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AB66743

Anti-Nav1.8/SCN10A 抗体

Anti-Nav1.8/SCN10A antibody

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(6 Publications)

Rabbit Polyclonal Nav1.8/SCN10A antibody. Suitable for ICC and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human SCN10A.

別名を表示する

Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, PN3, hPN3, SCN10A

1 Images
Immunocytochemistry - Anti-Nav1.8/SCN10A antibody (AB66743)
  • ICC

Supplier Data

Immunocytochemistry - Anti-Nav1.8/SCN10A antibody (AB66743)

ab66743 staining Nav1.8/SCN10A in human sperm cells by Immunocytochemistry/ Immunofluorescence.Sperm cells were washed, re-suspended in phosphate-buffered saline and smeared onto poly-L-lysine-coated slides. Spermatozoa were then fixed by incubation in cold methanol (-20°C) for 20 minutes. Slides were washed three times for 10 minutes with PBS and incubated with 2% BSA in PBS for 30 minutes to block non-specific sites. Test slides were incubated with ab66743 at a 1/100 dilution. Samples were washed three times in PBS, and incubated for 60 minutes with appropriate FITC-conjugated secondary antibodies. Slides were further washed in PBS, mounted using Vectashield and examined with a Olympus BX-51 fluorescence microscopy using a 100× immersion objective.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ICC

applications

免疫原

Synthetic Peptide within Human SCN10A. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5Y9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "1/100 - 1/1000", "ICC-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Constituents: Whole serum
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Nav1.8 also known as SCN10A is a voltage-gated sodium channel. It facilitates the rapid transit of sodium ions across cell membranes essential for the propagation of action potentials in neurons. Nav1.8 has a mass of approximately 220 kDa and it expresses primarily in peripheral sensory neurons including dorsal root ganglia. This channel is activated mainly in response to depolarization enabling the initiation and conduction of electrical signals.
Biological function summary

Nav1.8 contributes significantly to pain transmission especially in nociceptive neurons which detect painful stimuli. It operates as a principal component in generating sustained action potentials required for pain signal propagation. Nav1.8 is not a part of a larger complex but plays a standalone critical role. It shows high expression during inflammatory and neuropathic pain conditions indicating its role in pain pathways.

Pathways

Nav1.8 is involved in both the pain and neuroinflammatory pathways. It influences the activity of other sodium channels such as Nav1.7 another critical mediator of pain sensation. Pain pathways extensively integrate Nav1.8 function especially in the modulation of pain thresholds and states. Neuroinflammatory pathways utilize Nav1.8 to alter neuron excitability under inflammatory conditions which is significant for understanding different pain modalities.

Nav1.8 is associated with chronic pain disorders such as neuropathic pain and inflammatory pain conditions. Variations in Nav1.8 are linked to altered pain sensitivity and are researched as potential therapeutic targets for pain relief. In diseases like diabetic neuropathy Nav1.8 changes correlate with increased neuronal excitability and persistent pain sensation. Its relationship with proteins like Nav1.7 in these contexts highlights its importance in the diagnostic and therapeutic options for pain management.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
See full target information SCN10A
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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Journal of neurochemistry 169:e70004 PubMed39871624

2025

GABA Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell-Derived Sensory Neurons by Baclofen and α-Conotoxin Vc1.1.

Applications

Unspecified application

Species

Unspecified reactive species

Mitchell St Clair-Glover,Arsalan Yousuf,Dominic Kaul,Mirella Dottori,David J Adams

eNeuro 11: PubMed39542733

2024

Procaine Regulates the STAT3/CCL5 Axis and Inhibits Microglia M1 Polarization to Alleviate Complete Freund's Adjuvant Rats Pain Behavior.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Sun,Kai Zhang,Chen Li,QingDong Wang,Rongjia Zang

Frontiers in cellular neuroscience 14:600895 PubMed33362470

2020

Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Amy J Hulme,Jeffrey R McArthur,Simon Maksour,Sara Miellet,Lezanne Ooi,David J Adams,Rocio K Finol-Urdaneta,Mirella Dottori

The journal of headache and pain 15:63 PubMed25261281

2014

Expression of 5-HT3 receptors and TTX resistant sodium channels (Na(V)1.8) on muscle nerve fibers in pain-free humans and patients with chronic myofascial temporomandibular disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Nikolaos Christidis,Isabell Kang,Brian E Cairns,Ujendra Kumar,Xudong Dong,Annika Rosén,Sigvard Kopp,Malin Ernberg

PloS one 8:e76084 PubMed24086692

2013

The voltage-gated sodium channel nav1.8 is expressed in human sperm.

Applications

ICC/IF, Flow Cyt

Species

Human, Human

Antonio Cejudo-Roman,Francisco M Pinto,Nerea Subirán,Cristina G Ravina,Manuel Fernández-Sánchez,Natalia Pérez-Hernández,Ricardo Pérez,Alberto Pacheco,Jon Irazusta,Luz Candenas

Reproductive biology and endocrinology : RB&E 7:71 PubMed19607678

2009

Molecular and functional characterization of voltage-gated sodium channels in human sperm.

Applications

ICC/IF

Species

Human

Francisco M Pinto,Cristina G Ravina,Manuel Fernández-Sánchez,Manuel Gallardo-Castro,Antonio Cejudo-Román,Luz Candenas
View all publications
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代替製品

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