JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB200698

Anti-NCAM1 抗体 [123C3.D5 + 123A8]

Anti-NCAM1 antibody [123C3.D5 + 123A8]

1

(1 Review)

|

(4 Publications)

Mouse Multiclonal NCAM1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Cell preparation containing NCAM1 protein.

別名を表示する

CD56, NCAM, NCAM1, Neural cell adhesion molecule 1, N-CAM-1, NCAM-1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [123C3.D5 + 123A8] (AB200698)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [123C3.D5 + 123A8] (AB200698)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human neuro-endocrine tumor tissue labelling NCAM with ab200698.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [123C3.D5 + 123A8] (AB200698)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [123C3.D5 + 123A8] (AB200698)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon ganglion tissue labeling NCAM with ab200698 at 1 μg/ml.

Key facts

宿主種

Mouse

クローン性

Multiclonal

クローン番号

123C3.D5 + 123A8

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Cell preparation containing NCAM1 protein. The exact immunogen used to generate this antibody is proprietary information.

P13591

特異性

ab200698 reacts with an extracellular domain (close to transmembrane) of NCAM.

style
left-column

代替製品

Primary Antibodies

AB237708

Anti-NCAM1 antibody [CAL53]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [CAL53] (AB237708)

  • 5
  • 2
Primary Antibodies

AB237381

PE Anti-NCAM1 antibody [EPR21827]

RabMAb|Recombinant

Flow Cytometry - PE Anti-NCAM1 antibody [EPR21827] (AB237381)

  • 0
  • 0
Primary Antibodies

AB200333

Alexa Fluor® 488 Anti-NCAM1 antibody [EPR2566]

RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Alexa Fluor® 488 Anti-NCAM1 antibody [EPR2566] (AB200333)

  • 0
  • 0
Primary Antibodies

AB137086

Anti-NCAM1 antibody [EP2566(2)]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EP2566(2)] (AB137086)

  • 0
  • 0
Primary Antibodies

AB220360

Anti-NCAM1 antibody [EPR21827]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EPR21827] (AB220360)

  • 4
  • 2
Primary Antibodies

AB75813

Anti-NCAM1 antibody [EP2567Y]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EP2567Y] (AB75813)

  • 4
  • 7
Primary Antibodies

AB215981

Anti-NCAM1 antibody [EP2567Y] - Low endotoxin, Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EP2567Y] - Low endotoxin, Azide free (AB215981)

  • 0
  • 0
Primary Antibodies

AB214436

Anti-NCAM1 antibody [EPR2566] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EPR2566] - BSA and Azide free (AB214436)

  • 4
  • 3
Primary Antibodies

AB237457

PE Anti-NCAM1 antibody [EP2567Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - PE Anti-NCAM1 antibody [EP2567Y] (AB237457)

  • 0
  • 0
Primary Antibodies

AB133345

Anti-NCAM1 antibody [EPR2566]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NCAM1 antibody [EPR2566] (AB133345)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
Primary Antibodies

AB216000

Anti-FOXP3 antibody [EPR15038-69] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP3 antibody [EPR15038-69] - BSA and Azide free (AB216000)

  • 5
  • 1
Primary Antibodies

AB16669

Anti-CD3 epsilon antibody [SP7]

BOND RX™ Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Multiplex immunohistochemistry - Anti-CD3 epsilon antibody [SP7] (AB16669)

  • 4
  • 80
Primary Antibodies

AB215977

Anti-CD16 antibody [EPR16784] - Low endotoxin, Azide free

BOND RX™ Validated|RabMAb|Recombinant

Mass Cytometry - Anti-CD16 antibody [EPR16784] - Low endotoxin, Azide free (AB215977)

  • 4
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p>30 minutes at RT.</p>" } } }
style
left-column

製品の詳細

Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135 kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. ab200698 recognizes two proteins of the NCAM, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). ab200698 ;plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

What is an oligoclonal antibody?
This oligoclonal antibody is a cocktail of monoclonal antibodies that have been carefully selected. Oligoclonal antibodies have not only the specificity and batch-to-batch consistency of a monoclonal antibody, but also have the advantage of the sensitivity of a polyclonal antibody due to their ability to recognize multiple epitopes on an antigen.

