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nociceptin antibody (AB216413)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nociceptin antibody (AB216413)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Nociceptin with ab216413 at 1/300 dilution, followed by conjugation to the secondary antibody and DAB staining.

Supplier Data

Western blot - Anti-Nociceptin antibody (AB216413)

15% gel.

All lanes:

Western blot - Anti-Nociceptin antibody (ab216413) at 1/200 dilution

Lane 1:

rat brain lysate

Lane 2:

rat liver lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/3000 dilution

Predicted band size: 20 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat

アプリケーション

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human PNOC aa 100-150 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q13519

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/100 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Nociceptin also known as Orphanin FQ is a neuropeptide that functions as a ligand for the nociceptin receptor (NOP receptor or ORL1). It is a peptide made of 17 amino acids with an approximate mass of 2 kDa. Nociceptin is widely expressed in the central and peripheral nervous systems including the brain spinal cord and peripheral sensory neurons. It is involved in modulating various physiological processes through interaction with its receptor influencing neuronal excitability and synaptic plasticity.

Biological function summary

Nociceptin impacts pain modulation stress response and behavioral regulation. It forms a signaling complex with the NOP receptor which is a member of the opioid receptor family. Unlike classical opioid peptides nociceptin does not bind to opioid receptors (mu delta or kappa) and is considered to have a distinct role in the nervous system. Its action can be anti-opioid or analgesic depending on the context of its expression and the physiological state influenced.

Pathways

Nociceptin plays a significant role in nociceptive pathways and stress-related pathways. In the nociceptive pathways it regulates pain transmission through its interaction with the NOP receptor which can inhibit neurotransmitter release and hyperalgesia. Related proteins in these pathways include neurotransmitters like substance P and calcitonin gene-related peptide (CGRP). In stress-related pathways nociceptin interacts with components involved in the hypothalamic-pituitary-adrenal (HPA) axis modulating stress hormone release and affecting behavioral responses to stress.

Nociceptin has been linked to chronic pain conditions and anxiety disorders. Its dysregulation can contribute to altered pain perception seen in chronic pain syndromes with connections to proteins like cyclooxygenase (COX) in the peripheral inflammation response. In anxiety disorders nociceptin's influence on behavioral responses to stress relates to pathways involving corticotropin-releasing factor (CRF) which also interacts with the HPA axis. By understanding these connections researchers aim to explore nociceptin as a potential therapeutic target for these disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Nociceptin. Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.. Nocistatin. Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.. Orphanin FQ2. Has potent analgesic activity.

See full target information PNOC

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Foods (Basel, Switzerland) 13: PubMed39200401

2024

Ex Vivo Study of Colon Health, Contractility and Innervation in Male and Female Rats after Regular Exposure to Instant Cascara Beverage.

Applications

Unspecified application

Species

Unspecified reactive species

Paula Gallego-Barceló,David Benítez-Álvarez,Ana Bagues,Blanca Silván-Ros,Alba Montalbán-Rodríguez,Laura López-Gómez,Gema Vera,María Dolores Del Castillo,José A Uranga,Raquel Abalo

Translational neuroscience 12:523-532 PubMed34963819

2021

Neuropeptide changes in an improved migraine model with repeat stimulations.

Applications

Unspecified application

Species

Unspecified reactive species

Yichen Guo,Yawen Cheng,Jiaqi An,Yi Qi,Guogang Luo

BMC neuroscience 22:25 PubMed33836649

2021

N/OFQ modulates orofacial pain induced by tooth movement through CGRP-dependent pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyu Yan,Han Han,Shizhen Zhang,Yanzhu Lu,Linghuan Ren,Yufei Tang,Xiaolong Li,Fan Jian,Yan Wang,Hu Long,Wenli Lai

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nociceptin 抗体

Anti-Nociceptin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Nociceptin antibody (AB216413)

Western blot - Anti-Nociceptin antibody (AB216413)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

Abcam product promise