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AB269711

Anti-Neurotensin Receptor 1/NTSR1 抗体 [B-N6] - BSA and Azide free

Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] - BSA and Azide free

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(1 Publication)

Mouse Monoclonal Neurotensin Receptor 1/NTSR1 antibody. Carrier free. Suitable for Flow Cyt and reacts with Transfected cell line - Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing NTSR1 protein.

別名を表示する

NTRR, NTSR1, Neurotensin receptor type 1, NT-R-1, NTR1, High-affinity levocabastine-insensitive neurotensin receptor, NTRH

1 Images
Flow Cytometry - Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] - BSA and Azide free (AB269711)
  • Flow Cyt

Unknown

Flow Cytometry - Anti-Neurotensin Receptor 1/NTSR1 antibody [B-N6] - BSA and Azide free (AB269711)

Staining pattern of NTR transfected CHO cell line with ab27380.This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (ab27380)

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

B-N6

アイソタイプ

IgM

軽鎖のタイプ

kappa

キャリアフリー

Yes

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing NTSR1 protein. The exact immunogen used to generate this antibody is proprietary information.

P30989

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Transfected cell line - Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p>" } } }
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製品の詳細

ab269711 is a carrier free version of ab27380.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

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出荷温度及び保存条件

製品の状態
Liquid
精製に関する特記事項
Gel filtration
バッファー組成
pH: 7.3 - 7.5 Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
+4°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Neurotensin Receptor 1 also known as NTSR1 functions as a G-protein coupled receptor (GPCR) that binds to the neuropeptide neurotensin. This protein consists of seven transmembrane domains typical of GPCRs and has a molecular mass of roughly 46 kDa. NTSR1 commonly expresses in the central nervous system particularly in the brain regions such as hypothalamus and basal ganglia and also in peripheral tissues like the gastrointestinal tract.
Biological function summary

NTSR1 influences signaling cascades that regulate various physiological processes. It forms part of a receptor-ligand complex with neurotensin a peptide that modulates neurotransmission and hormone regulation. Neurotensin and NTSR1 interaction can affect neurotransmitter release modulating pathways related to pain locomotion and thermoregulation. Researchers have observed significant roles of the receptor in neural proliferation as well.

Pathways

NTSR1 acts significantly in the dopaminergic and phosphatidylinositol signaling pathways. In the dopaminergic system NTSR1 interacts with dopamine D2 receptors influencing dopamine-mediated behaviors and responses. In phosphatidylinositol signaling it regulates downstream effectors like protein kinase C impacting cellular responses. These pathways integrate NTSR1 into broader signaling networks that control critical neuronal functions and responses.

NTSR1 has connections to certain neurological and psychiatric disorders such as schizophrenia and Parkinson's disease. Abnormal NTSR1 signaling affects dopaminergic neurotransmission which highlights its role in these conditions. Altered interactions with proteins like the dopamine D2 receptor contribute to the pathological symptoms observed in these diseases. Research into NTSR1 and its pathways may reveal targets for therapeutic intervention.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed : 21725197, PubMed : 23140271, PubMed : 8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (PubMed : 21725197).
See full target information NTSR1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 13:4663 PubMed36949141

2023

NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein.

Applications

Unspecified application

Species

Unspecified reactive species

Fotine Libanje,Raphael Delille,Pamela A Young,Sylvie Rolland,Florence Meyer-Losic,Elodie Lewkowicz,Stephan Klinz
View all publications
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代替製品

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