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AB71904

Anti-NMNAT3 抗体

Anti-NMNAT3 antibody

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(3 Publications)

Mouse Polyclonal NMNAT3 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NMNAT3.

別名を表示する

FKSG76, NMNAT3, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3, NMN/NaMN adenylyltransferase 3, Nicotinamide-nucleotide adenylyltransferase 3, Nicotinate-nucleotide adenylyltransferase 3, Pyridine nucleotide adenylyltransferase 3, NMN adenylyltransferase 3, NaMN adenylyltransferase 3, PNAT-3

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

Yes

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human NMNAT3.

Q96T66

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代替製品

Primary Antibodies

AB121030

Anti-NMNAT3 antibody

Western blot - Anti-NMNAT3 antibody (AB121030)

  • 0
  • 0
Primary Antibodies

AB230839

Anti-NMNAT3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMNAT3 antibody (AB230839)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB56980

Anti-NMNAT2 antibody [2E4]

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-NMNAT2 antibody [2E4] (AB56980)

  • 4
  • 1
Primary Antibodies

AB118270

Anti-Nmnat1/NMNAT antibody [OTI1F7]

Immunocytochemistry/ Immunofluorescence - Anti-Nmnat1/NMNAT antibody [OTI1F7] (AB118270)

  • 0
  • 0
Primary Antibodies

AB189494

Anti-SIRT1 antibody [EPR18239]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SIRT1 antibody [EPR18239] (AB189494)

  • 4
  • 4
Primary Antibodies

AB236874

Anti-Visfatin antibody [EPR21980]

RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Visfatin antibody [EPR21980] (AB236874)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NMNAT3 or nicotinamide nucleotide adenylyltransferase 3 catalyzes the biosynthesis of NAD+ from NMN and ATP playing a role in cellular energy metabolism. Alternate names include NMNAT3p and Enzyme NIC. It has a molecular mass of around 31 kDa. NMNAT3 is expressed in a variety of tissues with significant expression in red blood cells and the mitochondria of other cell types.
Biological function summary

NMNAT3 participates in the NAD+ salvage pathway transforming NMN into NAD+ a fundamental coenzyme in cellular metabolism and redox reactions. It does not form part of any larger complex but functions independently within the cell. Its activity supports energy production DNA repair and cell signaling processes making it an important player in maintaining cellular homeostasis.

Pathways

The salvage pathway for NAD+ biosynthesis relies heavily on NMNAT3's enzymatic action. It works alongside related proteins like NMNAT1 and NMNAT2 which catalyze similar reactions in different cellular locations. This pathway intersects with the oxidative phosphorylation process a critical energy-producing pathway within mitochondria.

NMNAT3 has implications in conditions such as anemia and mitochondrial dysfunction. Altered expression or mutation of NMNAT3 may contribute to anemia by affecting red blood cell metabolism and NAD+ homeostasis. The protein also relates to neurodegenerative disorders due to its role in mitochondrial function and energy balance aligning with proteins like Sirtuins which also regulate NAD+ levels and have implications in cellular aging processes.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed : 16118205, PubMed : 17402747, PubMed : 26616331). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury (PubMed : 16118205, PubMed : 17402747). May be involved in the maintenance of axonal integrity (By similarity). Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity (PubMed : 18344983).
See full target information NMNAT3
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eadr8648 PubMed40106551

2025

PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoliang Fang,Yi Zhong,Rui Zheng,Qihui Wu,Yu Liu,Dexin Zhang,Yuwei Wang,Wubing Ding,Kaiyuan Wang,Fengbo Zhong,Kai Lin,Xiaohui Yao,Qingxun Hu,Xiaofei Li,Guofeng Xu,Na Liu,Jing Nie,Dali Li,Hongquan Geng,Yuting Guan

Human molecular genetics 31:2918-2933 PubMed35397003

2022

Alpha-synucleinopathy reduces NMNAT3 protein levels and neurite formation that can be rescued by targeting the NAD+ pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Richard B Parsons,Altin Kocinaj,Gustavo Ruiz Pulido,Sarah A Prendergast,Anna E Parsons,Paul D Facey,Frank Hirth

Frontiers in aging neuroscience 14:852972 PubMed35401143

2022

Human Nmnat1 Promotes Autophagic Clearance of Amyloid Plaques in a Model of Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Zhu,Amanda G Lobato,R Grace Zhai,Milena Pinto
View all publications
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