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AB175088

Anti-NAT1 抗体

Anti-NAT1 antibody

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(3 Publications)

Rabbit Polyclonal NAT1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NAT1.

別名を表示する

AAC1, NAT1, Arylamine N-acetyltransferase 1, Arylamide acetylase 1, Monomorphic arylamine N-acetyltransferase, N-acetyltransferase type 1, MNAT, NAT-1

1 Images
Western blot - Anti-NAT1 antibody (AB175088)
  • WB

Supplier Data

Western blot - Anti-NAT1 antibody (AB175088)

All lanes:

Western blot - Anti-NAT1 antibody (ab175088) at 1/500 dilution

Lane 1:

A431 cell extracts

Lane 2:

HeLa cell extracts

Predicted band size: 34 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human NAT1.

P18440

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代替製品

Primary Antibodies

AB109114

Anti-NAT1 antibody [EPR3221(2)]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-NAT1 antibody [EPR3221(2)] (AB109114)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB201966

Anti-CamKII gamma antibody [8G10C1]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CamKII gamma antibody [8G10C1] (AB201966)

  • 1
  • 1
Assay Kits

AB214568

Human IgM ELISA Kit

SimpleStep

ELISA - Human IgM ELISA Kit (AB214568)

  • 0
  • 0
Assay Kits

AB195215

Human IgG ELISA Kit

SimpleStep

Sandwich ELISA - Human IgG ELISA Kit (AB195215)

  • 4
  • 6
Assay Kits

AB151276

Mouse IgG ELISA Kit

Sandwich ELISA - Mouse IgG ELISA Kit (AB151276)

  • 4
  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NAT1 also known as arylamine N-acetyltransferase 1 serves as an important enzyme in acetylation reactions. This enzyme with a molecular mass of approximately 33 kDa catalyzes the transfer of acetyl groups to arylamines and other substrates such as hydrazines. By doing so NAT1 influences xenobiotic metabolism. The enzyme is expressed in various tissues most notably in the liver intestine and lung which aligns with its role in detoxifying and metabolizing drugs and carcinogens.
Biological function summary

NAT1 plays a significant role in detoxifying environmental toxins and carcinogens. The enzyme's activity contributes to the acetylation a phase II metabolic reaction which often converts lipophilic substrates into more hydrophilic products for excretion. NAT1 stands independently and does not form part of a larger complex. It shares functional similarities with other N-acetyltransferases but its substrate specificity can differ which influences its distinct biological role.

Pathways

NAT1 is intricately involved in metabolic and detoxification pathways. It participates in the biotransformation of various drugs and environmental carcinogens making it important for xenobiotic metabolism. NAT1 often interacts with cytochrome P450 enzymes during these processes which also contribute to the initial phase I oxidation reactions. The interplay between NAT1 and these detoxification pathways highlights the enzyme's contribution to reducing potential toxicities.

NAT1 has associations with both cancer and hypersensitivity to certain drugs. Variations in NAT1 activity due to genetic polymorphisms can influence individual susceptibility to cancers particularly bladder cancer linked to arylamine exposure. Additionally its interaction with cytochrome P450 enzymes may also impact drug metabolism potentially leading to adverse drug reactions. Understanding NAT1 and its interactions help assess risks related to these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.
See full target information NAT1
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 43:233 PubMed39160581

2024

Areca nut-induced metabolic reprogramming and M2 differentiation promote OPMD malignant transformation.

Applications

Unspecified application

Species

Unspecified reactive species

Shyng-Shiou F Yuan,Leong-Perng Chan,Hieu D H Nguyen,Chang-Wei Su,Yuk-Kwan Chen,Jeff Yi-Fu Chen,Shigetaka Shimodaira,Stephen Chu-Sung Hu,Steven Lo,Yen-Yun Wang

Apoptosis : an international journal on programmed cell death 30:1-15 PubMed39136818

2024

CD24 flags anastasis in melanoma cells.

Applications

Unspecified application

Species

Unspecified reactive species

Martina H Vasileva,Anette Bennemann,Karolin Zachmann,Michael P Schön,Jorge Frank,Vijay Kumar Ulaganathan

Cell 175:1546-1560.e17 PubMed30500537

2018

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxiang Zheng,Ting-Yu Lin,Gina Lee,Marcia N Paddock,Jessica Momb,Zhe Cheng,Qian Li,Dennis L Fei,Benjamin D Stein,Shivan Ramsamooj,Guoan Zhang,John Blenis,Lewis C Cantley
View all publications
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Abcam product promise

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