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AB109288

Anti-NETO2 抗体 [EPR3497]

Anti-NETO2 antibody [EPR3497]

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(6 Publications)

Rabbit Recombinant Monoclonal NETO2 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 6 publications.

別名を表示する

BTCL2, UNQ1926/PRO4401, NETO2, Neuropilin and tolloid-like protein 2, Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2

2 Images
Western blot - Anti-NETO2 antibody [EPR3497] (AB109288)
  • WB

Unknown

Western blot - Anti-NETO2 antibody [EPR3497] (AB109288)

All lanes:

Western blot - Anti-NETO2 antibody [EPR3497] (ab109288) at 1/1000 dilution

Lane 1:

mouse brain lysates at 10 µg

Lane 2:

rat brain lysates at 10 µg

Predicted band size: 101 kDa,118 kDa,140 kDa,15 kDa,45 kDa,51 kDa,56 kDa,59 kDa,63 kDa,92 kDa

Observed band size: 101 kDa,110 kDa,140 kDa,15 kDa,49 kDa,56 kDa,92 kDa

false

Western blot - Anti-NETO2 antibody [EPR3497] (AB109288)
  • WB

Unknown

Western blot - Anti-NETO2 antibody [EPR3497] (AB109288)

All lanes:

Western blot - Anti-NETO2 antibody [EPR3497] (ab109288) at 1/1000 dilution

Lane 1:

Human cerebellum lysates at 10 µg

Lane 2:

SH-SY5Y cell lysates at 10 µg

Lane 3:

Human brain lysates at 10 µg

Predicted band size: 59 kDa

false

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-NETO2 antibody [EPR3497] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR3497

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat, Human

アプリケーション

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.31% Sodium citrate, 0.175% Sodium chloride, 0.05% BSA, 0.0172% Ethylenediaminetetraacetic acid, disodium, dihydrate
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NETO2 also known as Neuropilin and Tolloid-Like 2 is a transmembrane protein with a known mass of approximately 58 kDa. This protein functions mechanically as an auxiliary subunit for kainate receptors in the central nervous system. Researchers observe its expression predominantly in neurons but also in some other tissues. NETO2 alongside its variants impacts receptor functionality by modulating properties like receptor trafficking and kinetic attributes.
Biological function summary

The protein affects synaptic plasticity and neuronal communication. NETO2 forms part of a receptor complex with kainate receptors influencing synaptic transmission processes. This association is significant for excitatory neurotransmission which is important for learning and memory. Researchers emphasize the role of NETO2 in maintaining neuronal circuit efficiency and integrity.

Pathways

NETO2 involvement strongly ties to glutamatergic synapse pathways. It influences neuronal signaling through kainate receptor modulation which in turn affects calcium ion permeation. NETO2 also interacts with other proteins like GRIP1 (Glutamate Receptor Interacting Protein 1) within these pathways orchestrating synaptic stability and function.

Researchers link NETO2 alterations mainly to psychiatric disorders such as schizophrenia and neurodevelopmental disorders. In these contexts aberrant interactions with proteins like PSD95 (Postsynaptic Density Protein 95) could disrupt normal synaptic functioning. Researchers continue to investigate how dysregulation in NETO2 contributes to the molecular pathways underlying these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity).
See full target information NETO2
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy oncolytics 24:535-546 PubMed35229031

2022

TTN-AS1 accelerates the growth and migration of nasopharyngeal carcinoma cells via targeting miR-876-5p/NETO2.

Applications

Unspecified application

Species

Unspecified reactive species

Xinping Chen,Weihua Xu,Zhichao Ma,Juan Zhu,Junjie Hu,Xiaojuan Li,Shengmiao Fu

Oncology letters 22:818 PubMed34671432

2021

Long non-coding RNA SNHG17 promotes lung adenocarcinoma progression by targeting the microRNA-193a-5p/NETO2 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiwei Zhang,Yulan Yan,Bin Zhang,Yuchen Ma,Chen Chen,Changli Wang

Cell reports 31:107735 PubMed32521260

2020

Kainate Receptor Activation Shapes Short-Term Synaptic Plasticity by Controlling Receptor Lateral Mobility at Glutamatergic Synapses.

Applications

Unspecified application

Species

Unspecified reactive species

Alice Polenghi,Thierry Nieus,Stefania Guazzi,Pau Gorostiza,Enrica Maria Petrini,Andrea Barberis

The Journal of biological chemistry 292:15369-15377 PubMed28717010

2017

Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1.

Applications

Unspecified application

Species

Unspecified reactive species

Richa Madan Lomash,Nengyin Sheng,Yan Li,Roger A Nicoll,Katherine W Roche

The Journal of neuroscience : the official journal 37:3352-3363 PubMed28235897

2017

Neto2 Assembles with Kainate Receptors in DRG Neurons during Development and Modulates Neurite Outgrowth in Adult Sensory Neurons.

Applications

WB

Species

Unspecified reactive species

Claire G Vernon,Geoffrey T Swanson

BMC cancer 15:1006 PubMed26699544

2015

Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma.

Applications

WB

Species

Human

Liang Hu,Hai-Yang Chen,Jian Cai,Guang-Zhen Yang,Dan Feng,Yan-Xia Zhai,Hui Gong,Chen-Ye Qi,Yu Zhang,Hao Fu,Qing-Ping Cai,Chun-Fang Gao
View all publications
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Abcam product promise

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