style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
精製に関する特記事項
ab200698 was purified from Bioreactor Concentrate.
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NCAM1 also known as Neural Cell Adhesion Molecule 1 or CD56 is an important cell surface glycoprotein that plays a role in cell-cell adhesion. It has a molecular mass of approximately 120-140 kDa. NCAM1 is widely expressed in various tissues including the nervous system skeletal muscle and certain hematopoietic cells. In flow cytometry and immunohistochemistry NCAM1's expression is extensively studied to track and analyze cell populations using techniques like NCAM1 ELISA for quantification.
Biological function summary

NCAM1 influences neuronal growth survival and synaptic plasticity. This protein is part of the immunoglobulin superfamily and contributes to dynamic interactions during development. NCAM1 exists on cell membranes assisting in the formation and maintenance of tissue structures. In particular cell adhesion molecule CAL53 interacts with NCAM1 highlighting its involvement in synaptic connections. Additionally NCAM1 impacts cellular migration and differentiation particularly in myogenic processes involving MY31's pathway.

Pathways

The NCAM1 protein participates in the MAPK signaling pathway and the PI3K/AKT pathway both essential in cellular growth and survival. NCAM1 acts alongside ERIC1 aiding in the transduction of signals that regulate cytoskeletal rearrangement. These pathways influence cellular communication and responses to external stimuli further enhancing tissue development and regeneration mechanisms.

NCAM1 is associated with neurodegenerative conditions like Alzheimer's disease and certain types of cancer including neuroblastoma. Changes in NCAM1 expression or function can disrupt normal cell adhesion and signaling leading to pathological states. The protein's interaction with cell surface markers such as CD56 mouse marker helps in the diagnosis and therapy of these disorders providing potential therapeutic targets or biomarkers for clinical applications.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.. (Microbial infection) Acts as a receptor for rabies virus.. (Microbial infection) Acts as a receptor for Zika virus.
See full target information NCAM1
style
left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:2663 PubMed38302650

2024

Outlining the skin-homing and circulating CLANK cells in patients with severe atopic dermatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Josenilson Feitosa de Lima,Franciane Mouradian Emidio Teixeira,Yasmim Álefe Leuzzi Ramos,Gabriel Costa de Carvalho,Anna Claudia Calvielli Castelo Branco,Naiura Vieira Pereira,Mírian Nacagami Sotto,Valéria Aoki,Maria Notomi Sato,Raquel Leao Orfali

The Journal of clinical investigation 132: PubMed35113815

2022

Lysosomal exocytosis of HSP70 stimulates monocytic BMP6 expression in Sjögren's syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Ying-Qian Mo,Hiroyuki Nakamura,Tsutomu Tanaka,Toshio Odani,Paola Perez,Youngmi Ji,Benjamin N French,Thomas Jf Pranzatelli,Drew G Michael,Hongen Yin,Susan S Chow,Maryam Khalaj,Sandra A Afione,Changyu Zheng,Fabiola Reis Oliveira,Ana Carolina F Motta,Alfredo Ribeiro-Silva,Eduardo M Rocha,Cuong Q Nguyen,Masayuki Noguchi,Tatsuya Atsumi,Blake M Warner,John A Chiorini

Oncology reports 47: PubMed34958112

2021

Systematic characterization of the tumor microenvironment in Chinese patients with hepatocellular carcinoma highlights intratumoral B cells as a potential immunotherapy target.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Feng,Liguo Liu,Jing Li,Jia Huang,Jenny H Xie,Laurence Menard,Yanfen Shi,Xiaohong Zhao,Shan Xie,Wenjuan Zang,Haidong Tan,Zhiying Yang,Ling Ni

Theranostics 9:1029-1046 PubMed30867814

2019

Human parthenogenetic neural stem cell grafts promote multiple regenerative processes in a traumatic brain injury model.

Applications

Unspecified application

Species

Unspecified reactive species

Jea-Young Lee,Sandra Acosta,Julian P Tuazon,Kaya Xu,Hung Nguyen,Trenton Lippert,Michael G Liska,Andrey Semechkin,Ibon Garitaonandia,Rodolfo Gonzalez,Russell Kern,Cesario V Borlongan
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com