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AB63331

Anti-Nav1.8/SCN10A 抗体

Anti-Nav1.8/SCN10A antibody

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(5 Publications)

Rabbit Polyclonal Nav1.8/SCN10A antibody. Suitable for ICC, WB, IHC-Fr and reacts with Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Rat Scn10a aa 1850 to C-terminus.

別名を表示する

Sns, Scn10a, Sodium channel protein type 10 subunit alpha, Peripheral nerve sodium channel 3, Sensory neuron sodium channel, Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, PN3

1 Images
Immunohistochemistry (Frozen sections) - Anti-Nav1.8/SCN10A antibody (AB63331)
  • IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Nav1.8/SCN10A antibody (AB63331)

Immunohistochemistry was performed on 2 week old rat lumber DRG sections. NaV1.8/SCN10A-like immunoreactivity can be detected only in small diameter (<30 um) neurons.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat

アプリケーション

WB, ICC, IHC-Fr

applications

免疫原

Synthetic Peptide within Rat Scn10a aa 1850 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q62968

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代替製品

Primary Antibodies

AB93616

Anti-Nav1.8/SCN10A antibody [S134]

BOND RX™ Validated|Recombinant

Immunohistochemistry (Frozen sections) - Anti-Nav1.8/SCN10A antibody [S134] (AB93616)

  • 4
  • 2
Primary Antibodies

AB66743

Anti-Nav1.8/SCN10A antibody

Immunocytochemistry - Anti-Nav1.8/SCN10A antibody (AB66743)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB9110

Anti-HA tag antibody - ChIP Grade

Immunoprecipitation - Anti-HA tag antibody - ChIP Grade (AB9110)

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Primary Antibodies

AB65167

Anti-Nav1.7 antibody

  • 4
  • 3
Primary Antibodies

AB245230

Anti-BRN3A antibody [EPR23257-285]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-BRN3A antibody [EPR23257-285] (AB245230)

  • 5
  • 2
Primary Antibodies

AB52623

Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|Lab Essentials|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody [EP1569Y] - Neuronal Marker (AB52623)

  • 5
  • 6
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/4000", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Constituents: PBS, Whole serum
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Nav1.8 also known as SCN10A is a voltage-gated sodium channel. It facilitates the rapid transit of sodium ions across cell membranes essential for the propagation of action potentials in neurons. Nav1.8 has a mass of approximately 220 kDa and it expresses primarily in peripheral sensory neurons including dorsal root ganglia. This channel is activated mainly in response to depolarization enabling the initiation and conduction of electrical signals.
Biological function summary

Nav1.8 contributes significantly to pain transmission especially in nociceptive neurons which detect painful stimuli. It operates as a principal component in generating sustained action potentials required for pain signal propagation. Nav1.8 is not a part of a larger complex but plays a standalone critical role. It shows high expression during inflammatory and neuropathic pain conditions indicating its role in pain pathways.

Pathways

Nav1.8 is involved in both the pain and neuroinflammatory pathways. It influences the activity of other sodium channels such as Nav1.7 another critical mediator of pain sensation. Pain pathways extensively integrate Nav1.8 function especially in the modulation of pain thresholds and states. Neuroinflammatory pathways utilize Nav1.8 to alter neuron excitability under inflammatory conditions which is significant for understanding different pain modalities.

Nav1.8 is associated with chronic pain disorders such as neuropathic pain and inflammatory pain conditions. Variations in Nav1.8 are linked to altered pain sensitivity and are researched as potential therapeutic targets for pain relief. In diseases like diabetic neuropathy Nav1.8 changes correlate with increased neuronal excitability and persistent pain sensation. Its relationship with proteins like Nav1.7 in these contexts highlights its importance in the diagnostic and therapeutic options for pain management.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
See full target information Scn10a
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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Neural development 19:1 PubMed38167468

2024

Loss of G9a does not phenocopy the requirement for Prdm12 in the development of the nociceptive neuron lineage.

Applications

Unspecified application

Species

Unspecified reactive species

Panagiotis Tsimpos,Simon Desiderio,Pauline Cabochette,Philippe Poelvoorde,Sadia Kricha,Luc Vanhamme,Coralie Poulard,Eric J Bellefroid

The FEBS journal 289:3457-3476 PubMed35029322

2022

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.

Applications

Unspecified application

Species

Unspecified reactive species

Tomislav Kokotović,Ewelina M Lenartowicz,Michiel Langeslag,Cosmin I Ciotu,Christopher W Fell,Angelica Scaramuzza,Michael J M Fischer,Michaela Kress,Josef M Penninger,Vanja Nagy

Pain 163:e927-e941 PubMed34961757

2021

Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors.

Applications

Unspecified application

Species

Unspecified reactive species

Aurore Latragna,Alba Sabaté San José,Panagiotis Tsimpos,Simon Vermeiren,Roberta Gualdani,Sampurna Chakrabarti,Gerard Callejo,Simon Desiderio,Orr Shomroni,Maren Sitte,Sadia Kricha,Maëlle Luypaert,Benoit Vanhollebeke,Geoffroy Laumet,Gabriela Salinas,Ewan St John Smith,Laurence Ris,Eric J Bellefroid

Cell reports 26:3522-3536.e5 PubMed30917309

2019

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.

Applications

Unspecified application

Species

Unspecified reactive species

Simon Desiderio,Simon Vermeiren,Claude Van Campenhout,Sadia Kricha,Elisa Malki,Sven Richts,Emily V Fletcher,Thomas Vanwelden,Bela Z Schmidt,Kristine A Henningfeld,Tomas Pieler,C Geoffrey Woods,Vanja Nagy,Catherine Verfaillie,Eric J Bellefroid

Journal of cell science 127:216-29 PubMed24190886

2013

Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Joerg Isensee,Mandy Diskar,Steffen Waldherr,René Buschow,Jan Hasenauer,Anke Prinz,Frank Allgöwer,Friedrich W Herberg,Tim Hucho
View all publications
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