AB65167

Anti-Nav1.7 抗体

Name: Anti-Nav1.7 抗体 (ab65167) | Abcam
Brand: Abcam Limited
SKU: AB65167
Price: 68000 JPY
Availability: InStock
Rating: 4 (3 reviews)

Anti-Nav1.7 antibody

(3 Reviews)

(11 Publications)

Anti-Nav1.7 antibody (ab65167) is a rabbit polyclonal antibody detecting Nav1.7 in IHC-P, IHC-Fr, ICC/IF. Suitable for Human, Mouse.

- Trusted since 2008

別名を表示する

NENA, SCN9A, Sodium channel protein type 9 subunit alpha, Neuroendocrine sodium channel, Peripheral sodium channel 1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, hNE-Na, PN1

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human, Mouse

アプリケーション

IHC-FoFr, IHC-Fr, IHC-P, ICC/IF

applications

免疫原

Synthetic Peptide within Human SCN9A aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q15858

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Reactivity data

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製品の詳細

What is this antibody validated in?
Anti-Nav1.7 antibody (ab65167) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse samples.

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Whole antiserum

バッファー組成

Constituents: Whole serum

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Nav1.7 also known as SCN9A is a voltage-gated sodium channel. This protein has a mass of approximately 260 kDa. It plays a role in the generation and conduction of action potentials in neurons. Nav1.7 is found mainly in peripheral neurons including dorsal root ganglia and sympathetic ganglia. These neurons are part of the sensory pathways responsible for transmitting pain signals.

Biological function summary

Nav1.7 acts as an essential component in neuronal excitability. It is not part of a larger protein complex but operates as an individual unit within the cell membrane. By allowing sodium ions to enter the neuron Nav1.7 contributes to the depolarization phase of action potentials. This function is critical in the propagation of electrical signals in the nervous system specifically in nociceptive neurons that are involved in pain sensation.

Pathways

Nav1.7 is integral to the nociceptive pain pathway. It works with other sodium channels such as Nav1.8 which also play roles in pain sensation. Nav1.7's activity helps to initiate and maintain action potentials facilitating the transmission of pain signals to the central nervous system. Additionally Nav1.7 is linked to neuropathic pain pathways where its function underpins the continuous firing of neurons even in the absence of external stimuli.

Nav1.7 mutations have a significant association with primary erythromelalgia and congenital indifference to pain. Mutations that cause gain-of-function in Nav1.7 can lead to primary erythromelalgia resulting in extreme pain and redness in the body’s extremities. Conversely loss-of-function mutations can cause congenital indifference to pain where individuals experience little to no pain sensation. Nav1.7 works alongside Nav1.8 in these conditions as both are involved in the modulation of pain signals.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed : 15385606, PubMed : 16988069, PubMed : 17145499, PubMed : 17167479, PubMed : 19369487, PubMed : 24311784, PubMed : 25240195, PubMed : 26680203, PubMed : 7720699). Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain (PubMed : 17145499, PubMed : 17167479, PubMed : 19369487, PubMed : 24311784).

See full target information SCN9A

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文献 (11)

Recent publications for all applications. Explore the full list and refine your search

mBio 16:e0187125 PubMed40823836

2025

Validation of human sensory neurons derived from inducible pluripotent stem cells as a model for latent infection and reactivation by herpes simplex virus 1.

Applications

Unspecified application

Species

Unspecified reactive species

Hyung Suk Oh,Shu-Fan Chou,Priya Raja,Jaehoon Shim,Biswajit Das,Jean M Pesola,Nicolás Romero,Jennifer S Lee,Alex Ng,Elizabeth D Buttermore,George Church,Clifford J Woolf,Donald M Coen,David M Knipe

Journal of neurochemistry 169:e70004 PubMed39871624

2025

GABA Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell-Derived Sensory Neurons by Baclofen and α-Conotoxin Vc1.1.

Applications

Unspecified application

Species

Unspecified reactive species

Mitchell St Clair-Glover,Arsalan Yousuf,Dominic Kaul,Mirella Dottori,David J Adams

Cell genomics 3:100250 PubMed36950384

2023

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Greta Pintacuda,Yu-Han H Hsu,Kalliopi Tsafou,Ka Wan Li,Jacqueline M Martín,Jackson Riseman,Julia C Biagini,Joshua K T Ching,Daya Mena,Miguel A Gonzalez-Lozano,Shawn B Egri,Jake Jaffe,August B Smit,Nadine Fornelos,Kevin C Eggan,Kasper Lage

Frontiers in pharmacology 12:759730 PubMed34955831

2021

Inhibition of the Nav1.7 Channel in the Trigeminal Ganglion Relieves Pulpitis Inflammatory Pain.

Applications

Unspecified application

Species

Unspecified reactive species

Minjee Kwon,Il Young Jung,Myeounghoon Cha,Bae Hwan Lee

Frontiers in cellular neuroscience 14:600895 PubMed33362470

2020

Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Amy J Hulme,Jeffrey R McArthur,Simon Maksour,Sara Miellet,Lezanne Ooi,David J Adams,Rocio K Finol-Urdaneta,Mirella Dottori

Bioengineering (Basel, Switzerland) 7: PubMed32429423

2020

Conserved Expression of Nav1.7 and Nav1.8 Contribute to the Spontaneous and Thermally Evoked Excitability in IL-6 and NGF-Sensitized Adult Dorsal Root Ganglion Neurons In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Rahul R Atmaramani,Bryan J Black,June Bryan de la Peña,Zachary T Campbell,Joseph J Pancrazio

Journal of cellular biochemistry 119:9888-9898 PubMed30129228

2018

Inhibition of lncRNA X inactivate-specific transcript ameliorates inflammatory pain by suppressing satellite glial cell activation and inflammation by acting as a sponge of miR-146a to inhibit Na 1.7.

Applications

Unspecified application

Species

Unspecified reactive species

Wenbo Sun,Meina Ma,Hongmei Yu,Hong Yu

Molecular medicine reports 17:1839-1846 PubMed29138838

2017

Effects of SCN9A gene modification on Na+ channel and the expression of nerve growth factor in a rat model of diarrhea‑predominant irritable bowel syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Yong-Yan Cai,Chen Li,Zhi-Xin Yan,Na Ma,Fang-Fang Li

Cephalalgia : an international journal of headache 37:1350-1372 PubMed27852962

2016

Anatomy and immunochemical characterization of the non-arterial peptidergic diffuse dural innervation of the rat and Rhesus monkey: Implications for functional regulation and treatment in migraine.

Applications

Unspecified application

Species

Unspecified reactive species

Frank L Rice,Jennifer Y Xie,Phillip J Albrecht,Emily Acker,Justin Bourgeois,Edita Navratilova,David W Dodick,Frank Porreca

Molecular & cellular proteomics : MCP 11:M111.016428 PubMed22311638

2012

Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression.

Applications

IHC-FoFr

Species

Rat

Kim Henningsen,Johan Palmfeldt,Sofie Christiansen,Isabel Baiges,Steffen Bak,Ole Nørregaard Jensen,Niels Gregersen,Ove Wiborg

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Nav1.7 抗体

Anti-Nav1.7 antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (11)

Abcam product promise