AB190264

Anti-Myoferlin 抗体

Name: Anti-Myoferlin 抗体 (ab190264) | Abcam
Brand: Abcam Limited
SKU: AB190264
Price: 75000 JPY
Availability: InStock
Rating: 5 (1 reviews)

Anti-Myoferlin antibody

(1 Review)

(4 Publications)

Rabbit Polyclonal Myoferlin antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human MYOF aa 700 to C-terminus.

別名を表示する

FER1L3, KIAA1207, MYOF, Myoferlin, Fer-1-like protein 3

2 Images

Supplier Data

Immunoprecipitation - Anti-Myoferlin antibody (AB190264)

Immunoprecipitation of Hela whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) labeling Myoferlin with ab190264 at 1 μg/ml by western blot. Myoferlin was immunoprecipitated using a control antibody (1) or ab190264 (2) at 6 μg per reaction. Lane 3 shows IgG control.

All lanes:

Immunoprecipitation - Anti-Myoferlin antibody (ab190264)

Predicted band size: 235 kDa

true

Exposure time: 30s

Supplier Data

Western blot - Anti-Myoferlin antibody (AB190264)

All lanes:

Western blot - Anti-Myoferlin antibody (ab190264) at 0.4 µg/mL

All lanes:

Hela whole cell lysate at 50 µg

Predicted band size: 235 kDa

true

Exposure time: 3min

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, IP

applications

免疫原

Synthetic Peptide within Human MYOF aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NZM1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Myoferlin alternatively known as MYOF is a member of the ferlin family proteins and plays a mechanical role in membrane repair and fusion. It has a molecular mass of approximately 230 kDa. Myoferlin expresses mainly in muscle and endothelial tissues. Its function is critical during muscle development and regeneration as it participates in the fusion of myoblasts into mature myotubes. Also Myoferlin is involved in the repair of damaged sarcolemmal membranes in muscle cells.

Biological function summary

The protein supports membrane dynamics and stabilization. Myoferlin is not part of a large complex but interacts with other proteins at the cellular membrane. It regulates cellular processes such as proliferation differentiation and endocytosis. In muscle cells it assists in the organization and function of the cytoskeleton maintaining proper cellular architecture and signaling.

Pathways

Myoferlin engages in critical roles in pathways related to cell membrane repair and trafficking. It associates with pathways like the myogenesis pathway and integrin signaling. In these pathways it interacts with other proteins such as dysferlin and caveolin-3 which facilitate membrane repair and receptor localization respectively. Myoferlin ensures efficient cellular response to membrane damage maintaining tissue integrity.

Myoferlin is connected to muscular dystrophies and cancer. It correlates with the progression of muscular disorder due to its deficiency in membrane repair mechanisms. Additionally in cancer its expression levels relate to tumor invasion and metastasis involving interactions with proteins like E-cadherin and MMP-9. Investigating Myoferlin's role can aid in understanding its potential as a therapeutic target in these diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).

See full target information MYOF

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39:e70739 PubMed40542649

2025

Mitochondria-Homing Drug Mitochonic Acid 5 Improves Barth Syndrome Myopathy in a Human-Induced Pluripotent Stem Cell Model and Barth Syndrome Drosophila Model.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiyasu Tongu,Tomoko Kasahara,Tetsuro Matsuhashi,Yoshitsugu Oikawa,Ryota Akimoto,Yuhan Luo,Sayaka Sekine,Momoka Suzuki,Hitomi Kashiwagi,Shinichiro Kanno,Yoshikazu Tanaka,Kyohei Sato,Yusuke Okubo,Akihiko Muto,Hidetaka Tokuno,Chitose Suzuki,Chiharu Kawabe,Takamasa Ishikawa,Shun Watanabe,Koichi Kikuchi,Shun Itai,Takeya Sato,Takehiro Suzuki,Kazuhiro Igarashi,Shinji Fukuda,Tomoyoshi Soga,Kei Murayama,Erina Kuranaga,Takafumi Toyohara,Takaaki Abe

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 22:e00500 PubMed39613526

2024

Anti-RGMa neutralizing antibody ameliorates vascular cognitive impairment in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Masaya Yamamoto,Takahide Itokazu,Hiroki Uno,Takakuni Maki,Nao Shibuya,Toshihide Yamashita

Biomaterials 241:119906 PubMed32114218

2020

Membrane fusion FerA domains enhance adeno-associated virus vector transduction.

Applications

Unspecified application

Species

Unspecified reactive species

Xintao Zhang,Bui Anthony,Zheng Chai,Amanda Lee Dobbins,Roger Bryan Sutton,Chengwen Li

HRB open research 1:17 PubMed35528858

2018

Chemical crosslinking analysis of β-dystroglycan in dystrophin-deficient skeletal muscle.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra Murphy,Margit Zweyer,Rustam R Mundegar,Dieter Swandulla,Kay Ohlendieck

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Myoferlin 抗体

Anti-Myoferlin antibody

Immunoprecipitation - Anti-Myoferlin antibody (AB190264)

Western blot - Anti-Myoferlin antibody (AB190264)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Reagents, Controls & Accessories

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

Abcam product promise