Anti-NMDAR2A 抗体 (ab169873)
Key features and details
- Rabbit polyclonal to NMDAR2A
- Suitable for: WB, IHC-P, IP
- Reacts with: Mouse, Rat, Rabbit, Human
- Isotype: IgG
製品の概要
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製品名
Anti-NMDAR2A antibody
NMDAR2A 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to NMDAR2A -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-P, IPmore details -
種交差性
交差種: Mouse, Rat, Rabbit, Human -
免疫原
Fusion protein corresponding to Rat NMDAR2A (C terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.50
Constituents: 0.24% HEPES, 0.88% Sodium chloride, 0.01% BSA, 50% Glycerol -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab169873 is prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab169873の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000. Predicted molecular weight: 165 kDa.
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| IHC-P |
1/1000.
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| IP |
Use at an assay dependent concentration.
Recommended dilution: 6 ul per 200 ug lysate. |
| 特記事項 |
|---|
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WB
1/1000. Predicted molecular weight: 165 kDa. |
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IHC-P
1/1000. |
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IP
Use at an assay dependent concentration. Recommended dilution: 6 ul per 200 ug lysate. |
ターゲット情報
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機能
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. -
配列類似性
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2A/GRIN2A subfamily. -
細胞内局在
Cell membrane. Cell junction > synapse > postsynaptic cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2903 Human
- Entrez Gene: 14811 Mouse
- Entrez Gene: 24409 Rat
- Omim: 138253 Human
- SwissProt: Q12879 Human
- SwissProt: P35436 Mouse
- SwissProt: Q00959 Rat
- Unigene: 411472 Human
see all -
別名
- EPND antibody
- FESD antibody
- GluN2A antibody
see all
画像
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Western blot - Anti-NMDAR2A antibody (ab169873)Anti-NMDAR2A antibody (ab169873) at 1/1000 dilution + Rat hippocampal lysate at 10 µg
Predicted band size: 165 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NMDAR2A antibody (ab169873)Immunohistochemical analysis of rabbit retina tissue labeling NMDAR2A with ab169873 at 1/1000 dilution.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab169873 は 9 報の論文で使用されています。
- Dyomina AV et al. MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy. Int J Mol Sci 23:N/A (2022). PubMed: 35008924
- Postnikova TY et al. Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats. Int J Mol Sci 23:N/A (2022). PubMed: 36362260
- Powell GL et al. Chronic treatment with N-acetylcysteine decreases extinction responding and reduces cue-induced nicotine-seeking. Physiol Rep 7:e13958 (2019). PubMed: 30632301
- Davis-Reyes BD et al. Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats. Biochem Pharmacol 168:204-213 (2019). PubMed: 31295463
- Kaneko Y et al. Pituitary Adenylate Cyclase Activating Polypeptide Elicits Neuroprotection Against Acute Ischemic Neuronal Cell Death Associated with NMDA Receptors. Cell Physiol Biochem 51:1982-1995 (2018). PubMed: 30513524
- Tang Y et al. Pre-existing weakness is critical for the occurrence of postoperative cognitive dysfunction in mice of the same age. PLoS One 12:e0182471 (2017). PubMed: 28787017
- Zhang S et al. Sepsis-induced selective loss of NMDA receptors modulates hippocampal neuropathology in surviving septic mice. PLoS One 12:e0188273 (2017). PubMed: 29176858
- Tucsek Z et al. Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. Geroscience N/A:N/A (2017). WB . PubMed: 28664509
- Roy A et al. Identification and characterization of PPARa ligands in the hippocampus. Nat Chem Biol 12:1075-1083 (2016). PubMed: 27748752