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AB221456

Anti-Netrin G1 抗体

Anti-Netrin G1 antibody

1

(1 Review)

|

(2 Publications)

Rabbit Polyclonal Netrin G1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NTNG1 aa 1-100.

別名を表示する

KIAA0976, LMNT1, UNQ571/PRO1133, NTNG1, Netrin-G1, Laminet-1

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-Netrin G1 antibody (AB221456)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Netrin G1 antibody (AB221456)

Immunofluorescent analysis of paraformaldehyde-fixed, Triton X-100 permeabilized BJ cells labeling Netrin G1 with ab221456 at 4 μg/mL dilution (green).

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human NTNG1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2I2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Netrin G1 also known as Netrin-G1 or NTNG1 is a protein involved in axonal guidance. This protein helps in the development and differentiation of the central nervous system. It has a mass of approximately 64 kDa. Netrin G1 is expressed in brain regions such as the hippocampus and cerebral cortex. Unlike other netrins it is tethered to the membrane through a glycosylphosphatidylinositol (GPI) anchor affecting its signaling properties.
Biological function summary

Netrin G1 plays a significant role in neuronal circuit formation. It interacts with ligands like NGL1 and NGL2 to mediate cell signaling pathways that guide axonal growth and synapse formation. While it is not a part of a molecular complex on its own its association with these partners enhances its functionality in synaptic connectivity and neural network maintenance.

Pathways

Netrin G1 engages in the axon guidance pathway and is involved in nervous system development processes. It works alongside proteins such as Netrin-1 to influence the direction and growth of axons. Through these interactions Netrin G1 contributes to the precise wiring of the nervous system required for proper function. Understanding its role in these pathways provides insight into the molecular mechanisms of neural development.

Changes in Netrin G1 expression and function have been linked to neuropsychiatric conditions like schizophrenia and autism spectrum disorders. Studies suggest that Netrin G1 through its interaction with other proteins like Netrin-1 and DCC can alter synaptic connectivity which may play a role in the pathology of these conditions. These associations make Netrin G1 a potential target for therapeutic interventions in related neurological disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
See full target information NTNG1
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature neuroscience 28:1146-1159 PubMed40442499

2025

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Li,Khomgrit Morarach,Ziwei Liu,Sanghita Banerjee,Yanan Chen,Ashley L Harb,Joel M Kosareff,Charles R Hall,Fernando López-Redondo,Elham Jalalvand,Suad H Mohamed,Anastassia Mikhailova,David R Linden,Ulrika Marklund

Protein & cell 12:557-577 PubMed32683582

2020

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Kun Xia,Yi-Rong Zeng,Meng-Li Zhang,Peng Liu,Fang Liu,Hao Zhang,Chen-Xi He,Yi-Ping Sun,Jin-Ye Zhang,Cheng Zhang,Lei Song,Chen Ding,Yu-Jie Tang,Zhen Yang,Chen Yang,Pu Wang,Kun-Liang Guan,Yue Xiong,Dan Ye
View all publications
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